In mice, [D-Lys3]-GHRP‑6 completely blocked the L-ornithine-induced increase in GH release.
In plain wordsIn mice, [D-Lys3]-GHRP‑6 completely blocked the growth hormone increase compared with L-ornithine alone.
- Peptide
- GHRP-6
- Outcome
- DecreaseL-ornithine-induced GH release
- Study
mousen: not reported in source
- Comparator
- L-ornithine without antagonist
- Outcome group
- Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
The l-ornithine-induced increase in GH release was completely blocked by [D-Lys3]-GHRP-6, a ghrelin receptor antagonist, but not by cyclosomatostatin or JV-1-38, antagonists of somatostatin and GH-releasing hormone, respectively.
1 context sentence(design, population, supporting numbers)
Here, we demonstrated that increases in plasma GH levels after oral administration of l-ornithine were first observed 150 min after administration, and the elevated levels were sustained for more than 90 min in mice.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.