Cerebrolysin® and Environmental Enrichment, Alone or in Combination, Ameliorate Anxiety- and Depressive-Like Behaviors in a Post-Ischemic Depression Model in Mice.

Farajdokht F, Oghbaei F, Sadigh-Eteghad S, Majdi A, Aghsan SR, Farhoudi M, Vahidi-Eyrisofla N, Mahmoudi J

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association29 Apr 2022Cited by 16 (Europe PMC)

PMID35500360DOI10.1016/j.jstrokecerebrovasdis.2022.106519PepBankPUB-35500360

Publisher page PubMedAsk about this study

Jump to 10 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone10

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

01AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In mice, CBL and/or environmental enrichment reversed PID-induced anxiety-like behavior.
In plain wordsIn mice, CBL and/or environmental enrichment reduced anxiety-like behavior compared with the PID model.
Peptide
Cerebrolysin
Outcome
DecreaseAnxiety-like behavior
Study
micen: not reported in source
Post-ischemic depression
Comparator
PID model
Outcome group
Anxiety and mood · Mental health and mood
Source sentences
Summary
However, treatment with CBL and/or EE reversed behavioral and molecular changes induced by PID.
2 context sentences(design, population, supporting numbers)
Summary · context
PID model induced anxiety- and depressive-like behaviors and impaired social behavior.
Summary · context
Animals in the treatment groups received CBL (2.5 ml/kg) and/or were housed in EE (2 h/day) for two weeks.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3550036001
02AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In mice, CBL and/or environmental enrichment reversed PID-induced depressive-like behavior.
In plain wordsIn mice, CBL and/or environmental enrichment reduced depressive-like behavior compared with the PID model.
Peptide
Cerebrolysin
Outcome
DecreaseDepressive-like behavior
Study
micen: not reported in source
Post-ischemic depression
Comparator
PID model
Outcome group
Anxiety and mood · Mental health and mood
Source sentences
Summary
However, treatment with CBL and/or EE reversed behavioral and molecular changes induced by PID.
2 context sentences(design, population, supporting numbers)
Summary · context
PID model induced anxiety- and depressive-like behaviors and impaired social behavior.
Summary · context
Animals in the treatment groups received CBL (2.5 ml/kg) and/or were housed in EE (2 h/day) for two weeks.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3550036002
03AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In mice, CBL and/or environmental enrichment reversed PID-induced social impairment.
In plain wordsIn mice, CBL and/or environmental enrichment improved social behavior compared with the PID model.
Peptide
Cerebrolysin
Outcome
IncreaseSocial behavior
Study
micen: not reported in source
Post-ischemic depression
Comparator
PID model
Outcome group
Anxiety and mood · Mental health and mood
Source sentences
Summary
However, treatment with CBL and/or EE reversed behavioral and molecular changes induced by PID.
2 context sentences(design, population, supporting numbers)
Summary · context
PID model induced anxiety- and depressive-like behaviors and impaired social behavior.
Summary · context
Animals in the treatment groups received CBL (2.5 ml/kg) and/or were housed in EE (2 h/day) for two weeks.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3550036003
04AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In mice, CBL and/or environmental enrichment reversed the PID-induced increase in serum corticosterone.
In plain wordsIn mice, CBL and/or environmental enrichment reduced corticosterone compared with the PID model.
Peptide
Cerebrolysin
Outcome
DecreaseSerum corticosterone
Study
micen: not reported in source
Post-ischemic depression
Comparator
PID model
Outcome group
Stress hormones · Endocrine and hormones
Source sentences
Summary
However, treatment with CBL and/or EE reversed behavioral and molecular changes induced by PID.
2 context sentences(design, population, supporting numbers)
Summary · context
These behavioral changes were accompanied by increased serum corticosterone level
Summary · context
Animals in the treatment groups received CBL (2.5 ml/kg) and/or were housed in EE (2 h/day) for two weeks.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3550036004
05AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In mice, CBL and/or environmental enrichment reversed the PID-induced increase in lipid peroxidation.
In plain wordsIn mice, CBL and/or environmental enrichment reduced lipid peroxidation compared with the PID model.
Peptide
Cerebrolysin
Outcome
DecreaseLipid peroxidation
Study
micen: not reported in source
Post-ischemic depression
Comparator
PID model
Outcome group
Oxidative stress · Nervous system and cognition
Source sentences
Summary
