Skip to content

Study · Animal study (in vivo) · rat · 2022

3 results

Sustained Release In Situ Thermogelling Hydrogel of Cerebrolysin for Treatment of Facial Nerve Axotomy in Rats.

Haggag MA, Salem AE, Elsherbini AM

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons23 Dec 2021Cited by 1 (Europe PMC)

PMID35041809 (opens in a new tab)DOI10.1016/j.joms.2021.12.008 (opens in a new tab)PepBankPUB-35041809
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with facial nerve axotomy, Cerebrolysin hydrogel enhanced Schwann growth compared with control, especially in the specified regimens.

    In plain wordsIn rats, Cerebrolysin hydrogel increased Schwann growth compared with control.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseSchwann growth
    Study

    ratsn: not reported in source

    Facial nerve axotomy
    Comparator
    Phosphate buffered saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10%, 15% single injection and 5% four injections · local applicationAs given in this study (rats).

    Source sentences

    Summary
    CBLH showed statistically significant FN regeneration by enhancing Schwann and axonal growth compared to control group especially with single injection of 10%, 15%, and 5% 4-time injections, where the P value was less than .001.
    3 context sentences
    Summary · context
    The authors implemented a randomized, controlled, blinded animal study.
    Summary · context
    Rest of the groups were injected with 5%, 10%, and 15% CBLH once in groups II, III, IV and weekly in groups VI, VII, and VIII.
    Summary · context
    This study evaluated local application of different concentrations and injection intervals of Cerebrolysin hydrogel (CBLH) for facial nerve axotomy (FNA) treatment.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with facial nerve axotomy, Cerebrolysin hydrogel enhanced axonal growth compared with control, especially in the specified regimens.

    In plain wordsIn rats, Cerebrolysin hydrogel increased axonal growth compared with control.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseAxonal growth
    Study

    ratsn: not reported in source

    Facial nerve axotomy
    Comparator
    Phosphate buffered saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10%, 15% single injection and 5% four injections · local applicationAs given in this study (rats).

    Source sentences

    Summary
    CBLH showed statistically significant FN regeneration by enhancing Schwann and axonal growth compared to control group especially with single injection of 10%, 15%, and 5% 4-time injections, where the P value was less than .001.
    3 context sentences
    Summary · context
    The authors implemented a randomized, controlled, blinded animal study.
    Summary · context
    Rest of the groups were injected with 5%, 10%, and 15% CBLH once in groups II, III, IV and weekly in groups VI, VII, and VIII.
    Summary · context
    This study evaluated local application of different concentrations and injection intervals of Cerebrolysin hydrogel (CBLH) for facial nerve axotomy (FNA) treatment.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with facial nerve axotomy, eye-blink improvement correlated with structural improvement associated with Cerebrolysin hydrogel.

    In plain wordsIn rats, better eye-blink reflex correlated with structural improvement associated with Cerebrolysin hydrogel.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseEye-blink reflex
    Study

    ratsn: not reported in source

    Facial nerve axotomy
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · local applicationAs given in this study (rats).

    Source sentences

    Summary
    Significant improvement of eye-blink reflex was correlated with structural improvement associated with CBLH.
    3 context sentences
    Summary · context
    The authors implemented a randomized, controlled, blinded animal study.
    Summary · context
    Rest of the groups were injected with 5%, 10%, and 15% CBLH once in groups II, III, IV and weekly in groups VI, VII, and VIII.
    Summary · context
    This study evaluated local application of different concentrations and injection intervals of Cerebrolysin hydrogel (CBLH) for facial nerve axotomy (FNA) treatment.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.