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Study · Randomized controlled trial · n = 61 · 2022

4 results

Intranasal oxytocin attenuates the effects of monetary feedback on procedural learning.

Doppler CEJ, Meyer L, Seger A, Karges W, Weiss PH, Fink GR

Psychoneuroendocrinology3 Jun 2022Cited by 1 (Europe PMC)

PMID35689985 (opens in a new tab)DOI10.1016/j.psyneuen.2022.105823 (opens in a new tab)PepBankPUB-35689985
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy men, intranasal oxytocin did not change general reaction times compared with placebo.

    In plain wordsIn healthy men, oxytocin spray did not change general reaction times compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeGeneral reaction times
    Study

    n = 61

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Groups did not differ regarding general reaction times or measures of procedural learning.
    2 context sentences
    Summary · context
    In a randomized, double-blind, placebo-controlled trial, we investigated whether oxytocin modulates the differential effects of monetary and social feedback on procedural learning.
    Summary · context
    Sixty-one healthy male participants were randomized to receive a placebo or oxytocin intranasally.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy men, intranasal oxytocin did not change measures of procedural learning compared with placebo.

    In plain wordsIn healthy men, oxytocin spray did not change procedural learning compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeProcedural learning
    Study

    n = 61

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Groups did not differ regarding general reaction times or measures of procedural learning.
    2 context sentences
    Summary · context
    In a randomized, double-blind, placebo-controlled trial, we investigated whether oxytocin modulates the differential effects of monetary and social feedback on procedural learning.
    Summary · context
    Sixty-one healthy male participants were randomized to receive a placebo or oxytocin intranasally.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In healthy men, the oxytocin group showed no differential effect of monetary versus social feedback on procedural learning, whereas in the placebo group monetary feedback improved learning.

    In plain wordsIn healthy men given oxytocin, money feedback did not help learning more than social feedback, unlike in the placebo group.

    Peptide
    Oxytocin
    Outcome
    DecreaseEffect of monetary feedback on procedural learning
    Study

    n = 61

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    In contrast, the oxytocin group did not show a differential effect of monetary or social feedback despite a significant increase in oxytocin plasma levels after intranasal application.
    3 context sentences
    Summary · context
    For the placebo group, monetary feedback improved procedural learning compared to a neutral control condition.
    Summary · context
    In a randomized, double-blind, placebo-controlled trial, we investigated whether oxytocin modulates the differential effects of monetary and social feedback on procedural learning.
    Summary · context
    Sixty-one healthy male participants were randomized to receive a placebo or oxytocin intranasally.
  4. 04HumanRandomized controlled trialPharmacokinetics

    In healthy men, plasma oxytocin concentrations rose significantly after intranasal oxytocin application.

    In plain wordsIn healthy men, oxytocin levels in blood rose after oxytocin spray.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin plasma concentration after intranasal application
    Study

    n = 61

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    a significant increase in oxytocin plasma levels after intranasal application.
    3 context sentences
    Summary · context
    Oxytocin plasma concentrations were measured before and after applying the placebo or verum.
    Summary · context
    In a randomized, double-blind, placebo-controlled trial, we investigated whether oxytocin modulates the differential effects of monetary and social feedback on procedural learning.
    Summary · context
    Sixty-one healthy male participants were randomized to receive a placebo or oxytocin intranasally.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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