Skip to content

Study · Randomized controlled trial · 2023

3 results

The role of oxytocin in modulating self-other distinction in human brain: a pharmacological fMRI study.

Wang Y, Wang R, Wu H

Cerebral cortex (New York, N.Y. : 1991)1 Feb 2023Cited by 2 (Europe PMC)

PMID35483708 (opens in a new tab)DOI10.1093/cercor/bhac167 (opens in a new tab)PepBankPUB-35483708
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In a double-blind fMRI study, the oxytocin group showed increased activity in visual areas and the inferior frontal gyrus for self-faces compared with placebo.

    In plain wordsIn an fMRI study, people given oxytocin showed more activity in visual and frontal brain areas when seeing their own face than people given placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseBrain activity for self-faces (fMRI)
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, fMRI results showed that the OT group exhibited increased activity in visual areas and the inferior frontal gyrus for self-faces.
    2 context sentences
    Summary · context
    This double-blind, placebo-controlled study investigated the effect of OT on self-face perception at the behavioral and neural levels.
    Summary · context
    After treatment with either OT or placebo, participants reported whether a stimulus resembled themselves while being scanned using functional magnetic resonance imaging (fMRI).
  2. 02HumanRandomized controlled trialEfficacy outcome

    In the same fMRI study, the oxytocin-related increase in activity for self-faces was more pronounced in the adult-face condition.

    In plain wordsIn the fMRI study, the oxytocin-related rise in brain activity for own-face images was stronger when the other face was an adult.

    Peptide
    Oxytocin
    Outcome
    IncreaseBrain activity for self-faces, adult-face condition
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This difference was more pronounced in the adult-face condition.
    2 context sentences
    Summary · context
    This double-blind, placebo-controlled study investigated the effect of OT on self-face perception at the behavioral and neural levels.
    Summary · context
    After treatment with either OT or placebo, participants reported whether a stimulus resembled themselves while being scanned using functional magnetic resonance imaging (fMRI).
  3. 03HumanRandomized controlled trialEfficacy outcome

    In multivariate fMRI and region-of-interest analyses, oxytocin increased self-other distinction compared with placebo, especially for adult faces and in the left hemisphere.

    In plain wordsIn an fMRI study, oxytocin increased how well people told their own face from others, compared with placebo, mostly for adult faces.

    Peptide
    Oxytocin
    Outcome
    IncreaseSelf-other distinction (multivariate fMRI and ROI analyses)
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In multivariate fMRI and region of interest analyses, better performance in the OT group indicated that OT increased self-other distinction, especially for adult faces and in the left hemisphere.
    2 context sentences
    Summary · context
    This double-blind, placebo-controlled study investigated the effect of OT on self-face perception at the behavioral and neural levels.
    Summary · context
    After treatment with either OT or placebo, participants reported whether a stimulus resembled themselves while being scanned using functional magnetic resonance imaging (fMRI).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.