Efficacy of oxytocics on reducing intraoperative blood loss during abdominal myomectomy: A systematic review and meta-analysis of randomized placebo-controlled trials.

Albazee E, Sayad R, Elrashedy AA, Samy Z, Faraag E, Baradwan S, Samy A

Journal of gynecology obstetrics and human reproduction19 Mar 2022Cited by 8 (Europe PMC)

PMID35314367DOI10.1016/j.jogoh.2022.102358PepBankPUB-35314367

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

3 results from studies that gave the peptide. 3 results from people.

01HumanSystematic reviewEfficacy outcome
In women undergoing abdominal myomectomy, oxytocin alone (not carbetocin) was linked to higher postoperative hemoglobin versus control.
In plain wordsIn women having fibroid surgery, oxytocin, but not carbetocin, was linked to higher hemoglobin after surgery compared with control.
Peptide
Oxytocin
Outcome
IncreasePostoperative hemoglobin
Study
n: not reported in source
Comparator
Control group
Outcome group
Bleeding and clotting · Reproductive and sexual health
Studied dose
Dose not stated
Measurements
MD
0.6 g/dl
oxytocin subgroup
Source sentences
Summary
Subgroup analysis revealed that oxytocin, but not carbetocin, correlated with a reduced mean difference of postoperative hemoglobin (MD=0.60 g/dl, 95% CI [0.24 to 0.96], p=0.001), postoperative hematocrit (MD=2.29%, 95% CI [1.06, 3.52], p<0.001), and operation time (MD=-14.66 min, 95% CI [-21.04, -8…
2 context sentences(design, population, supporting numbers)
Summary · context
Only randomized placebo-controlled trials (RCTs) were considered.
Summary · context
Seven RCTs met the inclusion criteria (n=758 patients; 329 patients per group).
Report a problemFND-3531436704
02HumanSystematic reviewEfficacy outcome
In women undergoing abdominal myomectomy, oxytocin alone (not carbetocin) was linked to higher postoperative hematocrit versus control.
In plain wordsIn women having fibroid surgery, oxytocin, but not carbetocin, was linked to higher hematocrit after surgery compared with control.
Peptide
Oxytocin
Outcome
IncreasePostoperative hematocrit
Study
n: not reported in source
Comparator
Control group
Outcome group
Bleeding and clotting · Reproductive and sexual health
Studied dose
Dose not stated
Measurements
MD
2.29%
oxytocin subgroup
Source sentences
Summary
Subgroup analysis revealed that oxytocin, but not carbetocin, correlated with a reduced mean difference of postoperative hemoglobin (MD=0.60 g/dl, 95% CI [0.24 to 0.96], p=0.001), postoperative hematocrit (MD=2.29%, 95% CI [1.06, 3.52], p<0.001), and operation time (MD=-14.66 min, 95% CI [-21.04, -8…
2 context sentences(design, population, supporting numbers)
Summary · context
Only randomized placebo-controlled trials (RCTs) were considered.
Summary · context
Seven RCTs met the inclusion criteria (n=758 patients; 329 patients per group).
Report a problemFND-3531436705
03HumanSystematic reviewEfficacy outcome
In women undergoing abdominal myomectomy, oxytocin alone (not carbetocin) shortened operation time versus control.
In plain wordsIn women having fibroid surgery, oxytocin, but not carbetocin, shortened operation time compared with control.
Peptide
Oxytocin
Outcome
DecreaseOperation time
Study
n: not reported in source
Comparator
Control group
Outcome group
Bleeding and clotting · Reproductive and sexual health
Studied dose
Dose not stated
Measurements
MD
−14.66 min
oxytocin subgroup
Source sentences
Summary
Subgroup analysis revealed that oxytocin, but not carbetocin, correlated with a reduced mean difference of postoperative hemoglobin (MD=0.60 g/dl, 95% CI [0.24 to 0.96], p=0.001), postoperative hematocrit (MD=2.29%, 95% CI [1.06, 3.52], p<0.001), and operation time (MD=-14.66 min, 95% CI [-21.04, -8…
2 context sentences(design, population, supporting numbers)
Summary · context
Only randomized placebo-controlled trials (RCTs) were considered.
Summary · context
Seven RCTs met the inclusion criteria (n=758 patients; 329 patients per group).
Report a problemFND-3531436706

Studies that did not test the peptide alone3

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

04HumanNot a test of Oxytocin aloneSystematic reviewEfficacy outcome
In women undergoing abdominal myomectomy, pooled oxytocin and carbetocin lowered intraoperative blood loss versus control.
In plain wordsIn women having fibroid surgery, oxytocin and carbetocin together reduced blood loss compared with control.
Peptide
Oxytocin
Outcome
DecreaseIntraoperative blood loss
Study
n = 758
Comparator
Control group
Outcome group
Bleeding and clotting · Reproductive and sexual health
Measurements
MD
−281.08 ml
oxytocin and carbetocin pooled
Source sentences
Summary
oxytocin and carbetocin resulted in a significantly lower intraoperative blood loss (MD=-281.08 ml, 95% CI [-400.63, -161.53]
2 context sentences(design, population, supporting numbers)
Summary · context
Only randomized placebo-controlled trials (RCTs) were considered.
Summary · context
Seven RCTs met the inclusion criteria (n=758 patients; 329 patients per group).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-3531436701
05HumanNot a test of Oxytocin aloneSystematic reviewEfficacy outcome
In women undergoing abdominal myomectomy, pooled oxytocin and carbetocin shortened hospital stay versus control.
In plain wordsIn women having fibroid surgery, oxytocin and carbetocin together shortened hospital stay compared with control.
Peptide
Oxytocin
Outcome
DecreaseHospital stay
Study
n = 758
Comparator
Control group
Outcome group
Bleeding and clotting · Reproductive and sexual health
Measurements
MD
−0.21 days
oxytocin and carbetocin pooled
Source sentences
Summary
hospital stay (MD=-0.21 days, 95% CI [-0.31, -0.10]
2 context sentences(design, population, supporting numbers)
Summary · context
Only randomized placebo-controlled trials (RCTs) were considered.
Summary · context
Seven RCTs met the inclusion criteria (n=758 patients; 329 patients per group).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-3531436702
06HumanNot a test of Oxytocin aloneSystematic reviewEfficacy outcome
In women undergoing abdominal myomectomy, pooled oxytocin and carbetocin lowered the need for blood transfusion versus control.
In plain wordsIn women having fibroid surgery, oxytocin and carbetocin together lowered the need for blood transfusion compared with control.
Peptide
Oxytocin
Outcome
DecreaseNeed for blood transfusion
Study
n = 758
Comparator
Control group
Outcome group
Bleeding and clotting · Reproductive and sexual health
Measurements
RR
0.32 ratio
oxytocin and carbetocin pooled
Source sentences
Summary
need for blood transfusion (RR=0.32, 95% CI [0.22, 0.46]
2 context sentences(design, population, supporting numbers)
Summary · context
Only randomized placebo-controlled trials (RCTs) were considered.
Summary · context
Seven RCTs met the inclusion criteria (n=758 patients; 329 patients per group).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-3531436703

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 00:50 UTC
Study results updated
Version 1
9 Oct 2026, 02:48 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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