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Study · PubMed tag: none · 2022

Retracted

Effect of Vitamin D Combined with Recombinant Human Growth Hormone in Children with Growth Hormone Deficiency.

Wang P, Jin X, Zhang Y, Zhang J, Li Y, Yang S, Li D

Disease markers19 Jul 2022Cited by 1 (Europe PMC)

PMID35903295 (opens in a new tab)PMCIDPMC9325485 (opens in a new tab)DOI10.1155/2022/7461958 (opens in a new tab)PepBankPUB-35903295
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Summary

ObjectiveGrowth hormone deficiency (GHD) refers to the complete or partial lack of pituitary growth hormone synthesis and secretion. This study is aimed at investigating the efficacy of vitamin D and recombinant human growth hormone (rhGH) in children with GHD.MethodsA total of 100 children with GHD at our hospital were included between 1st January 2018 and 31st October 2020. The patients were divided into a study group (n = 70, received vitamin D combined with rhGH) and a control group (n = 30, received rhGH). The growth and development (bone age, growth rate, and height), bone metabolism (bone alkaline phosphatase (BAP), β-collagen degradation product (β-CTX), osteocalcin (OC), and amino-terminal propeptide type I procollagen (PINP)), insulin-like growth factor 1 (IGF-1), ghrelin, and adverse reactions in the two groups were measured before and 12 months after treatment.ResultsThere were no significant differences in the bone age, growth rate, and height between the two groups before treatment. After 12 months of treatment, the bone age, growth rate, and height of the study group were significantly higher than those of the control group. After 12 months of treatment, the levels of serum BAP, PINP, and OC in the study group were significantly higher than those in the control group, while the levels of β-CTX in the study group were significantly lower than those in the control group. The serum IGF-1 level in the study group was significantly higher than that in the control group, while the ghrelin level in the study group was lower. There was no significant difference in the incidence of adverse reactions between the two groups.ConclusionCombined rhGH and vitamin D treatment can promote growth and development, improve bone metabolism, and regulate IGF-1 and ghrelin levels.
CC BYText from Europe PMC. No result points at this text yet.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 16:37 UTC

    Status changed: status, notices · status retracted · status notice from Retraction Watch (Crossref)

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · status retracted · source update from Europe PMC

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