In situ mucoadhesive hydrogel capturing tripeptide KPV: the anti-inflammatory, antibacterial and repairing effect on chemotherapy-induced oral mucositis.

Shao W, Chen R, Lin G, Ran K, Zhang Y, Yang J, Pan H, Shangguan J, Zhao Y, Xu H

Biomaterials science21 Dec 2021Cited by 33 (Europe PMC)

PMID34846053DOI10.1039/d1bm01466hPepBankPUB-34846053

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study13

2 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Activity measurement
In cell tests, the anti-inflammatory activity of KPV was well maintained when KPV was loaded in the PPP-2% E hydrogel.
In plain wordsIn cells, KPV kept its anti-inflammatory activity when it was placed in the hydrogel.
Peptide
KPV
Outcome
Not applicableAnti-inflammatory activity of KPV in hydrogel
Study
n: not reported in source
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
The anti-inflammatory activity and promotion of cell migration potential by KPV in PPP-2% E hydrogel were well maintained.
1 context sentence(design, population, supporting numbers)
Summary · context
Tripeptide KPV as a model drug was easily dissolved in cold PPP_2%E precursor solution to prepare KPV@PPP_2%E hydrogel.
Report a problemFND-3484605301
02LabIn vitro (cells)Activity measurement
In cell tests, the potential of KPV to promote cell migration was well maintained when KPV was loaded in the PPP-2% E hydrogel.
In plain wordsIn cells, KPV kept its ability to promote cell migration when it was placed in the hydrogel.
Peptide
KPV
Outcome
Not applicableCell migration promotion by KPV in hydrogel
Study
n: not reported in source
Outcome group
Wound healing · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
The anti-inflammatory activity and promotion of cell migration potential by KPV in PPP-2% E hydrogel were well maintained.
1 context sentence(design, population, supporting numbers)
Summary · context
Tripeptide KPV as a model drug was easily dissolved in cold PPP_2%E precursor solution to prepare KPV@PPP_2%E hydrogel.
Report a problemFND-3484605302

Studies that did not test the peptide alone11

In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking KPV.

