The MOTS-c K14Q polymorphism in the mtDNA is associated with muscle fiber composition and muscular performance.

Kumagai H, Natsume T, Kim SJ, Tobina T, Miyamoto-Mikami E, Shiose K, Ichinoseki-Sekine N, Kakigi R, Tsuzuki T, Miller B, Yen K, Murakami H and 8 more

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Miyachi M, Zempo H, Dobashi S, Machida S, Kobayashi H, Naito H, Cohen P, Fuku N

Biochimica et biophysica acta. General subjects30 Oct 2021Cited by 16 (Europe PMC)

PMID34728329PMCIDPMC8741734DOI10.1016/j.bbagen.2021.130048PepBankPUB-34728329

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, MOTS-c was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MOTS-c.

01HumanNot a test of MOTS-c aloneObservational studyOther
In 211 healthy Japanese adults, carriers of the C allele of m.1382A>C (MOTS‑c K14Q) had a higher proportion of fast-twitch MHC-IIx fibers than A allele carriers.
In plain wordsIn healthy Japanese adults, people with the MOTS‑c K14Q gene variant had more fast-twitch muscle fibers than people without it.
Peptide
MOTS-c
Outcome
IncreaseProportion of MHC-IIx fibers by m.1382A>C genotype
Study
n = 211
Comparator
A allele carriers
Outcome group
Exercise and physical function · Musculoskeletal
Source sentences
Summary
Individuals with the C allele of the m.1382A>C exhibited a higher proportion of MHC-IIx, an index of fast-twitched fiber, than the A allele carriers.
2 context sentences(design, population, supporting numbers)
Summary · context
Within the MOTS-c open reading frame, there is an East Asian-specific m.1382A>C polymorphism (rs111033358) that changes the 14th amino acid of MOTS-c (i.e., K14Q), a variant of MOTS-c that has less biological activity.
Summary · context
The myosin heavy chain (MHC) isoforms (MHC-I, MHC-IIa, and MHC-IIx) as an indicator of muscle fiber composition were assessed in 211 Japanese healthy individuals (102 men and 109 women).
In this study, MOTS-c was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MOTS-c.
Report a problemFND-3472832901
02HumanNot a test of MOTS-c aloneObservational studyOther
In physically active young Japanese men, C allele carriers of m.1382A>C (MOTS‑c K14Q) had higher peak torques of leg flexion and extension.
In plain wordsIn active young Japanese men, those with the MOTS‑c K14Q gene variant had stronger leg muscles in a strength test.
Peptide
MOTS-c
Outcome
IncreasePeak torque of leg flexion and extension by genotype
Study
n = 86
Comparator
A allele carriers
Outcome group
Exercise and physical function · Musculoskeletal
Source sentences
Summary
Men with the C allele of m.1382A>C exhibited significantly higher peak torques of leg flexion and extension.
2 context sentences(design, population, supporting numbers)
Summary · context
Within the MOTS-c open reading frame, there is an East Asian-specific m.1382A>C polymorphism (rs111033358) that changes the 14th amino acid of MOTS-c (i.e., K14Q), a variant of MOTS-c that has less biological activity.
Summary · context
Muscular strength was measured in 86 physically active young Japanese men by using an isokinetic dynamometer.
In this study, MOTS-c was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MOTS-c.
Report a problemFND-3472832902
03HumanNot a test of MOTS-c aloneObservational studyOther
The C allele frequency of m.1382A>C (MOTS‑c K14Q) was highest in sprint/power athletes, then controls, then endurance athletes.
In plain wordsThe MOTS‑c K14Q gene variant was most common in sprint and power athletes and least common in endurance athletes.
Peptide
MOTS-c
Outcome
MixedC allele frequency in sprint/power athletes, controls and endurance athletes
Study
n: not reported in source
Outcome group
Exercise and physical function · Musculoskeletal
Measurements
C allele frequency
6.5%
sprint/power athletes
C allele frequency
5.1%
controls
C allele frequency
2.9%
endurance athletes
Source sentences
Summary
Furthermore, the C allele frequency was higher in the order of sprint/power athletes (6.5%), controls (5.1%), and endurance athletes (2.9%).
2 context sentences(design, population, supporting numbers)
Summary · context
Within the MOTS-c open reading frame, there is an East Asian-specific m.1382A>C polymorphism (rs111033358) that changes the 14th amino acid of MOTS-c (i.e., K14Q), a variant of MOTS-c that has less biological activity.
Summary · context
The allele frequency of the m.1382A>C polymorphism was assessed in 721 Japanese athletes and 873 ethnicity-matched controls.
In this study, MOTS-c was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MOTS-c.
Report a problemFND-3472832903
04AnimalNot a test of MOTS-c aloneAnimal study (in vivo)Mechanism
In young male mice, a MOTS‑c neutralizing antibody given weekly for four weeks increased expression of fast-twitch MHC compared with control mice.
In plain wordsIn mice, blocking MOTS‑c with an antibody increased fast-twitch muscle protein compared with control mice.
Peptide
MOTS-c
Outcome
IncreaseMHC-fast expression after MOTS-c neutralizing antibody
Study
mousen: not reported in source
Young male mice
Comparator
Control mice
Outcome group
Exercise and physical function · Musculoskeletal
Source sentences
Summary
Mice injected with MOTS-c neutralizing antibody showed a higher expression of MHC-fast than the control mice.
1 context sentence(design, population, supporting numbers)
Summary · context
Additionally, young male mice were injected with the MOTS-c neutralizing antibody once a week for four weeks to mimic the C allele of the m.1382A>C and assessed for protein expression levels of MHC-fast and MHC-slow.
In this study, MOTS-c was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MOTS-c.
Report a problemFND-3472832904

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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