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Study · Not a test of the peptide alone · 2022

4 results

Construction of Plasmid DNA Expressing Two Isoforms of Insulin-Like Growth Factor-1 and Its Effects on Skeletal Muscle Injury Models.

Lee J, Ko KR, Lee N, Kim S, Yu SS, Kim S, Lee J

Human gene therapy1 Dec 2022Cited by 3 (Europe PMC)

PMID35838121 (opens in a new tab)PMCIDPMC9808797 (opens in a new tab)DOI10.1089/hum.2022.103 (opens in a new tab)PepBankPUB-35838121
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MGF / PEG-MGF.

  1. 01AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Mechanism

    In an animal study, intramuscular injection of IGF-1-X10 plasmid DNA induced expression of IGF-1 Ea and IGF-1 Ec and produced functional IGF-1 protein.

    In plain wordsIn animals, injecting the plasmid into muscle made both IGF-1 forms and working IGF-1 protein.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseIGF-1 Ea and Ec expression after intramuscular plasmid injection
    Study

    n: not reported in source

    Intramuscular injection of IGF-1-X10 plasmid DNA
    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Source sentences

    Summary
    In an animal study, intramuscular injection of plasmid DNA comprising IGF-1-X10 induced the expression of IGF-1 Ea and IGF-1 Ec, leading to the production of functional IGF-1 protein.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  2. 02AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Efficacy outcome

    In a cardiotoxin muscle injury model and an age-related muscle atrophy model, IGF-1-X10 plasmid DNA increased muscle mass.

    In plain wordsIn animal models of muscle injury and ageing, the IGF-1 plasmid increased muscle mass.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMuscle mass in cardiotoxin injury and age-related atrophy models
    Study

    n: not reported in source

    Cardiotoxin muscle injury model and age-related muscle atrophy model
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    We found that IGF-1-X10 increased the muscle mass and controlled several key factors involved in the muscle atrophy program in both models.
    1 context sentence
    Summary · context
    Finally, the efficacy of this plasmid DNA was tested in a cardiotoxin (CTX)-mediated muscle injury model and age-related muscle atrophy model.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  3. 03AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Mechanism

    In both muscle injury and age-related atrophy models, IGF-1-X10 plasmid DNA controlled several key factors of the muscle atrophy program; the abstract gives no direction.

    In plain wordsIn animal muscle models, the IGF-1 plasmid affected several factors that drive muscle wasting. The abstract does not give the direction.

    Peptide
    MGF / PEG-MGF
    Outcome
    Direction not reportedKey factors of the muscle atrophy program
    Study

    n: not reported in source

    Cardiotoxin muscle injury model and age-related muscle atrophy model
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    controlled several key factors involved in the muscle atrophy program in both models.
    1 context sentence
    Summary · context
    Finally, the efficacy of this plasmid DNA was tested in a cardiotoxin (CTX)-mediated muscle injury model and age-related muscle atrophy model.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  4. 04LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Mechanism

    In human cells, the IGF-1-X10 sequence expressed both IGF-1 Ea and IGF-1 Ec at transcript and protein levels.

    In plain wordsIn human cells, a new gene construct made both IGF-1 forms at the RNA and protein level.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseIGF-1 Ea and Ec expression in transfected human cells
    Study

    humann: not reported in source

    Human cells transfected with IGF-1-X10
    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Source sentences

    Summary
    When transfected into human cells, the expression of both isoforms was observed at the transcript and protein levels.
    1 context sentence
    Summary · context
    In this study, we designed a novel nucleotide sequence, IGF-1-X10, consisting of IGF-1 exons and introns to simultaneously express both IGF-1 Ea and IGF-1 Ec.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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