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Study · Randomized controlled trial · n = 85 · 2022

3 results

Intranasal oxytocin modulates the salience network in aging.

Liu P, Lin T, Feifel D, Ebner NC

NeuroImage5 Mar 2022Cited by 10 (Europe PMC)

PMID35259525 (opens in a new tab)PMCIDPMC9450112 (opens in a new tab)DOI10.1016/j.neuroimage.2022.119045 (opens in a new tab)PepBankPUB-35259525
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In young and older adults, intranasal oxytocin lowered resting-state connectivity of the left amygdala within the ventral salience network versus placebo.

    In plain wordsIn young and older adults, intranasal oxytocin lowered brain connectivity between the left amygdala and a salience network compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseWithin-network functional connectivity, left amygdala in ventral salience network
    Study

    n = 85

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    individuals in the oxytocin compared to the placebo group had lower within-network resting-state functional connectivity, both for left amygdala (MNI coordinates: x = -18, y = 0, z = -15; corrected p < 0.05) within a more ventral salience network
    1 context sentence
    Summary · context
    To address this research gap, 42 young (22.52 ± 3.02 years; 24 in the oxytocin group) and 43 older (71.12 ± 5.25 years; 21 in the oxytocin group) participants were randomized to either self-administer intranasal oxytocin or placebo prior to resting-state functional imaging.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In young and older adults, intranasal oxytocin lowered resting-state connectivity of the right insula within the dorsal salience network versus placebo.

    In plain wordsIn young and older adults, intranasal oxytocin lowered brain connectivity of the right insula in a salience network compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseWithin-network functional connectivity, right insula in dorsal salience network
    Study

    n = 85

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    and for right insula (MNI coordinates: x = 39, y = 6, z = -6; corrected p < 0.05) within a more dorsal salience network
    1 context sentence
    Summary · context
    To address this research gap, 42 young (22.52 ± 3.02 years; 24 in the oxytocin group) and 43 older (71.12 ± 5.25 years; 21 in the oxytocin group) participants were randomized to either self-administer intranasal oxytocin or placebo prior to resting-state functional imaging.
  3. 03HumanRandomized controlled trialEfficacy outcome

    The oxytocin-related reduction in connectivity between the ventral salience network and the left amygdala was present only in older participants.

    In plain wordsOxytocin lowered amygdala connectivity in a salience network only in older adults, not in younger adults, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseAge moderation of amygdala connectivity change
    Study

    n = 43

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Age moderation analysis furthermore demonstrated that the oxytocin-reduced functional connectivity between the ventral salience network and the left amygdala was only present in older participants.
    1 context sentence
    Summary · context
    To address this research gap, 42 young (22.52 ± 3.02 years; 24 in the oxytocin group) and 43 older (71.12 ± 5.25 years; 21 in the oxytocin group) participants were randomized to either self-administer intranasal oxytocin or placebo prior to resting-state functional imaging.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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