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Study · Animal study (in vivo) · rat · 2022

9 results

Abaloparatide Improves Rotator Cuff Healing via Anabolic Effects on Bone Remodeling in a Chronic Rotator Cuff Tear Model of Rat With Osteoporosis: A Comparison With Denosumab.

Xu J, Ye Z, Chen C, Zhang X, Han K, Wu X, Li Z, Jiang J, Yan X, Cai J, Zhao J

The American journal of sports medicine11 Apr 2022Cited by 34 (Europe PMC)

PMID35404150 (opens in a new tab)DOI10.1177/03635465221079651 (opens in a new tab)PepBankPUB-35404150
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In osteoporotic rats after cuff repair, abaloparatide increased failure load versus control.

    In plain wordsIn rats with osteoporosis after cuff repair, abaloparatide increased failure load compared with control.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseFailure load versus control
    Study

    ratn: not reported in source

    Ovariectomized osteoporotic rats with repaired chronic rotator cuff tear
    Comparator
    Control
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneous · 8 weeksAs given in this study (rat).

    Source sentences

    Summary
    At 8 weeks, significantly higher failure load and stiffness were observed in the ABL (25.13 ± 3.54 N, P < .001; 21.65 ± 3.08 N/mm, P < .001; respectively),
    3 context sentences
    Summary · context
    groups than in the CON group (13.36 ± 1.70 N; 11.20 ± 2.59 N/mm; respectively),
    Summary · context
    A chronic rotator cuff tear model was established in ovariectomy-induced postmenopausal osteoporotic rats.
    Summary · context
    Then, bilateral rotator cuff repairs were conducted in all experimental rats, which were randomly divided into control (CON), Dmab, and ABL groups to receive the corresponding subcutaneous injections.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In osteoporotic rats after cuff repair, abaloparatide increased stiffness versus control.

    In plain wordsIn rats with osteoporosis after cuff repair, abaloparatide increased stiffness compared with control.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseStiffness versus control
    Study

    ratn: not reported in source

    Ovariectomized osteoporotic rats with repaired chronic rotator cuff tear
    Comparator
    Control
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneous · 8 weeksAs given in this study (rat).

    Source sentences

    Summary
    At 8 weeks, significantly higher failure load and stiffness were observed in the ABL (25.13 ± 3.54 N, P < .001; 21.65 ± 3.08 N/mm, P < .001; respectively),
    3 context sentences
    Summary · context
    groups than in the CON group (13.36 ± 1.70 N; 11.20 ± 2.59 N/mm; respectively),
    Summary · context
    A chronic rotator cuff tear model was established in ovariectomy-induced postmenopausal osteoporotic rats.
    Summary · context
    Then, bilateral rotator cuff repairs were conducted in all experimental rats, which were randomly divided into control (CON), Dmab, and ABL groups to receive the corresponding subcutaneous injections.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In osteoporotic rats after cuff repair, abaloparatide produced better failure load than denosumab.

    In plain wordsIn rats with osteoporosis after cuff repair, abaloparatide produced better failure load than denosumab.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseFailure load versus denosumab
    Study

    ratn: not reported in source

    Ovariectomized osteoporotic rats with repaired chronic rotator cuff tear
    Comparator
    Denosumab
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneous · 8 weeksAs given in this study (rat).

    Source sentences

    Summary
    whereas the ABL treatment provided better failure load and stiffness than Dmab (P = .019; P = .003).
    2 context sentences
    Summary · context
    A chronic rotator cuff tear model was established in ovariectomy-induced postmenopausal osteoporotic rats.
    Summary · context
    Then, bilateral rotator cuff repairs were conducted in all experimental rats, which were randomly divided into control (CON), Dmab, and ABL groups to receive the corresponding subcutaneous injections.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In osteoporotic rats after cuff repair, abaloparatide produced better stiffness than denosumab.

    In plain wordsIn rats with osteoporosis after cuff repair, abaloparatide produced better stiffness than denosumab.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseStiffness versus denosumab
    Study

    ratn: not reported in source

    Ovariectomized osteoporotic rats with repaired chronic rotator cuff tear
    Comparator
    Denosumab
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneous · 8 weeksAs given in this study (rat).

    Source sentences

    Summary
    whereas the ABL treatment provided better failure load and stiffness than Dmab (P = .019; P = .003).
    2 context sentences
    Summary · context
    A chronic rotator cuff tear model was established in ovariectomy-induced postmenopausal osteoporotic rats.
    Summary · context
    Then, bilateral rotator cuff repairs were conducted in all experimental rats, which were randomly divided into control (CON), Dmab, and ABL groups to receive the corresponding subcutaneous injections.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In osteoporotic rats after cuff repair, abaloparatide showed the most mature tendon insertion, with more organized collagen and fibrocartilage and higher bone quality.

