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Study · Measured the body's own peptide · 2022

2 results

Autism Spectrum Disorder Model Mice Induced by Prenatal Exposure to Valproic Acid Exhibit Enhanced Empathy-Like Behavior via Oxytocinergic Signaling.

Takayama K, Tobori S, Andoh C, Kakae M, Hagiwara M, Nagayasu K, Shirakawa H, Ago Y, Kaneko S

Biological & pharmaceutical bulletin1 Jan 2022Cited by 10 (Europe PMC)

PMID35908894 (opens in a new tab)DOI10.1248/bpb.b22-00200 (opens in a new tab)PepBankPUB-35908894
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In valproic acid-treated mice, the number of c-Fos positive oxytocinergic neurons in the paraventricular nucleus was higher after observational fear learning.

    In plain wordsIn mice, the body's own oxytocin-producing brain cells were more active after the empathy test in the autism model.

    Peptide
    Oxytocin
    Outcome
    Increasec-Fos positive oxytocinergic neurons in the PVN after observational fear learning
    Study

    mousen: not reported in source

    Mice prenatally exposed to valproic acid (ASD model)
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Immunohistochemical analysis revealed that the number of c-Fos positive oxytocinergic neurons in the paraventricular nucleus of the hypothalamus (PVN) was significantly higher in VPA-treated mice after observational fear learning.
    1 context sentence
    Summary · context
    In this study, we assessed empathy-like behaviors in valproic acid (VPA)-treated mice-a mouse model of ASD with observational fear learning.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In valproic acid-treated mice, pretreatment with the oxytocin receptor antagonist L-368899 repressed empathy-like behavior; the antagonist, not oxytocin, was the tested drug.

    In plain wordsIn mice, a drug that blocks the oxytocin receptor reduced empathy-like behavior in the autism model.

    Peptide
    Oxytocin
    Outcome
    DecreaseEmpathy-like behavior after oxytocin receptor antagonist L-368899
    Study

    mousen: not reported in source

    Mice prenatally exposed to valproic acid (ASD model)
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Finally, we found that pretreatment with L-368899, an antagonist of the oxytocin receptor, repressed the empathetic behavior in VPA-treated mice.
    1 context sentence
    Summary · context
    In this study, we assessed empathy-like behaviors in valproic acid (VPA)-treated mice-a mouse model of ASD with observational fear learning.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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