MOTS-c and Exercise Restore Cardiac Function by Activating of NRG1-ErbB Signaling in Diabetic Rats.

Li S, Wang M, Ma J, Pang X, Yuan J, Pan Y, Fu Y, Laher I

Frontiers in endocrinology17 Mar 2022Cited by 22 (Europe PMC)

PMID35370955PMCIDPMC8969227DOI10.3389/fendo.2022.812032PepBankPUB-35370955

Summary

Pathologic cardiac remodeling and dysfunction are the most common complications of type 2 diabetes. Physical exercise is important in inhibiting myocardial pathologic remodeling and restoring cardiac function in diabetes. The mitochondrial-derived peptide MOTS-c has exercise-like effects by improving insulin resistance, combatting hyperglycemia, and reducing lipid accumulation. We investigated the effects and transcriptomic profiling of MOTS-c and aerobic exercise on cardiac properties in a rat model of type 2 diabetes which was induced by feeding a high fat high sugar diet combined with an injection of a low dose of streptozotocin. Both aerobic exercise and MOTS-c treatment reduced abnormalities in cardiac structure and function. Transcriptomic function enrichment analysis revealed that MOTS-c had exercise-like effects on inflammation, myocardial apoptosis, angiogenesis and endothelial cell proliferation and migration, and showed that the NRG1-ErbB4 pathway might be an important component in both MOTS-c and exercise induced attenuation of cardiac dysfunction in diabetes. Moreover, our findings suggest that MOTS-c activates NRG1-ErbB4 signaling and mimics exercise-induced cardio-protection in diabetes.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, MOTS‑c treatment reduced abnormalities in cardiac structure.
In plain wordsIn diabetic rats, MOTS‑c treatment reduced abnormal changes in heart structure.
Peptide
MOTS-c
Outcome
DecreaseAbnormalities in cardiac structure
Study
ratn: not reported in source
Type 2 diabetes model (high fat high sugar diet plus low dose streptozotocin)
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Both aerobic exercise and MOTS-c treatment reduced abnormalities in cardiac structure and function.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the effects and transcriptomic profiling of MOTS-c and aerobic exercise on cardiac properties in a rat model of type 2 diabetes which was induced by feeding a high fat high sugar diet combined with an injection of a low dose of streptozotocin.
Show in the study text Report a problemFND-3537095501
02AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, MOTS‑c treatment reduced abnormalities in cardiac function.
In plain wordsIn diabetic rats, MOTS‑c treatment reduced abnormal changes in heart function.
Peptide
MOTS-c
Outcome
DecreaseAbnormalities in cardiac function
Study
ratn: not reported in source
Type 2 diabetes model (high fat high sugar diet plus low dose streptozotocin)
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Both aerobic exercise and MOTS-c treatment reduced abnormalities in cardiac structure and function.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the effects and transcriptomic profiling of MOTS-c and aerobic exercise on cardiac properties in a rat model of type 2 diabetes which was induced by feeding a high fat high sugar diet combined with an injection of a low dose of streptozotocin.
Show in the study text Report a problemFND-3537095502
03AnimalAnimal study (in vivo)Mechanism
In diabetic rat hearts, transcriptomic analysis showed that MOTS‑c had exercise-like effects on inflammation.
In plain wordsIn diabetic rats, gene activity in the heart suggested MOTS‑c acts on inflammation in a way similar to exercise.
Peptide
MOTS-c
Outcome
Not applicableCardiac inflammation (transcriptomic enrichment)
Study
ratn: not reported in source
Type 2 diabetes model (high fat high sugar diet plus low dose streptozotocin)
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
MOTS-c had exercise-like effects on inflammation, myocardial apoptosis, angiogenesis and endothelial cell proliferation and migration
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the effects and transcriptomic profiling of MOTS-c and aerobic exercise on cardiac properties in a rat model of type 2 diabetes which was induced by feeding a high fat high sugar diet combined with an injection of a low dose of streptozotocin.
