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Study · Animal study (in vivo) · mouse · 2022

4 results

Novel ADNP Syndrome Mice Reveal Dramatic Sex-Specific Peripheral Gene Expression With Brain Synaptic and Tau Pathologies.

Karmon G, Sragovich S, Hacohen-Kleiman G, Ben-Horin-Hazak I, Kasparek P, Schuster B, Sedlacek R, Pasmanik-Chor M, Theotokis P, Touloumi O, Zoidou S, Huang L and 13 more

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Wu PY, Shi R, Kapitansky O, Lobyntseva A, Giladi E, Shapira G, Shomron N, Bereswill S, Heimesaat MM, Grigoriadis N, McKinney RA, Rubinstein M, Gozes I

Biological psychiatry28 Sept 2021Cited by 58 (Europe PMC)

PMID34865853 (opens in a new tab)DOI10.1016/j.biopsych.2021.09.018 (opens in a new tab)PepBankPUB-34865853
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In Tyr mice, NAP corrected sex-specific spleen transcriptomic differences, including female antigen-processing and cellular-senescence effects.

    In plain wordsIn mice, NAP corrected sex-specific differences in spleen gene activity.

    Peptide
    Davunetide
    Outcome
    Direction not reportedSex-specific spleen gene expression
    Study

    mousen: not reported in source

    Adnp p.Tyr718* mice
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    RNA sequencing of spleens, representing a peripheral biomarker source, revealed Tyr-specific sex differences (e.g., cell cycle), accentuated in females (with significant effects on antigen processing and cellular senescence) and corrected by NAP.
    2 context sentences
    Summary · context
    Mimicking humans, CRISPR (clustered regularly interspaced short palindromic repeats)-Cas9 editing produced mice carrying heterozygous Adnp p.Tyr718∗ (Tyr), a paralog of the most common ADNP syndrome mutation.
    Summary · context
    Phenotypic rescue was validated by treatment with the microtubule/autophagy-protective ADNP fragment NAPVSIPQ (NAP).
  2. 02AnimalAnimal study (in vivo)Mechanism

    In Tyr mice, NAP ameliorated decreased dendritic spine density, with replication in Adnp+/- mice.

    In plain wordsIn mice, NAP improved reduced dendritic spine density.

    Peptide
    Davunetide
    Outcome
    IncreaseDendritic spine density
    Study

    mousen: not reported in source

    Adnp p.Tyr718* and Adnp+/- mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Anatomically, dendritic spine densities/morphologies were decreased with NAP amelioration.
    3 context sentences
    Summary · context
    These findings were replicated in the Adnp+/- mouse, including Foxo3 deregulation, required for dendritic spine formation.
    Summary · context
    Mimicking humans, CRISPR (clustered regularly interspaced short palindromic repeats)-Cas9 editing produced mice carrying heterozygous Adnp p.Tyr718∗ (Tyr), a paralog of the most common ADNP syndrome mutation.
    Summary · context
    Phenotypic rescue was validated by treatment with the microtubule/autophagy-protective ADNP fragment NAPVSIPQ (NAP).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In Tyr mice, NAP ameliorated abnormal dendritic spine morphology, with replication in Adnp+/- mice.

    In plain wordsIn mice, NAP improved abnormal dendritic spine morphology.

    Peptide
    Davunetide
    Outcome
    Direction not reportedDendritic spine morphology
    Study

    mousen: not reported in source

    Adnp p.Tyr718* and Adnp+/- mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Anatomically, dendritic spine densities/morphologies were decreased with NAP amelioration.
    3 context sentences
    Summary · context
    These findings were replicated in the Adnp+/- mouse, including Foxo3 deregulation, required for dendritic spine formation.
    Summary · context
    Mimicking humans, CRISPR (clustered regularly interspaced short palindromic repeats)-Cas9 editing produced mice carrying heterozygous Adnp p.Tyr718∗ (Tyr), a paralog of the most common ADNP syndrome mutation.
    Summary · context
    Phenotypic rescue was validated by treatment with the microtubule/autophagy-protective ADNP fragment NAPVSIPQ (NAP).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In Tyr mice, acute NAP treatment corrected impaired visual evoked potentials associated with early-onset tauopathy.

    In plain wordsIn mice, acute NAP treatment corrected impaired electrical responses to visual stimulation.

    Peptide
    Davunetide
    Outcome
    Direction not reportedVisual evoked potentials
    Study

    mousen: not reported in source

    Adnp p.Tyr718* mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Early-onset tauopathy was accentuated in males (hippocampus and visual cortex), mimicking humans, and was paralleled by impaired visual evoked potentials and correction by acute NAP treatment.
    2 context sentences
    Summary · context
    Mimicking humans, CRISPR (clustered regularly interspaced short palindromic repeats)-Cas9 editing produced mice carrying heterozygous Adnp p.Tyr718∗ (Tyr), a paralog of the most common ADNP syndrome mutation.
    Summary · context
    Phenotypic rescue was validated by treatment with the microtubule/autophagy-protective ADNP fragment NAPVSIPQ (NAP).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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