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Study · Animal study (in vivo) · 2021

4 results

Targeting senescence-like fibroblasts radiosensitizes non-small cell lung cancer and reduces radiation-induced pulmonary fibrosis.

Meng J, Li Y, Wan C, Sun Y, Dai X, Huang J, Hu Y, Gao Y, Wu B, Zhang Z, Jiang K, Xu S and 5 more

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Lovell JF, Hu Y, Wu G, Jin H, Yang K

JCI insight8 Dec 2021Cited by 112 (Europe PMC)

PMID34877934 (opens in a new tab)PMCIDPMC8675198 (opens in a new tab)DOI10.1172/jci.insight.146334 (opens in a new tab)PepBankPUB-34877934
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Summary

Cancer cell radioresistance is the primary cause of the decreased curability of non-small cell lung cancer (NSCLC) observed in patients receiving definitive radiotherapy (RT). Following RT, a set of microenvironmental stress responses is triggered, including cell senescence. However, cell senescence is often ignored in designing effective strategies to resolve cancer cell radioresistance. Herein, we identify the senescence-like characteristics of cancer-associated fibroblasts (CAFs) after RT and clarify the formidable ability of senescence-like CAFs in promoting NSCLC cell proliferation and radioresistance through the JAK/STAT pathway. Specific induction of senescence-like CAF apoptosis using FOXO4-DRI, a FOXO4-p53-interfering peptide, resulted in remarkable effects on radiosensitizing NSCLC cells in vitro and in vivo. In addition, in this study, we also uncovered an obvious therapeutic effect of FOXO4-DRI on alleviating radiation-induced pulmonary fibrosis (RIPF) by targeting senescence-like fibroblasts in vivo. In conclusion, by targeting senescence, we offer a strategy that simultaneously decreases radioresistance of NSCLC and the incidence of RIPF.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In vivo, FOXO4‑DRI induced apoptosis of senescence-like CAFs and radiosensitized non-small cell lung cancer.

    In plain wordsIn animals, FOXO4‑DRI made lung cancer more sensitive to radiation.

    Peptide
    FOXO4-DRI
    Outcome
    IncreaseRadiosensitivity of NSCLC in vivo
    Study

    n: not reported in source

    In vivo NSCLC model
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Specific induction of senescence-like CAF apoptosis using FOXO4-DRI, a FOXO4-p53-interfering peptide, resulted in remarkable effects on radiosensitizing NSCLC cells in vitro and in vivo.
    1 context sentence
    Summary · context
    Herein, we identify the senescence-like characteristics of cancer-associated fibroblasts (CAFs) after RT and clarify the formidable ability of senescence-like CAFs in promoting NSCLC cell proliferation and radioresistance through the JAK/STAT pathway.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In vivo, FOXO4‑DRI had a therapeutic effect that alleviated radiation-induced pulmonary fibrosis by targeting senescence-like fibroblasts.

    In plain wordsIn animals, FOXO4‑DRI eased lung scarring caused by radiation.

    Peptide
    FOXO4-DRI
    Outcome
    DecreaseRadiation-induced pulmonary fibrosis
    Study

    n: not reported in source

    Radiation-induced pulmonary fibrosis in vivo
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, in this study, we also uncovered an obvious therapeutic effect of FOXO4-DRI on alleviating radiation-induced pulmonary fibrosis (RIPF) by targeting senescence-like fibroblasts in vivo.
  3. 03LabIn vitro (cells)Efficacy outcome

    FOXO4‑DRI specifically induced apoptosis of senescence-like cancer-associated fibroblasts after radiotherapy.

    In plain wordsIn cells, FOXO4‑DRI caused aged cancer-supporting fibroblasts to die.

    Peptide
    FOXO4-DRI
    Outcome
    IncreaseApoptosis of senescence-like CAFs
    Study

    n: not reported in source

    Senescence-like cancer-associated fibroblasts after radiotherapy
    Outcome group
    Cell viability and death · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Specific induction of senescence-like CAF apoptosis
  4. 04LabIn vitro (cells)Efficacy outcome

    In vitro, FOXO4‑DRI induced apoptosis of senescence-like CAFs and radiosensitized non-small cell lung cancer cells.

    In plain wordsIn cells, FOXO4‑DRI made lung cancer cells more sensitive to radiation.

    Peptide
    FOXO4-DRI
    Outcome
    IncreaseRadiosensitivity of NSCLC cells in vitro
    Study

    n: not reported in source

    NSCLC cells with senescence-like CAFs
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Specific induction of senescence-like CAF apoptosis using FOXO4-DRI, a FOXO4-p53-interfering peptide, resulted in remarkable effects on radiosensitizing NSCLC cells in vitro and in vivo.
    1 context sentence
    Summary · context
    Herein, we identify the senescence-like characteristics of cancer-associated fibroblasts (CAFs) after RT and clarify the formidable ability of senescence-like CAFs in promoting NSCLC cell proliferation and radioresistance through the JAK/STAT pathway.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

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