Show in the study text Report a problemFND-3537095503
04AnimalAnimal study (in vivo)Mechanism
In diabetic rat hearts, transcriptomic analysis showed that MOTS‑c had exercise-like effects on myocardial apoptosis.
In plain wordsIn diabetic rats, gene activity in the heart suggested MOTS‑c acts on heart cell death in a way similar to exercise.
Peptide
MOTS-c
Outcome
Not applicableMyocardial apoptosis (transcriptomic enrichment)
Study
ratn: not reported in source
Type 2 diabetes model (high fat high sugar diet plus low dose streptozotocin)
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
MOTS-c had exercise-like effects on inflammation, myocardial apoptosis, angiogenesis and endothelial cell proliferation and migration
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the effects and transcriptomic profiling of MOTS-c and aerobic exercise on cardiac properties in a rat model of type 2 diabetes which was induced by feeding a high fat high sugar diet combined with an injection of a low dose of streptozotocin.
Show in the study text Report a problemFND-3537095504
05AnimalAnimal study (in vivo)Mechanism
In diabetic rat hearts, transcriptomic analysis showed that MOTS‑c had exercise-like effects on angiogenesis.
In plain wordsIn diabetic rats, gene activity in the heart suggested MOTS‑c acts on new blood vessel growth in a way similar to exercise.
Peptide
MOTS-c
Outcome
Not applicableAngiogenesis (transcriptomic enrichment)
Study
ratn: not reported in source
Type 2 diabetes model (high fat high sugar diet plus low dose streptozotocin)
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
MOTS-c had exercise-like effects on inflammation, myocardial apoptosis, angiogenesis and endothelial cell proliferation and migration
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the effects and transcriptomic profiling of MOTS-c and aerobic exercise on cardiac properties in a rat model of type 2 diabetes which was induced by feeding a high fat high sugar diet combined with an injection of a low dose of streptozotocin.
Show in the study text Report a problemFND-3537095505
06AnimalAnimal study (in vivo)Mechanism
In diabetic rat hearts, transcriptomic analysis showed that MOTS‑c had exercise-like effects on endothelial cell proliferation and migration.
In plain wordsIn diabetic rats, gene activity in the heart suggested MOTS‑c acts on blood vessel lining cells in a way similar to exercise.
Peptide
MOTS-c
Outcome
Not applicableEndothelial cell proliferation and migration (transcriptomic enrichment)
Study
ratn: not reported in source
Type 2 diabetes model (high fat high sugar diet plus low dose streptozotocin)
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
MOTS-c had exercise-like effects on inflammation, myocardial apoptosis, angiogenesis and endothelial cell proliferation and migration
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the effects and transcriptomic profiling of MOTS-c and aerobic exercise on cardiac properties in a rat model of type 2 diabetes which was induced by feeding a high fat high sugar diet combined with an injection of a low dose of streptozotocin.
Show in the study text Report a problemFND-3537095506
07AnimalAnimal study (in vivo)Mechanism
In diabetic rats, MOTS‑c activated NRG1-ErbB4 signaling and mimicked exercise-induced cardio-protection.
In plain wordsIn diabetic rats, MOTS‑c switched on NRG1-ErbB4 signaling in the heart, as exercise does.
Peptide
MOTS-c
Outcome
IncreaseNRG1-ErbB4 signaling activation
Study
ratn: not reported in source
Type 2 diabetes model (high fat high sugar diet plus low dose streptozotocin)
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Moreover, our findings suggest that MOTS-c activates NRG1-ErbB4 signaling and mimics exercise-induced cardio-protection in diabetes.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the effects and transcriptomic profiling of MOTS-c and aerobic exercise on cardiac properties in a rat model of type 2 diabetes which was induced by feeding a high fat high sugar diet combined with an injection of a low dose of streptozotocin.
Show in the study text Report a problemFND-3537095507

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

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