An injectable thermosensitive hydrogel with a self-assembled peptide coupled with an antimicrobial peptide for enhanced wound healing.

Feng T, Wu H, Ma W, Wang Z, Wang C, Wang Y, Wang S, Zhang M, Hao L

Journal of materials chemistry. B17 Aug 2022Cited by 34 (Europe PMC)

PMID35924330DOI10.1039/d2tb00644hPepBankPUB-35924330

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MGF / PEG-MGF.

01AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Efficacy outcome
In rats with full-thickness skin wounds, the PNI/RA-Amps/E hydrogel accelerated epithelialization compared with a commercial dressing.
In plain wordsIn rats, the hydrogel with MGF E peptide and another peptide sped up skin closure more than a commercial dressing.
Peptide
MGF / PEG-MGF
Outcome
IncreaseEpithelialization in rat full-thickness skin wounds
Study
ratn: not reported in source
Rat full-thickness skin wound
Comparator
Commercial dressing
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
Rat full-thickness skin experiments revealed that the PNI/RA-Amps/E hydrogel accelerates wound healing significantly by accelerating epithelialization, the generation of new blood vessels and promoting the generation of collagen fiber compared with commercial dressing.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein, RA-Amps was fabricated by coupling a self-assembled peptide RADA16 with an antibacterial peptide (Amps) and incorporated into a PNIPAM hydrogel containing an MGF E peptide to develop a multi-functional composite hydrogel with thermo-response properties, good biocompatibility, good mechanical…
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-3592433002
02AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Efficacy outcome
In rats with full-thickness skin wounds, the PNI/RA-Amps/E hydrogel accelerated the generation of new blood vessels compared with a commercial dressing.
In plain wordsIn rats, the hydrogel with MGF E peptide and another peptide promoted new blood vessel growth more than a commercial dressing.
Peptide
MGF / PEG-MGF
Outcome
IncreaseNew blood vessel generation in rat skin wounds
Study
ratn: not reported in source
Rat full-thickness skin wound
Comparator
Commercial dressing
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
Rat full-thickness skin experiments revealed that the PNI/RA-Amps/E hydrogel accelerates wound healing significantly by accelerating epithelialization, the generation of new blood vessels and promoting the generation of collagen fiber compared with commercial dressing.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein, RA-Amps was fabricated by coupling a self-assembled peptide RADA16 with an antibacterial peptide (Amps) and incorporated into a PNIPAM hydrogel containing an MGF E peptide to develop a multi-functional composite hydrogel with thermo-response properties, good biocompatibility, good mechanical…
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-3592433003
03AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Efficacy outcome
In rats with full-thickness skin wounds, the PNI/RA-Amps/E hydrogel promoted collagen fiber generation compared with a commercial dressing.
In plain wordsIn rats, the hydrogel with MGF E peptide and another peptide promoted more collagen fiber than a commercial dressing.
Peptide
MGF / PEG-MGF
Outcome
IncreaseCollagen fiber generation in rat skin wounds
Study
ratn: not reported in source
Rat full-thickness skin wound
Comparator
Commercial dressing
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
Rat full-thickness skin experiments revealed that the PNI/RA-Amps/E hydrogel accelerates wound healing significantly by accelerating epithelialization, the generation of new blood vessels and promoting the generation of collagen fiber compared with commercial dressing.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein, RA-Amps was fabricated by coupling a self-assembled peptide RADA16 with an antibacterial peptide (Amps) and incorporated into a PNIPAM hydrogel containing an MGF E peptide to develop a multi-functional composite hydrogel with thermo-response properties, good biocompatibility, good mechanical…
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-3592433004
04AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Efficacy outcome
In rats with full-thickness skin wounds, the PNI/RA-Amps/E hydrogel accelerated wound healing significantly compared with a commercial dressing.
In plain wordsIn rats, the hydrogel with MGF E peptide and another peptide healed skin wounds faster than a commercial dressing.
Peptide
MGF / PEG-MGF
Outcome
IncreaseOverall wound healing in rat skin wounds
Study
ratn: not reported in source
Rat full-thickness skin wound
Comparator
Commercial dressing
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
Rat full-thickness skin experiments revealed that the PNI/RA-Amps/E hydrogel accelerates wound healing significantly by accelerating epithelialization, the generation of new blood vessels and promoting the generation of collagen fiber compared with commercial dressing.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein, RA-Amps was fabricated by coupling a self-assembled peptide RADA16 with an antibacterial peptide (Amps) and incorporated into a PNIPAM hydrogel containing an MGF E peptide to develop a multi-functional composite hydrogel with thermo-response properties, good biocompatibility, good mechanical…
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-3592433005
05LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Efficacy outcome
A hydrogel that loaded MGF E peptide together with RA-Amps released the peptide continuously and promoted fibroblast proliferation.
In plain wordsIn cells, a hydrogel with MGF E peptide and another peptide released it steadily and promoted fibroblast growth.
Peptide
MGF / PEG-MGF
Outcome
IncreaseFibroblast proliferation with MGF E peptide-loaded hydrogel
Study
n: not reported in source
Fibroblasts exposed to PNIPAM hydrogel with RA-Amps and MGF E peptide
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
MGF E peptide was loaded into a hydrogel and released continuously to promote fibroblast proliferation.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein, RA-Amps was fabricated by coupling a self-assembled peptide RADA16 with an antibacterial peptide (Amps) and incorporated into a PNIPAM hydrogel containing an MGF E peptide to develop a multi-functional composite hydrogel with thermo-response properties, good biocompatibility, good mechanical…
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-3592433001

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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