The safety and efficacy of add-on use of oxytocin in uterine leiomyoma patients undergoing high-intensity focused ultrasound and ultrasound-guided intratumoral ethanol injection: a randomized controlled trial.

Zhang R, Zhang Y, Yang Z, Chen J, Wang Q, Ma J, Zhang B, Zhang H

Annals of palliative medicine1 Jun 2022Cited by 4 (Europe PMC)

PMID35817738DOI10.21037/apm-22-602PepBankPUB-35817738

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

01HumanRandomized controlled trialEfficacy outcome
In women with uterine leiomyoma treated with HIFU and ethanol injection, add-on oxytocin did not change the volume ablation rate compared with treatment without oxytocin.
In plain wordsIn women with uterine fibroids, adding oxytocin to the treatment did not change how much of the fibroid was destroyed.
Peptide
Oxytocin
Outcome
No significant changeLeiomyoma volume ablation rate
Study
n = 60
Comparator
HIFU plus ethanol injection without oxytocin
Outcome group
Uterine fibroid outcomes · Reproductive and sexual health
Studied dose
Dose not stated · injectionAs given in this study (human).
Source sentences
Summary
There were no statistically significant differences between the 2 groups in terms of leiomyoma volume ablation rate (94.48%±2.07% vs. 94.91%±2.53%, P=0.36), crumb gray time (150.70±57.51 vs. 165.77±77.13 s, P=0.37), total treatment energy (556,835.0±202,583 vs. 512,610.0±158,004 J, P=0.19), and tota…
1 context sentence(design, population, supporting numbers)
Summary · context
A total of 60 patients with uterine leiomyomas were included and randomly divided into study group and control group. The patients in the control group were treated with HIFU and ultrasound-guided percutaneous anhydrous ethanol injection, while the study group received oxytocin injection in addition…
Report a problemFND-3581773801
02HumanRandomized controlled trialEfficacy outcome
In women with uterine leiomyoma treated with HIFU and ethanol injection, add-on oxytocin did not change crumb gray time compared with treatment without oxytocin.
In plain wordsIn women with uterine fibroids, adding oxytocin did not change the crumb gray time of the procedure compared with treatment without it.
Peptide
Oxytocin
Outcome
No significant changeCrumb gray time
Study
n = 60
Comparator
HIFU plus ethanol injection without oxytocin
Outcome group
Uterine fibroid outcomes · Reproductive and sexual health
Studied dose
Dose not stated · injectionAs given in this study (human).
Source sentences
Summary
There were no statistically significant differences between the 2 groups in terms of leiomyoma volume ablation rate (94.48%±2.07% vs. 94.91%±2.53%, P=0.36), crumb gray time (150.70±57.51 vs. 165.77±77.13 s, P=0.37), total treatment energy (556,835.0±202,583 vs. 512,610.0±158,004 J, P=0.19), and tota…
1 context sentence(design, population, supporting numbers)
Summary · context
A total of 60 patients with uterine leiomyomas were included and randomly divided into study group and control group. The patients in the control group were treated with HIFU and ultrasound-guided percutaneous anhydrous ethanol injection, while the study group received oxytocin injection in addition…
Report a problemFND-3581773802
03HumanRandomized controlled trialEfficacy outcome
In women with uterine leiomyoma treated with HIFU and ethanol injection, add-on oxytocin did not change total treatment energy compared with treatment without oxytocin.
In plain wordsIn women with uterine fibroids, adding oxytocin did not change the total energy used in treatment compared with treatment without it.
Peptide
Oxytocin
Outcome
No significant changeTotal treatment energy
Study
n = 60
Comparator
HIFU plus ethanol injection without oxytocin
Outcome group
Uterine fibroid outcomes · Reproductive and sexual health
Studied dose
Dose not stated · injectionAs given in this study (human).
Source sentences
Summary
There were no statistically significant differences between the 2 groups in terms of leiomyoma volume ablation rate (94.48%±2.07% vs. 94.91%±2.53%, P=0.36), crumb gray time (150.70±57.51 vs. 165.77±77.13 s, P=0.37), total treatment energy (556,835.0±202,583 vs. 512,610.0±158,004 J, P=0.19), and tota…
1 context sentence(design, population, supporting numbers)
Summary · context