However, treatment with CBL and/or EE reversed behavioral and molecular changes induced by PID.
2 context sentences(design, population, supporting numbers)
Summary · context
increased lipid peroxidation
Summary · context
Animals in the treatment groups received CBL (2.5 ml/kg) and/or were housed in EE (2 h/day) for two weeks.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3550036005
06AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In mice, CBL and/or environmental enrichment reversed the PID-induced decrease in antioxidant enzyme activities.
In plain wordsIn mice, CBL and/or environmental enrichment increased antioxidant enzyme activities compared with the PID model.
Peptide
Cerebrolysin
Outcome
IncreaseAntioxidant enzyme activities
Study
micen: not reported in source
Post-ischemic depression
Comparator
PID model
Outcome group
Oxidative stress · Nervous system and cognition
Source sentences
Summary
However, treatment with CBL and/or EE reversed behavioral and molecular changes induced by PID.
2 context sentences(design, population, supporting numbers)
Summary · context
decreased antioxidant enzyme activities
Summary · context
Animals in the treatment groups received CBL (2.5 ml/kg) and/or were housed in EE (2 h/day) for two weeks.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3550036006
07AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In mice, CBL and/or environmental enrichment reversed the PID-induced decrease in BDNF levels.
In plain wordsIn mice, CBL and/or environmental enrichment increased BDNF levels compared with the PID model.
Peptide
Cerebrolysin
Outcome
IncreaseBDNF levels
Study
micen: not reported in source
Post-ischemic depression
Comparator
PID model
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
However, treatment with CBL and/or EE reversed behavioral and molecular changes induced by PID.
2 context sentences(design, population, supporting numbers)
Summary · context
reduced BDNF levels
Summary · context
Animals in the treatment groups received CBL (2.5 ml/kg) and/or were housed in EE (2 h/day) for two weeks.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3550036007
08AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In mice, CBL and/or environmental enrichment reversed the PID-induced decrease in p-CREB/CREB ratio.
In plain wordsIn mice, CBL and/or environmental enrichment increased p-CREB/CREB ratio compared with the PID model.
Peptide
Cerebrolysin
Outcome
Increasep-CREB/CREB ratio
Study
micen: not reported in source
Post-ischemic depression
Comparator
PID model
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
However, treatment with CBL and/or EE reversed behavioral and molecular changes induced by PID.
2 context sentences(design, population, supporting numbers)
Summary · context
reduced BDNF levels and p-CREB/CREB ratio
Summary · context
Animals in the treatment groups received CBL (2.5 ml/kg) and/or were housed in EE (2 h/day) for two weeks.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3550036008
09AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In mice, CBL and/or environmental enrichment reversed the PID-induced increase in hippocampal NF-κB protein.
In plain wordsIn mice, CBL and/or environmental enrichment reduced NF-κB protein compared with the PID model.
Peptide
Cerebrolysin
Outcome
DecreaseNF-κB protein
Study
micen: not reported in source
Post-ischemic depression
Comparator
PID model
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
However, treatment with CBL and/or EE reversed behavioral and molecular changes induced by PID.
2 context sentences(design, population, supporting numbers)
Summary · context
and increased protein levels of NF-κB and Iba-1 in the hippocampus.
Summary · context
Animals in the treatment groups received CBL (2.5 ml/kg) and/or were housed in EE (2 h/day) for two weeks.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3550036009
10AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In mice, CBL and/or environmental enrichment reversed the PID-induced increase in hippocampal Iba-1 protein.
In plain wordsIn mice, CBL and/or environmental enrichment reduced Iba-1 protein compared with the PID model.
Peptide
Cerebrolysin
Outcome
DecreaseIba-1 protein
Study
micen: not reported in source
Post-ischemic depression
Comparator
PID model
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
However, treatment with CBL and/or EE reversed behavioral and molecular changes induced by PID.
2 context sentences(design, population, supporting numbers)
Summary · context
and increased protein levels of NF-κB and Iba-1 in the hippocampus.
Summary · context
Animals in the treatment groups received CBL (2.5 ml/kg) and/or were housed in EE (2 h/day) for two weeks.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3550036010

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

PepBank is a research reference. Talk to a doctor before you use any peptide.