    In plain wordsIn rats with osteoporosis after cuff repair, abaloparatide produced the most mature tendon insertion among the groups.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseTendon insertion maturity
    Study

    ratn: not reported in source

    Ovariectomized osteoporotic rats with repaired chronic rotator cuff tear
    Comparator
    Control and denosumab
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    Although tendon-to-bone healing was improved by Dmab, the most mature tendon insertion at the interface was observed in the ABL group, including a more organized collagen and fibrocartilage and higher bone quality.
    2 context sentences
    Summary · context
    A chronic rotator cuff tear model was established in ovariectomy-induced postmenopausal osteoporotic rats.
    Summary · context
    Then, bilateral rotator cuff repairs were conducted in all experimental rats, which were randomly divided into control (CON), Dmab, and ABL groups to receive the corresponding subcutaneous injections.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In osteoporotic rats after cuff repair, abaloparatide increased osteoblast to osteoclast ratio compared with denosumab.

    In plain wordsIn rats with osteoporosis after cuff repair, abaloparatide increased the bone-building to bone-removing cell ratio compared with denosumab.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseOsteoblast to osteoclast ratio
    Study

    ratn: not reported in source

    Ovariectomized osteoporotic rats with repaired chronic rotator cuff tear
    Comparator
    Denosumab
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneous · 2 weeksAs given in this study (rat).

    Source sentences

    Summary
    ABL significantly promoted bone remodeling via coupling between osteoclasts and osteoblasts (osteoblast to osteoclast ratio: 4.80 ± 0.39; P = .022), thereby stimulating more new bone formation and mineralization at the tendon-to-bone healing interface than Dmab (osteoblast to osteoclast ratio…
    2 context sentences
    Summary · context
    A chronic rotator cuff tear model was established in ovariectomy-induced postmenopausal osteoporotic rats.
    Summary · context
    Then, bilateral rotator cuff repairs were conducted in all experimental rats, which were randomly divided into control (CON), Dmab, and ABL groups to receive the corresponding subcutaneous injections.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In osteoporotic rats after cuff repair, abaloparatide stimulated more new bone formation than denosumab.

    In plain wordsIn rats with osteoporosis after cuff repair, abaloparatide stimulated more new bone formation than denosumab.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseNew bone formation
    Study

    ratn: not reported in source

    Ovariectomized osteoporotic rats with repaired chronic rotator cuff tear
    Comparator
    Denosumab
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneous · 2 weeksAs given in this study (rat).

    Source sentences

    Summary
    ABL significantly promoted bone remodeling via coupling between osteoclasts and osteoblasts (osteoblast to osteoclast ratio: 4.80 ± 0.39; P = .022), thereby stimulating more new bone formation and mineralization at the tendon-to-bone healing interface than Dmab (osteoblast to osteoclast ratio…
    2 context sentences
    Summary · context
    A chronic rotator cuff tear model was established in ovariectomy-induced postmenopausal osteoporotic rats.
    Summary · context
    Then, bilateral rotator cuff repairs were conducted in all experimental rats, which were randomly divided into control (CON), Dmab, and ABL groups to receive the corresponding subcutaneous injections.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In osteoporotic rats after cuff repair, abaloparatide stimulated more mineralization than denosumab.

    In plain wordsIn rats with osteoporosis after cuff repair, abaloparatide stimulated more mineralization than denosumab.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseMineralization
    Study

    ratn: not reported in source

    Ovariectomized osteoporotic rats with repaired chronic rotator cuff tear
    Comparator
    Denosumab
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneous · 2 weeksAs given in this study (rat).

    Source sentences

    Summary
    ABL significantly promoted bone remodeling via coupling between osteoclasts and osteoblasts (osteoblast to osteoclast ratio: 4.80 ± 0.39; P = .022), thereby stimulating more new bone formation and mineralization at the tendon-to-bone healing interface than Dmab (osteoblast to osteoclast ratio…
    2 context sentences
    Summary · context
    A chronic rotator cuff tear model was established in ovariectomy-induced postmenopausal osteoporotic rats.
    Summary · context
    Then, bilateral rotator cuff repairs were conducted in all experimental rats, which were randomly divided into control (CON), Dmab, and ABL groups to receive the corresponding subcutaneous injections.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In osteoporotic rats, abaloparatide significantly affected osteogenesis and chondrogenesis gene expression versus control and denosumab.

    In plain wordsIn rats with osteoporosis, abaloparatide changed bone and cartilage gene activity compared with control and denosumab.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    MixedOsteogenesis and chondrogenesis gene expression
    Study

    ratn: not reported in source

    Ovariectomized osteoporotic rats with repaired chronic rotator cuff tear
    Comparator
    Control and denosumab
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    Moreover, ABL had significant effects on gene expression [Runt-realted transcription factor 2 (Runx2, collagen type I-alpha 1 (Col1A1]), and sclerostin for osteogenesis; aggrecan and collagen type II (Col2) for chondrogenesis] in mineralized tissues, indicative of enhanced bone…
    2 context sentences
    Summary · context
    A chronic rotator cuff tear model was established in ovariectomy-induced postmenopausal osteoporotic rats.
    Summary · context
    Then, bilateral rotator cuff repairs were conducted in all experimental rats, which were randomly divided into control (CON), Dmab, and ABL groups to receive the corresponding subcutaneous injections.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

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