03AnimalNot a test of KPV aloneAnimal study (in vivo)Efficacy outcome
In rats with chemotherapy-induced oral mucositis, treatment with KPV@PPP_2%E hydrogel greatly improved food intake.
In plain wordsIn rats with oral mucositis, the KPV hydrogel improved food intake.
Peptide
KPV
Outcome
IncreaseFood intake recovery
Study
ratn: not reported in source
chemotherapy-induced oral mucositis
Outcome group
Appetite and food intake · Metabolic and weight
Source sentences
Summary
Treatment with KPV@PPP_2%E hydrogel greatly improved the food intake and body weight recovery of rats with chemotherapy-induced oral mucositis.
1 context sentence(design, population, supporting numbers)
Summary · context
Tripeptide KPV as a model drug was easily dissolved in cold PPP_2%E precursor solution to prepare KPV@PPP_2%E hydrogel.
In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.
Report a problemFND-3484605304
04AnimalNot a test of KPV aloneAnimal study (in vivo)Efficacy outcome
In rats with chemotherapy-induced oral mucositis, treatment with KPV@PPP_2%E hydrogel greatly improved body weight recovery.
In plain wordsIn rats with oral mucositis, the KPV hydrogel improved body weight recovery.
Peptide
KPV
Outcome
IncreaseBody weight recovery
Study
ratn: not reported in source
chemotherapy-induced oral mucositis
Outcome group
Body weight · Metabolic and weight
Source sentences
Summary
Treatment with KPV@PPP_2%E hydrogel greatly improved the food intake and body weight recovery of rats with chemotherapy-induced oral mucositis.
1 context sentence(design, population, supporting numbers)
Summary · context
Tripeptide KPV as a model drug was easily dissolved in cold PPP_2%E precursor solution to prepare KPV@PPP_2%E hydrogel.
In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.
Report a problemFND-3484605305
05AnimalNot a test of KPV aloneAnimal study (in vivo)Efficacy outcome
In rats with oral mucositis, the tissue morphology of the ulcerated gingiva was well repaired after application of KPV@PPP_E hydrogel.
In plain wordsIn rats with oral mucositis, the KPV hydrogel helped repair the ulcerated gum tissue.
Peptide
KPV
Outcome
Not applicableTissue morphology repair of ulcerated gingiva
Study
ratn: not reported in source
chemotherapy-induced oral mucositis
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
Moreover, the tissue morphology of the ulcerated gingiva after application of KPV@PPP_E hydrogel was also well repaired by promoting CK10 and PCNA expression.
1 context sentence(design, population, supporting numbers)
Summary · context
Tripeptide KPV as a model drug was easily dissolved in cold PPP_2%E precursor solution to prepare KPV@PPP_2%E hydrogel.
In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.
Report a problemFND-3484605306
06AnimalNot a test of KPV aloneAnimal study (in vivo)Mechanism
In rats with oral mucositis, KPV@PPP_E hydrogel repaired the ulcerated gingiva by promoting CK10 expression.
In plain wordsIn rats with oral mucositis, the KPV hydrogel raised CK10 expression in the damaged gum tissue.
Peptide
KPV
Outcome
IncreaseCK10 expression
Study
ratn: not reported in source
chemotherapy-induced oral mucositis
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
Moreover, the tissue morphology of the ulcerated gingiva after application of KPV@PPP_E hydrogel was also well repaired by promoting CK10 and PCNA expression.
1 context sentence(design, population, supporting numbers)
Summary · context
Tripeptide KPV as a model drug was easily dissolved in cold PPP_2%E precursor solution to prepare KPV@PPP_2%E hydrogel.
In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.
Report a problemFND-3484605307
07AnimalNot a test of KPV aloneAnimal study (in vivo)Mechanism
In rats with oral mucositis, KPV@PPP_E hydrogel repaired the ulcerated gingiva by promoting PCNA expression.
In plain wordsIn rats with oral mucositis, the KPV hydrogel raised PCNA expression in the damaged gum tissue.
Peptide
KPV
Outcome
IncreasePCNA expression
Study
ratn: not reported in source
chemotherapy-induced oral mucositis
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
Moreover, the tissue morphology of the ulcerated gingiva after application of KPV@PPP_E hydrogel was also well repaired by promoting CK10 and PCNA expression.
1 context sentence(design, population, supporting numbers)
Summary · context
Tripeptide KPV as a model drug was easily dissolved in cold PPP_2%E precursor solution to prepare KPV@PPP_2%E hydrogel.
In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.
Report a problemFND-3484605308
08AnimalNot a test of KPV aloneAnimal study (in vivo)Efficacy outcome
In rats with oral mucositis, KPV@PPP_2%E hydrogel significantly inhibited the inflammatory cytokine IL-1β.
In plain wordsIn rats with oral mucositis, the KPV hydrogel lowered the inflammatory signal IL-1β.
Peptide
KPV
Outcome
DecreaseIL-1β level
Study
ratn: not reported in source
chemotherapy-induced oral mucositis
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
In addition, the inflammatory cytokines including IL-1β and TNF-α were significantly inhibited by KPV@PPP_2%E hydrogel while IL-10 was up-regulated.
1 context sentence(design, population, supporting numbers)
