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Study · Animal study (in vivo) · mouse · 2021

5 results

Activation of PTH1R alleviates epididymitis and orchitis through Gq and β-arrestin-1 pathways.

Wang MW, Yang Z, Chen X, Zhou SH, Huang GL, Sun JN, Jiang H, Xu WM, Lin HC, Yu X, Sun JP

Proceedings of the National Academy of Sciences of the United States of America1 Nov 2021Cited by 25 (Europe PMC)

PMID34740971 (opens in a new tab)PMCIDPMC8609314 (opens in a new tab)DOI10.1073/pnas.2107363118 (opens in a new tab)PepBankPUB-34740971
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, abaloparatide alleviated MuV- or LPS-induced inflammatory responses in the testis and epididymis.

    In plain wordsIn mice, abaloparatide reduced MuV- or LPS-induced inflammation in the testis and epididymis.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    DecreaseTesticular and epididymal inflammation
    Study

    mousen: not reported in source

    MuV- or LPS-induced reproductive inflammation
    Outcome group
    Inflammation markers · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Remarkably, activation of PTH1R by abaloparatide (ABL), a Food and Drug Administration-approved treatment for postmenopausal osteoporosis, alleviated MuV- or LPS-induced inflammatory responses in both testis and epididymis and significantly improved sperm functions in both mouse model and human samples.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with reproductive inflammation, abaloparatide significantly improved sperm functions.

    In plain wordsIn mice with reproductive inflammation, abaloparatide improved sperm functions.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseSperm functions
    Study

    mousen: not reported in source

    MuV- or LPS-induced reproductive inflammation
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Remarkably, activation of PTH1R by abaloparatide (ABL), a Food and Drug Administration-approved treatment for postmenopausal osteoporosis, alleviated MuV- or LPS-induced inflammatory responses in both testis and epididymis and significantly improved sperm functions in both mouse model and human samples.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mouse models, abaloparatide's anti-inflammatory effects were mainly regulated through Gq and β-arrestin-1 downstream of PTH1R.

    In plain wordsIn mice, Gq and β-arrestin-1 pathways mainly regulated abaloparatide's anti-inflammatory effects.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    Not applicableGq and β-arrestin-1 mediation
    Study

    mousen: not reported in source

    Gnaq heterozygous and Arrb1 knockout mouse models
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The anti-inflammatory effects of ABL were shown to be regulated mainly through the Gq and β-arrestin-1 pathway downstream of PTH1R as supported by the application of ABL in Gnaq± and Arrb1-/- mouse models.
  4. 04LabEx vivo tissueEfficacy outcome

    In human samples, abaloparatide alleviated MuV- or LPS-induced inflammatory responses in the testis and epididymis.

    In plain wordsIn lab tests with human samples, abaloparatide reduced MuV- or LPS-induced inflammatory responses in the testis and epididymis.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    DecreaseTesticular and epididymal inflammatory responses
    Study

    humann: not reported in source

    Human reproductive samples
    Outcome group
    Inflammation markers · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Remarkably, activation of PTH1R by abaloparatide (ABL), a Food and Drug Administration-approved treatment for postmenopausal osteoporosis, alleviated MuV- or LPS-induced inflammatory responses in both testis and epididymis and significantly improved sperm functions in both mouse model and human samples.
  5. 05LabEx vivo tissueEfficacy outcome

    In human samples, abaloparatide significantly improved sperm functions.

    In plain wordsIn lab tests with human samples, abaloparatide improved sperm functions.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseSperm functions
    Study

    humann: not reported in source

    Human samples
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Remarkably, activation of PTH1R by abaloparatide (ABL), a Food and Drug Administration-approved treatment for postmenopausal osteoporosis, alleviated MuV- or LPS-induced inflammatory responses in both testis and epididymis and significantly improved sperm functions in both mouse model and human samples.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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