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Study · Randomized controlled trial · n = 70 · 2022

4 results

Effects of oxytocin and vasopressin administration on human fathers' sensitive and challenging parenting: A randomized within-subject controlled trial.

Witte AM, de Moor MHM, Majdandžić M, Verhees MWFT, van IJzendoorn MH, Bakermans-Kranenburg MJ

Hormones and behavior14 Apr 2022Cited by 6 (Europe PMC)

PMID35430502 (opens in a new tab)DOI10.1016/j.yhbeh.2022.105175 (opens in a new tab)PepBankPUB-35430502
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In fathers of infants, intranasal oxytocin made fathers less sensitive during a free play task than placebo.

    In plain wordsIn fathers of infants, oxytocin made fathers less sensitive during play than placebo did.

    Peptide
    Oxytocin
    Outcome
    DecreasePaternal sensitivity during free play
    Study

    n = 70

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Fathers in the oxytocin condition were less sensitive than fathers in the placebo condition
    2 context sentences
    Summary · context
    The sample consisted of 70 fathers with their 2- to 12-month-old infants.
    Summary · context
    All fathers were assigned to each of the three experimental sessions (oxytocin, vasopressin, and placebo), on three separate days, with random order and intervening periods of one to two weeks.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In fathers of infants, intranasal oxytocin did not change challenging parenting behaviors compared with placebo.

    In plain wordsIn fathers of infants, oxytocin did not change challenging parenting behaviors compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeChallenging parenting behaviors (CPB)
    Study

    n = 70

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    No effects were found of oxytocin and vasopressin administration on fathers' CPB.
    2 context sentences
    Summary · context
    The sample consisted of 70 fathers with their 2- to 12-month-old infants.
    Summary · context
    All fathers were assigned to each of the three experimental sessions (oxytocin, vasopressin, and placebo), on three separate days, with random order and intervening periods of one to two weeks.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In fathers who reported more parental love withdrawal in their own childhood, oxytocin lowered sensitivity compared with placebo.

    In plain wordsIn fathers who felt more parental love withdrawal as children, oxytocin lowered sensitive parenting compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreasePaternal sensitivity, moderated by high parental love withdrawal in childhood
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Fathers who reported higher levels of experienced parental love withdrawal were less sensitive in the oxytocin condition as compared to the placebo condition
    2 context sentences
    Summary · context
    The sample consisted of 70 fathers with their 2- to 12-month-old infants.
    Summary · context
    All fathers were assigned to each of the three experimental sessions (oxytocin, vasopressin, and placebo), on three separate days, with random order and intervening periods of one to two weeks.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In fathers who reported less parental love withdrawal in their own childhood, oxytocin and placebo gave no difference in sensitivity.

    In plain wordsIn fathers who felt less parental love withdrawal as children, oxytocin and placebo gave the same level of sensitive parenting.

    Peptide
    Oxytocin
    Outcome
    No significant changePaternal sensitivity, moderated by low parental love withdrawal in childhood
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    whereas fathers with less experienced parental love withdrawal showed no difference in sensitivity between the oxytocin and placebo condition
    2 context sentences
    Summary · context
    The sample consisted of 70 fathers with their 2- to 12-month-old infants.
    Summary · context
    All fathers were assigned to each of the three experimental sessions (oxytocin, vasopressin, and placebo), on three separate days, with random order and intervening periods of one to two weeks.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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