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Study · Randomized controlled trial · n = 70 · 2022

3 results

The effects of oxytocin and vasopressin administration on fathers' neural responses to infant crying: A randomized controlled within-subject study.

Witte AM, Riem MME, van der Knaap N, de Moor MHM, van IJzendoorn MH, Bakermans-Kranenburg MJ

Psychoneuroendocrinology17 Mar 2022Cited by 7 (Europe PMC)

PMID35334388 (opens in a new tab)DOI10.1016/j.psyneuen.2022.105731 (opens in a new tab)PepBankPUB-35334388
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In first-time fathers, oxytocin administration did not significantly change whole-brain neural activation to infant cry sounds versus placebo.

    In plain wordsIn new fathers, oxytocin did not change overall brain responses to a crying infant compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeWhole-brain neural activation to infant cry sounds
    Study

    n = 70

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Whole brain analyses revealed no significant effect of vasopressin or oxytocin administration on neural activation in response to infant cry sounds.
    1 context sentence
    Summary · context
    In a randomized double-blind within-subject control study we investigated the effects of oxytocin and vasopressin administration on neural reactivity to infant cry sounds in 70 first-time fathers in the first year of fatherhood.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In first-time fathers, oxytocin administration decreased amygdala activation to infant cry sounds versus placebo in region of interest analyses.

    In plain wordsIn new fathers, oxytocin lowered amygdala brain activity in response to a crying infant compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseAmygdala activation to infant cry sounds (region of interest)
    Study

    n = 70

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Region of interest analyses showed decreased amygdala activation in both the oxytocin condition and the vasopressin condition as compared to placebo.
    1 context sentence
    Summary · context
    In a randomized double-blind within-subject control study we investigated the effects of oxytocin and vasopressin administration on neural reactivity to infant cry sounds in 70 first-time fathers in the first year of fatherhood.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In first-time fathers, early childhood experiences of harsh discipline and love withdrawal did not moderate the neural effects of oxytocin.

    In plain wordsIn new fathers, childhood experiences did not change how oxytocin affected brain responses to a crying infant.

    Peptide
    Oxytocin
    Outcome
    No significant changeModeration of oxytocin effects by early childhood experiences
    Study

    n = 70

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found no moderating effects of fathers' early childhood experiences.
    1 context sentence
    Summary · context
    In a randomized double-blind within-subject control study we investigated the effects of oxytocin and vasopressin administration on neural reactivity to infant cry sounds in 70 first-time fathers in the first year of fatherhood.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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