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Study · Animal study (in vivo) · rat · 2022

4 results

A KPV-binding double-network hydrogel restores gut mucosal barrier in an inflamed colon.

Zhao Y, Xue P, Lin G, Tong M, Yang J, Zhang Y, Ran K, Zhuge D, Yao Q, Xu H

Acta biomaterialia1 Mar 2022Cited by 28 (Europe PMC)

PMID35245681 (opens in a new tab)DOI10.1016/j.actbio.2022.02.039 (opens in a new tab)PepBankPUB-35245681
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with TNBS-induced colitis, the colitis-alleviating effect of KPV was significantly improved when KPV was given with the PMSP hydrogel.

    In plain wordsIn rats with colitis, KPV eased colitis more when given in the PMSP gel than without the gel.

    Peptide
    KPV
    Outcome
    DecreaseColitis severity (KPV effect with PMSP versus without)
    Study

    ratn: not reported in source

    TNBS-induced ulcerative colitis rats
    Comparator
    KPV without PMSP hydrogel
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated · intracolonicAs given in this study (rat).

    Source sentences

    Summary
    Moreover, the alleviating effect of KPV on rats with TNBS-induced colitis was significantly improved by PMSP after intracolonic administration.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with TNBS-induced colitis, PMSP-KPV treatment effectively recovered the colonic epithelial barrier.

    In plain wordsIn rats with colitis, KPV in a gel helped the colon lining barrier recover.

    Peptide
    KPV
    Outcome
    IncreaseColonic epithelial barrier recovery
    Study

    ratn: not reported in source

    TNBS-induced ulcerative colitis rats
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated · intracolonicAs given in this study (rat).

    Source sentences

    Summary
    The epithelial barrier of the colon also effectively recovered following PMSP-KPV treatment.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with TNBS-induced colitis, PMSP-KPV markedly augmented the abundance of beneficial gut microorganisms.

    In plain wordsIn rats with colitis, KPV in a gel increased helpful gut microbes.

    Peptide
    KPV
    Outcome
    IncreaseAbundance of beneficial gut microorganisms
    Study

    ratn: not reported in source

    TNBS-induced ulcerative colitis rats
    Outcome group
    Gut microbiota · Gastrointestinal
    Studied dose
    Dose not stated · intracolonicAs given in this study (rat).

    Source sentences

    Summary
    PMSP-KPV also modulated the gut flora, markedly augmenting the abundance of beneficial microorganisms in gut homeostasis.

Studies that did not test the peptide alone1

In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking KPV.

  1. 04LabNot a test of KPV aloneOther designOther

    KPV captured by the PMSP hydrogel retained its bioactivity for a longer time under high temperature conditions.

    In plain wordsIn lab tests, the PMSP gel kept KPV active for longer when heated.

    Peptide
    KPV
    Outcome
    Not applicableKPV bioactivity retention at high temperature
    Study

    n: not reported in source

    Outcome group
    Formulation, delivery and stability · Pharmacology

    Source sentences

    Summary
    KPV (Lys-Pro-Val) as a model drug was easily captured by PMSP through electrostatic interactions, thus retaining its bioactivity for a longer time under high temperature conditions.

    In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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