In high-anxious individuals, low-frequency chronic intranasal oxytocin attenuated the increase in amygdala-insula-prefrontal reactivity to threatening but not positive stimuli seen with placebo.
In plain wordsIn highly anxious people, oxytocin nasal spray taken every other day reduced brain reactivity to threatening images compared with placebo.
- Peptide
- Oxytocin
- Outcome
- DecreaseNeural reactivity to threat in high-anxious subjects
- Study
n: not reported in source
- Comparator
- Placebo
- Outcome group
- Brain and neuronal activity · Nervous system and cognition
- Studied dose
- Dose not stated · intranasalAs given in this study (human).
Source sentences
OT produced valence, dose frequency, and trait anxiety-specific effects, such that the low-frequency (intermittent) chronic dosage specifically attenuated a neural reactivity increase in amygdala-insula-prefrontal circuits observed in the high anxious placebo-treated subjects in response to threaten…
1 context sentence(design, population, supporting numbers)
In a pre-registered double-blind randomized placebo-controlled pharmaco-fMRI trial the acute (single dose) as well as chronic effects of two different dose frequencies of OT (OT administered daily for 5 days or every other day) on emotional reactivity were assessed in n = 147 individuals with high v…