A total of 60 patients with uterine leiomyomas were included and randomly divided into study group and control group. The patients in the control group were treated with HIFU and ultrasound-guided percutaneous anhydrous ethanol injection, while the study group received oxytocin injection in addition…
Report a problemFND-3581773803
04HumanRandomized controlled trialEfficacy outcome
In women with uterine leiomyoma treated with HIFU and ethanol injection, add-on oxytocin did not change total treatment time compared with treatment without oxytocin.
In plain wordsIn women with uterine fibroids, adding oxytocin did not change how long the treatment took compared with treatment without it.
Peptide
Oxytocin
Outcome
No significant changeTotal treatment time
Study
n = 60
Comparator
HIFU plus ethanol injection without oxytocin
Outcome group
Uterine fibroid outcomes · Reproductive and sexual health
Studied dose
Dose not stated · injectionAs given in this study (human).
Source sentences
Summary
There were no statistically significant differences between the 2 groups in terms of leiomyoma volume ablation rate (94.48%±2.07% vs. 94.91%±2.53%, P=0.36), crumb gray time (150.70±57.51 vs. 165.77±77.13 s, P=0.37), total treatment energy (556,835.0±202,583 vs. 512,610.0±158,004 J, P=0.19), and tota…
1 context sentence(design, population, supporting numbers)
Summary · context
A total of 60 patients with uterine leiomyomas were included and randomly divided into study group and control group. The patients in the control group were treated with HIFU and ultrasound-guided percutaneous anhydrous ethanol injection, while the study group received oxytocin injection in addition…
Report a problemFND-3581773804
05HumanRandomized controlled trialSafety outcome
In women with uterine leiomyoma treated with HIFU and ethanol injection, the pain score was higher with add-on oxytocin than with treatment without oxytocin.
In plain wordsIn women with uterine fibroids, pain scores were higher when oxytocin was added than with the same treatment without oxytocin.
Peptide
Oxytocin
Outcome
IncreasePain score
Study
n = 60
Comparator
HIFU plus ethanol injection without oxytocin
Outcome group
Pain · Reproductive and sexual health
Studied dose
Dose not stated · injectionAs given in this study (human).
Source sentences
Summary
The pain score of the oxytocin group was significantly greater than that in the control group (4.53±1.55 vs. 3.60±1.19, P=0.008).
1 context sentence(design, population, supporting numbers)
Summary · context
A total of 60 patients with uterine leiomyomas were included and randomly divided into study group and control group. The patients in the control group were treated with HIFU and ultrasound-guided percutaneous anhydrous ethanol injection, while the study group received oxytocin injection in addition…
Report a problemFND-3581773805
06HumanRandomized controlled trialEfficacy outcome
In women with uterine leiomyoma treated with HIFU and ethanol injection, residual necrotic leiomyoma volume at 3 months and 1 year did not differ between add-on oxytocin and treatment without oxytocin.
In plain wordsIn women with uterine fibroids, the leftover fibroid volume at 3 months and 1 year was no different with added oxytocin.
Peptide
Oxytocin
Outcome
No significant changeResidual necrotic leiomyoma volume at 3 months and 1 year
Study
n = 60
Comparator
HIFU plus ethanol injection without oxytocin
Outcome group
Uterine fibroid outcomes · Reproductive and sexual health
Studied dose
Dose not stated · injectionAs given in this study (human).
Source sentences
Summary
At 3 months and 1-year post-therapy, no statistically significant differences were observed in the residual necrotic leiomyoma volume between the 2 groups.
1 context sentence(design, population, supporting numbers)
Summary · context
A total of 60 patients with uterine leiomyomas were included and randomly divided into study group and control group. The patients in the control group were treated with HIFU and ultrasound-guided percutaneous anhydrous ethanol injection, while the study group received oxytocin injection in addition…
Report a problemFND-3581773806

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 00:50 UTC
Study results updated
Version 1
9 Oct 2026, 02:48 UTC
First added · source update from Europe PMC

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