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Study · Measured the body's own peptide · 2022

2 results

Impact of social isolation on the oxytocinergic system: A systematic review and meta-analysis of rodent data.

Krimberg JS, Lumertz FS, Orso R, Viola TW, de Almeida RMM

Neuroscience and biobehavioral reviews21 Jan 2022Cited by 25 (Europe PMC)

PMID35074312 (opens in a new tab)DOI10.1016/j.neubiorev.2022.104549 (opens in a new tab)PepBankPUB-35074312
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In socially isolated rats and mice, no significant effects on oxytocin (OXT) levels were observed.

    In plain wordsIn rats and mice, social isolation did not significantly change the body's own oxytocin levels.

    Peptide
    Oxytocin
    Outcome
    No significant changeOXT levels after social isolation
    Study

    Rat and mousen: not reported in source

    Social isolation
    Comparator
    Non-isolated controls
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    No significant effects on OXT levels were observed.
    1 context sentence
    Summary · context
    We conducted a systematic review and meta-analysis to compile data about the effects of SI in the oxytocinergic system of rats and mice, and its relation to behavioral alterations.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Efficacy outcome

    In socially isolated rats and mice, synthetic oxytocin or its agonists partially decreased unwanted behaviors to levels similar to control animals.

    In plain wordsIn socially isolated rats and mice, giving oxytocin or similar drugs partly reduced unwanted behaviors toward the level of control animals.

    Peptide
    Oxytocin
    Outcome
    DecreaseBehaviors altered by social isolation
    Study

    Rat and mousen: not reported in source

    Social isolation
    Comparator
    Control animals
    Outcome group
    Anxiety and mood · Mental health and mood

    Source sentences

    Summary
    Administration of synthetic OXT or its agonists partially decreases those unwanted behaviors to similar levels of control animals.
    1 context sentence
    Summary · context
    We conducted a systematic review and meta-analysis to compile data about the effects of SI in the oxytocinergic system of rats and mice, and its relation to behavioral alterations.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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