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Study · Randomized controlled trial · n = 200 · 2022

4 results

A randomized controlled trial examining the effects of intranasal oxytocin on alcohol craving and intimate partner aggression among couples.

Flanagan JC, Nietert PJ, Sippel L, Jarnecke AM, Kirby C, Hogan JN, Massa AA, Brower J, Back SE, Parrott D

Journal of psychiatric research9 Jun 2022Cited by 17 (Europe PMC)

PMID35709548 (opens in a new tab)PMCIDPMC9308670 (opens in a new tab)DOI10.1016/j.jpsychires.2022.06.011 (opens in a new tab)PepBankPUB-35709548
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In couples with alcohol use disorder and intimate partner aggression, a single intranasal oxytocin dose did not differ from placebo on any primary outcome.

    In plain wordsIn couples with alcohol problems and partner aggression, one dose of oxytocin spray did not differ from placebo on any main outcome.

    Peptide
    Oxytocin
    Outcome
    No significant changeAll primary outcomes
    Study

    n = 200

    Comparator
    Placebo
    Analysis
    Primary
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    40 international units · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    There were no statistically significant differences between the oxytocin and placebo conditions for any of the primary outcomes.
    1 context sentence
    Summary · context
    The goal of this double-blind, randomized, and placebo-controlled trial was to examine the effects of a single dose of intranasal oxytocin (40 international units) on cue-induced alcohol craving, subjective aggression, laboratory task-based IPA, and cortisol reactivity in a sample of 100 couples (N…
  2. 02HumanRandomized controlled trialEfficacy outcome

    In couples with alcohol use disorder and intimate partner aggression, a single intranasal oxytocin dose did not reduce alcohol craving compared with placebo.

    In plain wordsIn couples with alcohol problems and partner aggression, one dose of oxytocin spray did not reduce alcohol craving compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeCue-induced alcohol craving
    Study

    n = 200

    Comparator
    Placebo
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    40 international units · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    Findings suggest that a single dose of intranasal oxytocin was not efficacious in mitigating alcohol craving or aggression in this sample.
    2 context sentences
    Summary · context
    There were no statistically significant differences between the oxytocin and placebo conditions for any of the primary outcomes.
    Summary · context
    The goal of this double-blind, randomized, and placebo-controlled trial was to examine the effects of a single dose of intranasal oxytocin (40 international units) on cue-induced alcohol craving, subjective aggression, laboratory task-based IPA, and cortisol reactivity in a sample of 100 couples (N…
  3. 03HumanRandomized controlled trialEfficacy outcome

    In couples with alcohol use disorder and intimate partner aggression, a single intranasal oxytocin dose did not reduce aggression compared with placebo.

    In plain wordsIn couples with alcohol problems and partner aggression, one dose of oxytocin spray did not reduce aggression compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeAggression
    Study

    n = 200

    Comparator
    Placebo
    Outcome group
    Locomotor and behavioral activity · Mental health and mood
    Studied dose
    40 international units · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    Findings suggest that a single dose of intranasal oxytocin was not efficacious in mitigating alcohol craving or aggression in this sample.
    2 context sentences
    Summary · context
    There were no statistically significant differences between the oxytocin and placebo conditions for any of the primary outcomes.
    Summary · context
    The goal of this double-blind, randomized, and placebo-controlled trial was to examine the effects of a single dose of intranasal oxytocin (40 international units) on cue-induced alcohol craving, subjective aggression, laboratory task-based IPA, and cortisol reactivity in a sample of 100 couples (N…
  4. 04HumanRandomized controlled trialSafety outcome

    In couples with alcohol use disorder and intimate partner aggression, a single intranasal oxytocin dose was not aggressogenic.

    In plain wordsIn couples with alcohol problems and partner aggression, one dose of oxytocin spray did not increase aggression.

    Peptide
    Oxytocin
    Outcome
    No significant changeAggressogenic effect of oxytocin
    Study

    n = 200

    Comparator
    Placebo
    Outcome group
    Locomotor and behavioral activity · Mental health and mood
    Studied dose
    40 international units · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    oxytocin was not aggressogenic in this high-risk sample.
    1 context sentence
    Summary · context
    The goal of this double-blind, randomized, and placebo-controlled trial was to examine the effects of a single dose of intranasal oxytocin (40 international units) on cue-induced alcohol craving, subjective aggression, laboratory task-based IPA, and cortisol reactivity in a sample of 100 couples (N…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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