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Study · Measured the body's own peptide · 2022

9 results

Peripheral oxytocin concentrations in psychiatric disorders - A systematic review and methanalysis: Further evidence.

Ferreira AC, Osório FL

Progress in neuro-psychopharmacology & biological psychiatry21 Apr 2022Cited by 37 (Europe PMC)

PMID35461971 (opens in a new tab)DOI10.1016/j.pnpbp.2022.110561 (opens in a new tab)PepBankPUB-35461971
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

No result from this study comes from a test of the peptide.

Natural levels measured9

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelSystematic reviewOther

    In meta-analysis, people with schizophrenia had lower peripheral oxytocin concentrations than healthy controls.

    In plain wordsPeople with schizophrenia had lower levels of the body's own oxytocin in blood than healthy people.

    Peptide
    Oxytocin
    Outcome
    DecreasePeripheral OXT concentration in schizophrenia
    Study

    n: not reported in source

    Comparator
    Healthy controls
    Outcome group
    Endogenous peptide levels · Mental health and mood

    Source sentences

    Summary
    Lower OXT concentrations were found in groups of specific disorders (i.e., schizophrenia, restricting and binge-eating/purging subtypes of anorexia nervosa, and borderline personality disorder) with medium to large effect sizes.
    2 context sentences
    Summary · context
    We present a systematic literature review followed by meta-analyses assessing whether peripheral oxytocin (OXT) levels among psychiatric patients differ from healthy controls, considering the moderating role of methodological aspects and samples' characteristics.
    Summary · context
    Fifty-five papers were included in the analysis, and nine independent meta-analyses were performed according to the different diagnoses.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelSystematic reviewOther

    In meta-analysis, people with restricting and binge-eating/purging anorexia nervosa had lower peripheral oxytocin concentrations than healthy controls.

    In plain wordsPeople with these types of anorexia nervosa had lower levels of the body's own oxytocin than healthy people.

    Peptide
    Oxytocin
    Outcome
    DecreasePeripheral OXT concentration in anorexia nervosa (restricting and binge-eating/purging subtypes)
    Study

    n: not reported in source

    Comparator
    Healthy controls
    Outcome group
    Endogenous peptide levels · Mental health and mood

    Source sentences

    Summary
    Lower OXT concentrations were found in groups of specific disorders (i.e., schizophrenia, restricting and binge-eating/purging subtypes of anorexia nervosa, and borderline personality disorder) with medium to large effect sizes.
    2 context sentences
    Summary · context
    We present a systematic literature review followed by meta-analyses assessing whether peripheral oxytocin (OXT) levels among psychiatric patients differ from healthy controls, considering the moderating role of methodological aspects and samples' characteristics.
    Summary · context
    Fifty-five papers were included in the analysis, and nine independent meta-analyses were performed according to the different diagnoses.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelSystematic reviewOther

    In meta-analysis, people with borderline personality disorder had lower peripheral oxytocin concentrations than healthy controls.

    In plain wordsPeople with borderline personality disorder had lower levels of the body's own oxytocin than healthy people.

    Peptide
    Oxytocin
    Outcome
    DecreasePeripheral OXT concentration in borderline personality disorder
    Study

    n: not reported in source

    Comparator
    Healthy controls
    Outcome group
    Endogenous peptide levels · Mental health and mood

    Source sentences

    Summary
    Lower OXT concentrations were found in groups of specific disorders (i.e., schizophrenia, restricting and binge-eating/purging subtypes of anorexia nervosa, and borderline personality disorder) with medium to large effect sizes.
    2 context sentences
    Summary · context
    We present a systematic literature review followed by meta-analyses assessing whether peripheral oxytocin (OXT) levels among psychiatric patients differ from healthy controls, considering the moderating role of methodological aspects and samples' characteristics.
    Summary · context
    Fifty-five papers were included in the analysis, and nine independent meta-analyses were performed according to the different diagnoses.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelSystematic reviewOther

    In meta-analysis, people with bipolar disorder type I had higher peripheral oxytocin concentrations than healthy controls.

    In plain wordsPeople with bipolar disorder type I had higher levels of the body's own oxytocin than healthy people.

    Peptide
    Oxytocin
    Outcome
    IncreasePeripheral OXT concentration in bipolar disorder type I
    Study

    n: not reported in source

    Comparator
    Healthy controls
    Outcome group
    Endogenous peptide levels · Mental health and mood

    Source sentences

    Summary
    High OXT levels with an effect size of the same magnitude were found for bipolar disorder - type I and obsessive disorder.
    2 context sentences
    Summary · context
    We present a systematic literature review followed by meta-analyses assessing whether peripheral oxytocin (OXT) levels among psychiatric patients differ from healthy controls, considering the moderating role of methodological aspects and samples' characteristics.
    Summary · context
    Fifty-five papers were included in the analysis, and nine independent meta-analyses were performed according to the different diagnoses.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  5. 05HumanEndogenous levelSystematic reviewOther

    In meta-analysis, people with obsessive disorder had higher peripheral oxytocin concentrations than healthy controls.

