In brown adipocytes, conditioned medium from AICAR-treated C2C12 myotubes increased UCP1 expression.
In plain wordsIn cells, medium from AICAR-treated muscle cells increased UCP1 expression in brown fat cells.
- Peptide
- AICAR (acadesine)
- Outcome
- IncreaseUCP1 expression
- Study
n: not reported in source
Brown adipocytes exposed to conditioned medium from AICAR-treated C2C12 myotubes- Outcome group
- Receptor activity and mechanism · Metabolic and weight
Source sentences
To gain a better understanding of these mechanisms, we analysed the conditioned media obtained after treating the C2C12 myotubes with an AMP-activated protein kinase (AMPK) activator (AICAR; 5-aminoimidazole-4-carboxamide ribonucleotide), which leads to an increased expression of UCP1 when added to brown adipocytes.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).