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Study · Systematic review · n = 288 · 2022

2 results

The neural effects of oxytocin administration in autism spectrum disorders studied by fMRI: A systematic review.

Fathabadipour S, Mohammadi Z, Roshani F, Goharbakhsh N, Alizadeh H, Palizgar F, Cumming P, Michel TM, Vafaee MS

Journal of psychiatric research4 Aug 2022Cited by 19 (Europe PMC)

PMID35933858 (opens in a new tab)DOI10.1016/j.jpsychires.2022.06.033 (opens in a new tab)PepBankPUB-35933858
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanSystematic reviewEfficacy outcome

    In a systematic review of 12 fMRI studies in individuals with ASD, intranasal oxytocin altered brain activation, with effects that depended on the task.

    In plain wordsIn a review of brain-scan studies of people with autism, nasal oxytocin changed brain activity, and the change depended on the task.

    Peptide
    Oxytocin
    Outcome
    MixedBrain activation on fMRI
    Study

    n = 288

    Comparator
    Placebo (in the included trials)
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    The systematic review of the 12 studies supported the proposition that IN-OXT administration alters brain activation in individuals with ASD. The effects of IN-OXT interacted with the type of the task and the overall results did not indicate restoration of normal brain activation in ASD signature re…
    1 context sentence
    Summary · context
    The search yielded 12 fMRI studies with OXT intervention, including 288 individuals with ASD (age 8-55 years) enrolled in randomized, double-blind, placebo-controlled, parallel designs, within-subject-crossover experimental OXT trials.
  2. 02HumanSystematic reviewEfficacy outcome

    In a systematic review of 12 fMRI studies in individuals with ASD, the overall results did not indicate that intranasal oxytocin restored normal brain activation in ASD signature regions.

    In plain wordsIn a review of brain-scan studies of people with autism, nasal oxytocin did not bring brain activity back to typical levels.

    Peptide
    Oxytocin
    Outcome
    No significant changeRestoration of normal brain activation in ASD signature regions
    Study

    n: not reported in source

    Comparator
    Placebo (in the included trials)
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    the overall results did not indicate restoration of normal brain activation in ASD signature regions albeit the lack of statistical evidence.
    1 context sentence
    Summary · context
    The search yielded 12 fMRI studies with OXT intervention, including 288 individuals with ASD (age 8-55 years) enrolled in randomized, double-blind, placebo-controlled, parallel designs, within-subject-crossover experimental OXT trials.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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