Summary · context
Tripeptide KPV as a model drug was easily dissolved in cold PPP_2%E precursor solution to prepare KPV@PPP_2%E hydrogel.
In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.
Report a problemFND-3484605309
09AnimalNot a test of KPV aloneAnimal study (in vivo)Efficacy outcome
In rats with oral mucositis, KPV@PPP_2%E hydrogel significantly inhibited the inflammatory cytokine TNF-α.
In plain wordsIn rats with oral mucositis, the KPV hydrogel lowered the inflammatory signal TNF-α.
Peptide
KPV
Outcome
DecreaseTNF-α level
Study
ratn: not reported in source
chemotherapy-induced oral mucositis
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
In addition, the inflammatory cytokines including IL-1β and TNF-α were significantly inhibited by KPV@PPP_2%E hydrogel while IL-10 was up-regulated.
1 context sentence(design, population, supporting numbers)
Summary · context
Tripeptide KPV as a model drug was easily dissolved in cold PPP_2%E precursor solution to prepare KPV@PPP_2%E hydrogel.
In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.
Report a problemFND-3484605310
10AnimalNot a test of KPV aloneAnimal study (in vivo)Efficacy outcome
In rats with oral mucositis, KPV@PPP_2%E hydrogel up-regulated the anti-inflammatory cytokine IL-10.
In plain wordsIn rats with oral mucositis, the KPV hydrogel raised the anti-inflammatory signal IL-10.
Peptide
KPV
Outcome
IncreaseIL-10 level
Study
ratn: not reported in source
chemotherapy-induced oral mucositis
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
In addition, the inflammatory cytokines including IL-1β and TNF-α were significantly inhibited by KPV@PPP_2%E hydrogel while IL-10 was up-regulated.
1 context sentence(design, population, supporting numbers)
Summary · context
Tripeptide KPV as a model drug was easily dissolved in cold PPP_2%E precursor solution to prepare KPV@PPP_2%E hydrogel.
In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.
Report a problemFND-3484605311
11AnimalNot a test of KPV aloneAnimal study (in vivo)Efficacy outcome
In rats with MRSA-infected gingival ulcer wounds, the KPV@PPP_2%E hydrogel (which also contains EGCG, an antibacterial agent) had an anti-bacterial effect.
In plain wordsIn rats with MRSA-infected gum ulcers, the KPV hydrogel, which also contains an antibacterial agent (EGCG), had an antibacterial effect.
Peptide
KPV
Outcome
Not applicableAnti-bacterial effect in MRSA-infected gingival ulcer wounds
Study
ratn: not reported in source
MRSA-infected gingival ulcer wound
Outcome group
Infection and antimicrobial activity · Infection
Source sentences
Summary
KPV@PPP_2%E hydrogel also had an anti-bacterial effect on MRSA-infected gingival ulcer wounds, which resulted in the obvious inhibition of infiltration by inflammatory cells into submucosal tissues.
1 context sentence(design, population, supporting numbers)
Summary · context
Tripeptide KPV as a model drug was easily dissolved in cold PPP_2%E precursor solution to prepare KPV@PPP_2%E hydrogel.
In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.
Report a problemFND-3484605312
12AnimalNot a test of KPV aloneAnimal study (in vivo)Efficacy outcome
In rats with MRSA-infected gingival ulcers, KPV@PPP_2%E hydrogel obviously inhibited infiltration of inflammatory cells into submucosal tissues.
In plain wordsIn rats with MRSA-infected gum ulcers, the KPV hydrogel reduced the entry of inflammatory cells into deeper tissue.
Peptide
KPV
Outcome
DecreaseInflammatory cell infiltration into submucosal tissues
Study
ratn: not reported in source
MRSA-infected gingival ulcer wound
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
KPV@PPP_2%E hydrogel also had an anti-bacterial effect on MRSA-infected gingival ulcer wounds, which resulted in the obvious inhibition of infiltration by inflammatory cells into submucosal tissues.
1 context sentence(design, population, supporting numbers)
Summary · context
Tripeptide KPV as a model drug was easily dissolved in cold PPP_2%E precursor solution to prepare KPV@PPP_2%E hydrogel.
In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.
Report a problemFND-3484605313
13LabNot a test of KPV aloneIn vitro (cells)Activity measurement
In lab tests, the KPV@PPP_2%E hydrogel (which also contains EGCG, an antibacterial agent) showed strong antibacterial efficacy against S. aureus.
In plain wordsIn lab tests, the KPV hydrogel, which also contains an antibacterial agent (EGCG), strongly acted against S. aureus bacteria.
Peptide
KPV
Outcome
Not applicableAntibacterial efficacy against S. aureus
Study
S. aureusn: not reported in source
Outcome group
Infection and antimicrobial activity · Infection
Source sentences
Summary
Moreover, KPV@PPP_2%E exhibited strong antibacterial efficacy against S. aureus.
1 context sentence(design, population, supporting numbers)
Summary · context
Tripeptide KPV as a model drug was easily dissolved in cold PPP_2%E precursor solution to prepare KPV@PPP_2%E hydrogel.
In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.
Report a problemFND-3484605303

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:56 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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