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Study · Randomized controlled trial · 2022

5 results

Adult attachment style moderates the effect of oxytocin on neural responses to infant emotional faces.

Ma Y, Liu G, Hu Y, Long W

International journal of psychophysiology : official journal of the International Organization of Psychophysiology14 Dec 2021Cited by 3 (Europe PMC)

PMID34919983 (opens in a new tab)DOI10.1016/j.ijpsycho.2021.12.003 (opens in a new tab)PepBankPUB-34919983
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In nulliparous females with high attachment anxiety, intranasal oxytocin decreased right amygdala activity in response to infant joy faces.

    In plain wordsIn women with high attachment anxiety, oxytocin nasal spray lowered right amygdala activity when viewing joyful infant faces, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseRight amygdala activity to infant joy faces in high attachment anxiety
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    The results indicated that females with high levels of attachment anxiety exhibited decreased right amygdala activity in response to infant joy faces and decreased bilateral insula activity in response to infant crying faces following IN-OT.
    2 context sentences
    Summary · context
    Using a between-groups, double-blind, placebo-controlled design, 65 nulliparous females were randomly assigned to groups receiving a single dose of 24 IU oxytocin or a placebo via intranasal administration.
    Summary · context
    The neural responses of participants were assessed during a facial recognition task with joy, neutral, and crying infant faces.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In nulliparous females with high attachment anxiety, intranasal oxytocin decreased bilateral insula activity in response to infant crying faces.

    In plain wordsIn women with high attachment anxiety, oxytocin nasal spray lowered insula activity when viewing crying infant faces, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseBilateral insula activity to infant crying faces in high attachment anxiety
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    The results indicated that females with high levels of attachment anxiety exhibited decreased right amygdala activity in response to infant joy faces and decreased bilateral insula activity in response to infant crying faces following IN-OT.
    2 context sentences
    Summary · context
    Using a between-groups, double-blind, placebo-controlled design, 65 nulliparous females were randomly assigned to groups receiving a single dose of 24 IU oxytocin or a placebo via intranasal administration.
    Summary · context
    The neural responses of participants were assessed during a facial recognition task with joy, neutral, and crying infant faces.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In nulliparous females with high attachment avoidance, intranasal oxytocin enhanced bilateral amygdala activity in response to infant crying faces.

    In plain wordsIn women with high attachment avoidance, oxytocin nasal spray raised amygdala activity when viewing crying infant faces, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseBilateral amygdala activity to infant crying faces in high attachment avoidance
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    Meanwhile, IN-OT enhanced bilateral amygdala and left inferior orbital frontal cortex (OFC) activity in response to infant crying faces in females with high levels of attachment avoidance.
    2 context sentences
    Summary · context
    Using a between-groups, double-blind, placebo-controlled design, 65 nulliparous females were randomly assigned to groups receiving a single dose of 24 IU oxytocin or a placebo via intranasal administration.
    Summary · context
    The neural responses of participants were assessed during a facial recognition task with joy, neutral, and crying infant faces.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In nulliparous females with high attachment avoidance, intranasal oxytocin enhanced left inferior orbital frontal cortex activity in response to infant crying faces.

    In plain wordsIn women with high attachment avoidance, oxytocin nasal spray raised left frontal cortex activity when viewing crying infant faces, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseLeft inferior orbital frontal cortex activity to infant crying faces in high attachment avoidance
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    Meanwhile, IN-OT enhanced bilateral amygdala and left inferior orbital frontal cortex (OFC) activity in response to infant crying faces in females with high levels of attachment avoidance.
    2 context sentences
    Summary · context
    Using a between-groups, double-blind, placebo-controlled design, 65 nulliparous females were randomly assigned to groups receiving a single dose of 24 IU oxytocin or a placebo via intranasal administration.
    Summary · context
    The neural responses of participants were assessed during a facial recognition task with joy, neutral, and crying infant faces.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In nulliparous females with low attachment avoidance or anxiety, some beneficial effects of intranasal oxytocin on neural responses were observed.

    In plain wordsIn women with low attachment avoidance or anxiety, oxytocin nasal spray showed some beneficial effects on brain responses, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    MixedNeural responses in low attachment avoidance or anxiety
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    In addition, some beneficial effects of IN-OT were also observed in females with low levels of attachment avoidance or anxiety.
    2 context sentences
    Summary · context
    Using a between-groups, double-blind, placebo-controlled design, 65 nulliparous females were randomly assigned to groups receiving a single dose of 24 IU oxytocin or a placebo via intranasal administration.
    Summary · context
    The neural responses of participants were assessed during a facial recognition task with joy, neutral, and crying infant faces.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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