Matrixyl Patch vs Matrixyl Cream: A Comparative In Vivo Investigation of Matrixyl (MTI) Effect on Wound Healing.

Kachooeian M, Mousivand Z, Sharifikolouei E, Shirangi M, Firoozpour L, Raoufi M, Sharifzadeh M, Sharifzadeh M

ACS omega11 Jul 2022Cited by 4 (Europe PMC)

PMID35874243PMCIDPMC9301720DOI10.1021/acsomega.2c02592PepBankPUB-35874243

Read at source PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study7

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In animals, Matrixyl cream had a greater effect on wound healing than Comfeel.
In plain wordsIn animals, Matrixyl cream improved wound healing more than Comfeel.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreaseCream wound healing versus Comfeel
Study
n: not reported in source
Comparator
Comfeel
Outcome group
Wound healing · Skin and wound
Studied dose
1 mg · 21 daysAs given in this study.
Source sentences
Summary
In addition, C-MTI-1 and P-MTI-1 had a larger impact on wound healing compared to that in the positive control group (Comfeel, P < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, animals were randomly divided into seven groups and studied for 21 days: patches containing two different concentrations of MTI (P-MTI-0.1 mg and P-MTI-1 mg), a cream containing MTI (C-MTI-1 mg), a patch (P-MTI-0), a cream with no MTI (C-MTI-0), a positive control (Comfeel), and a neg…
Report a problemFND-3587424302
02AnimalAnimal study (in vivo)Efficacy outcome
In animals, the Matrixyl patch had a greater effect on wound healing than Comfeel.
In plain wordsIn animals, the Matrixyl patch improved wound healing more than Comfeel.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreasePatch wound healing versus Comfeel
Study
n: not reported in source
Comparator
Comfeel
Outcome group
Wound healing · Skin and wound
Studied dose
1 mg · 21 daysAs given in this study.
Source sentences
Summary
In addition, C-MTI-1 and P-MTI-1 had a larger impact on wound healing compared to that in the positive control group (Comfeel, P < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, animals were randomly divided into seven groups and studied for 21 days: patches containing two different concentrations of MTI (P-MTI-0.1 mg and P-MTI-1 mg), a cream containing MTI (C-MTI-1 mg), a patch (P-MTI-0), a cream with no MTI (C-MTI-0), a positive control (Comfeel), and a neg…
Report a problemFND-3587424303
03AnimalAnimal study (in vivo)Efficacy outcome
In animals, skin appendage rejuvenation was visible after Matrixyl cream treatment.
In plain wordsIn animals, skin appendage renewal was visible after Matrixyl cream treatment.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreaseSkin appendage rejuvenation with cream
Study
n: not reported in source
Outcome group
Wound healing · Skin and wound
Studied dose
Dose not stated · 21 daysAs given in this study.
Source sentences
Summary
In hematoxylin and eosin (H&E) staining analysis, the rejuvenation of skin appendage was visible in both groups of cream and patches with MTI.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, animals were randomly divided into seven groups and studied for 21 days: patches containing two different concentrations of MTI (P-MTI-0.1 mg and P-MTI-1 mg), a cream containing MTI (C-MTI-1 mg), a patch (P-MTI-0), a cream with no MTI (C-MTI-0), a positive control (Comfeel), and a neg…
Report a problemFND-3587424304
04AnimalAnimal study (in vivo)Efficacy outcome
In animals, skin appendage rejuvenation was visible after Matrixyl patch treatment.
In plain wordsIn animals, skin appendage renewal was visible after Matrixyl patch treatment.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreaseSkin appendage rejuvenation with patches
Study
n: not reported in source
Outcome group
Wound healing · Skin and wound
Studied dose
Dose not stated · 21 daysAs given in this study.
Source sentences
Summary
In hematoxylin and eosin (H&E) staining analysis, the rejuvenation of skin appendage was visible in both groups of cream and patches with MTI.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, animals were randomly divided into seven groups and studied for 21 days: patches containing two different concentrations of MTI (P-MTI-0.1 mg and P-MTI-1 mg), a cream containing MTI (C-MTI-1 mg), a patch (P-MTI-0), a cream with no MTI (C-MTI-0), a positive control (Comfeel), and a neg…
Report a problemFND-3587424305
05AnimalAnimal study (in vivo)Efficacy outcome
In animals, Matrixyl patches showed greater re-epithelialization than Matrixyl cream.
In plain wordsIn animals, Matrixyl patches restored skin coverage more than Matrixyl cream.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreasePatch re-epithelialization versus cream
Study
n: not reported in source
Comparator
Matrixyl cream
Outcome group
Wound healing · Skin and wound
Studied dose
Dose not stated · 21 daysAs given in this study.
Source sentences
Summary
According to the obtained results, the re-epithelialization had a higher range for the patch with MTI in comparison with cream containing MTI and positive control.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, animals were randomly divided into seven groups and studied for 21 days: patches containing two different concentrations of MTI (P-MTI-0.1 mg and P-MTI-1 mg), a cream containing MTI (C-MTI-1 mg), a patch (P-MTI-0), a cream with no MTI (C-MTI-0), a positive control (Comfeel), and a neg…
Report a problemFND-3587424306
06AnimalAnimal study (in vivo)Efficacy outcome
In animals, Matrixyl patches showed greater re-epithelialization than the positive control.
In plain wordsIn animals, Matrixyl patches restored skin coverage more than the positive control.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreasePatch re-epithelialization versus positive control
Study
n: not reported in source
Comparator
Positive control (Comfeel)
Outcome group
Wound healing · Skin and wound
Studied dose
Dose not stated · 21 daysAs given in this study.
Source sentences
Summary
According to the obtained results, the re-epithelialization had a higher range for the patch with MTI in comparison with cream containing MTI and positive control.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, animals were randomly divided into seven groups and studied for 21 days: patches containing two different concentrations of MTI (P-MTI-0.1 mg and P-MTI-1 mg), a cream containing MTI (C-MTI-1 mg), a patch (P-MTI-0), a cream with no MTI (C-MTI-0), a positive control (Comfeel), and a neg…
Report a problemFND-3587424307

Studies that did not test the peptide alone1

In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Matrixyl (palmitoyl pentapeptide-4).

07AnimalNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneAnimal study (in vivo)Efficacy outcome
In animals, pooled treatment groups improved wound healing from 63.5 up to 81.81% compared with the negative control.
In plain wordsIn animals, pooled treatment groups improved wound healing compared with the negative control.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreasePooled treatment wound healing
Study
n: not reported in source
Comparator
Negative control (sham)
Outcome group
Wound healing · Skin and wound
Measurements
Wound healing improvement
63.5 to 81.81%
treatment groups versus negative control
Source sentences
Summary
The macroscopic results showed that wound healing was improved from 63.5 up to 81.81% in treatment groups compared to that in the negative control group (P P < 0.001).
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, animals were randomly divided into seven groups and studied for 21 days: patches containing two different concentrations of MTI (P-MTI-0.1 mg and P-MTI-1 mg), a cream containing MTI (C-MTI-1 mg), a patch (P-MTI-0), a cream with no MTI (C-MTI-0), a positive control (Comfeel), and a neg…
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Report a problemFND-3587424301

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.