    In plain wordsPeople with obsessive disorder had higher levels of the body's own oxytocin than healthy people.

    Peptide
    Oxytocin
    Outcome
    IncreasePeripheral OXT concentration in obsessive disorder
    Study

    n: not reported in source

    Comparator
    Healthy controls
    Outcome group
    Endogenous peptide levels · Mental health and mood

    Source sentences

    Summary
    High OXT levels with an effect size of the same magnitude were found for bipolar disorder - type I and obsessive disorder.
    2 context sentences
    Summary · context
    We present a systematic literature review followed by meta-analyses assessing whether peripheral oxytocin (OXT) levels among psychiatric patients differ from healthy controls, considering the moderating role of methodological aspects and samples' characteristics.
    Summary · context
    Fifty-five papers were included in the analysis, and nine independent meta-analyses were performed according to the different diagnoses.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  6. 06HumanEndogenous levelSystematic reviewOther

    In meta-analysis, peripheral oxytocin concentrations did not differ between people with bulimia and healthy controls.

    In plain wordsPeople with bulimia and healthy people had similar levels of the body's own oxytocin.

    Peptide
    Oxytocin
    Outcome
    No significant changePeripheral OXT concentration in bulimia
    Study

    n: not reported in source

    Comparator
    Healthy controls
    Outcome group
    Endogenous peptide levels · Mental health and mood

    Source sentences

    Summary
    In contrast, no differences were found for bulimia, autism spectrum, depression, or social anxiety.
    2 context sentences
    Summary · context
    We present a systematic literature review followed by meta-analyses assessing whether peripheral oxytocin (OXT) levels among psychiatric patients differ from healthy controls, considering the moderating role of methodological aspects and samples' characteristics.
    Summary · context
    Fifty-five papers were included in the analysis, and nine independent meta-analyses were performed according to the different diagnoses.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  7. 07HumanEndogenous levelSystematic reviewOther

    In meta-analysis, peripheral oxytocin concentrations did not differ between people with autism spectrum disorder and healthy controls.

    In plain wordsPeople with autism spectrum disorder and healthy people had similar levels of the body's own oxytocin.

    Peptide
    Oxytocin
    Outcome
    No significant changePeripheral OXT concentration in autism spectrum disorder
    Study

    n: not reported in source

    Comparator
    Healthy controls
    Outcome group
    Endogenous peptide levels · Mental health and mood

    Source sentences

    Summary
    In contrast, no differences were found for bulimia, autism spectrum, depression, or social anxiety.
    2 context sentences
    Summary · context
    We present a systematic literature review followed by meta-analyses assessing whether peripheral oxytocin (OXT) levels among psychiatric patients differ from healthy controls, considering the moderating role of methodological aspects and samples' characteristics.
    Summary · context
    Fifty-five papers were included in the analysis, and nine independent meta-analyses were performed according to the different diagnoses.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  8. 08HumanEndogenous levelSystematic reviewOther

    In meta-analysis, peripheral oxytocin concentrations did not differ between people with depression and healthy controls.

    In plain wordsPeople with depression and healthy people had similar levels of the body's own oxytocin.

    Peptide
    Oxytocin
    Outcome
    No significant changePeripheral OXT concentration in depression
    Study

    n: not reported in source

    Comparator
    Healthy controls
    Outcome group
    Endogenous peptide levels · Mental health and mood

    Source sentences

    Summary
    In contrast, no differences were found for bulimia, autism spectrum, depression, or social anxiety.
    2 context sentences
    Summary · context
    We present a systematic literature review followed by meta-analyses assessing whether peripheral oxytocin (OXT) levels among psychiatric patients differ from healthy controls, considering the moderating role of methodological aspects and samples' characteristics.
    Summary · context
    Fifty-five papers were included in the analysis, and nine independent meta-analyses were performed according to the different diagnoses.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  9. 09HumanEndogenous levelSystematic reviewOther

    In meta-analysis, peripheral oxytocin concentrations did not differ between people with social anxiety and healthy controls.

    In plain wordsPeople with social anxiety and healthy people had similar levels of the body's own oxytocin.

    Peptide
    Oxytocin
    Outcome
    No significant changePeripheral OXT concentration in social anxiety
    Study

    n: not reported in source

    Comparator
    Healthy controls
    Outcome group
    Endogenous peptide levels · Mental health and mood

    Source sentences

    Summary
    In contrast, no differences were found for bulimia, autism spectrum, depression, or social anxiety.
    2 context sentences
    Summary · context
    We present a systematic literature review followed by meta-analyses assessing whether peripheral oxytocin (OXT) levels among psychiatric patients differ from healthy controls, considering the moderating role of methodological aspects and samples' characteristics.
    Summary · context
    Fifty-five papers were included in the analysis, and nine independent meta-analyses were performed according to the different diagnoses.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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