Superior antioxidant and anti-ischemic neuroprotective effects of cerebrolysin in heat stroke following intoxication of engineered metal Ag and Cu nanoparticles: A comparative biochemical and physiological study with other stroke therapies.

Sharma HS, Muresanu DF, Ozkizilcik A, Sahib S, Tian ZR, Lafuente JV, Castellani RJ, Nozari A, Feng L, Buzoianu AD, Menon PK, Patnaik R, Wiklund L, Sharma A

Progress in brain research6 Oct 2021Cited by 8 (Europe PMC)

PMID34689862DOI10.1016/bs.pbr.2021.06.014PepBankPUB-34689862

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

10 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In heat-stressed rats, Cerebrolysin pretreatment reduced oxidative stress.
In plain wordsIn heat-stressed rats, Cerebrolysin pretreatment reduced oxidative stress.
Peptide
Cerebrolysin
Outcome
DecreaseOxidative stress
Study
ratsn: not reported in source
Heat stress
Outcome group
Oxidative stress · Nervous system and cognition
Studied dose
2.5mL/kg once daily · i.v. · 3 daysAs given in this study (rats).
Source sentences
Summary
Pretreatment with cerebrolysin (2.5mL/kg, i.v.) once daily for 3 days significantly attenuated the oxidative stress, BBB breakdown and brain edema and improved CBF in the heat stressed group.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats were subjected to 4h heat stress (HS) in a biological oxygen demand incubator at 38°C
Report a problemFND-3468986201
02AnimalAnimal study (in vivo)Efficacy outcome
In heat-stressed rats, Cerebrolysin pretreatment reduced blood-brain barrier breakdown.
In plain wordsIn heat-stressed rats, Cerebrolysin pretreatment reduced blood-brain barrier breakdown.
Peptide
Cerebrolysin
Outcome
DecreaseBlood-brain barrier breakdown
Study
ratsn: not reported in source
Heat stress
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
2.5mL/kg once daily · i.v. · 3 daysAs given in this study (rats).
Source sentences
Summary
Pretreatment with cerebrolysin (2.5mL/kg, i.v.) once daily for 3 days significantly attenuated the oxidative stress, BBB breakdown and brain edema and improved CBF in the heat stressed group.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats were subjected to 4h heat stress (HS) in a biological oxygen demand incubator at 38°C
Report a problemFND-3468986202
03AnimalAnimal study (in vivo)Efficacy outcome
In heat-stressed rats, Cerebrolysin pretreatment reduced brain edema.
In plain wordsIn heat-stressed rats, Cerebrolysin pretreatment reduced brain edema.
Peptide
Cerebrolysin
Outcome
DecreaseBrain edema
Study
ratsn: not reported in source
Heat stress
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
2.5mL/kg once daily · i.v. · 3 daysAs given in this study (rats).
Source sentences
Summary
Pretreatment with cerebrolysin (2.5mL/kg, i.v.) once daily for 3 days significantly attenuated the oxidative stress, BBB breakdown and brain edema and improved CBF in the heat stressed group.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats were subjected to 4h heat stress (HS) in a biological oxygen demand incubator at 38°C
Report a problemFND-3468986203
04AnimalAnimal study (in vivo)Efficacy outcome
In heat-stressed rats, Cerebrolysin pretreatment improved cerebral blood flow.
In plain wordsIn heat-stressed rats, Cerebrolysin pretreatment improved cerebral blood flow.
Peptide
Cerebrolysin
Outcome
IncreaseCerebral blood flow
Study
ratsn: not reported in source
Heat stress
Outcome group
Vascular function · Nervous system and cognition
Studied dose
2.5mL/kg once daily · i.v. · 3 daysAs given in this study (rats).
Source sentences
Summary
Pretreatment with cerebrolysin (2.5mL/kg, i.v.) once daily for 3 days significantly attenuated the oxidative stress, BBB breakdown and brain edema and improved CBF in the heat stressed group.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats were subjected to 4h heat stress (HS) in a biological oxygen demand incubator at 38°C
Report a problemFND-3468986204
05AnimalAnimal study (in vivo)Efficacy outcome
In nanoparticle-treated heat-stressed rats, conventional Cerebrolysin reduced oxidative stress.
In plain wordsIn nanoparticle-treated heat-stressed rats, conventional Cerebrolysin reduced oxidative stress.
Peptide
Cerebrolysin
Outcome
DecreaseOxidative stress with nanoparticles
Study
ratsn: not reported in source
Nanoparticle intoxication and heat stress
Outcome group
Oxidative stress · Nervous system and cognition
Studied dose
5mL/kg conventional · i.v.As given in this study (rats).
Source sentences
Summary
However, in NPs treated heat stressed animals 5mL/kg conventional cerebrolysin and 2.5mL/kg nanowired cerebrolysin is needed to attenuate oxidative stress, BBB breakdown, brain edema and to improve CBF.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats were subjected to 4h heat stress (HS) in a biological oxygen demand incubator at 38°C
Report a problemFND-3468986205
06AnimalAnimal study (in vivo)Efficacy outcome
In nanoparticle-treated heat-stressed rats, conventional Cerebrolysin reduced blood-brain barrier breakdown.
In plain wordsIn nanoparticle-treated heat-stressed rats, conventional Cerebrolysin reduced blood-brain barrier breakdown.
Peptide
Cerebrolysin
Outcome
DecreaseBlood-brain barrier breakdown with nanoparticles
Study
ratsn: not reported in source
Nanoparticle intoxication and heat stress
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5mL/kg conventional · i.v.As given in this study (rats).
Source sentences
Summary
However, in NPs treated heat stressed animals 5mL/kg conventional cerebrolysin and 2.5mL/kg nanowired cerebrolysin is needed to attenuate oxidative stress, BBB breakdown, brain edema and to improve CBF.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats were subjected to 4h heat stress (HS) in a biological oxygen demand incubator at 38°C
Report a problemFND-3468986206
07AnimalAnimal study (in vivo)Efficacy outcome
In nanoparticle-treated heat-stressed rats, conventional Cerebrolysin reduced brain edema.
In plain wordsIn nanoparticle-treated heat-stressed rats, conventional Cerebrolysin reduced brain edema.
Peptide
Cerebrolysin
Outcome
DecreaseBrain edema with nanoparticles
Study
ratsn: not reported in source
Nanoparticle intoxication and heat stress
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5mL/kg conventional · i.v.As given in this study (rats).
Source sentences
Summary
However, in NPs treated heat stressed animals 5mL/kg conventional cerebrolysin and 2.5mL/kg nanowired cerebrolysin is needed to attenuate oxidative stress, BBB breakdown, brain edema and to improve CBF.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats were subjected to 4h heat stress (HS) in a biological oxygen demand incubator at 38°C
Report a problemFND-3468986207
08AnimalAnimal study (in vivo)Efficacy outcome
In nanoparticle-treated heat-stressed rats, conventional Cerebrolysin improved cerebral blood flow.
In plain wordsIn nanoparticle-treated heat-stressed rats, conventional Cerebrolysin improved cerebral blood flow.
Peptide
Cerebrolysin
Outcome
IncreaseCerebral blood flow with nanoparticles
Study
ratsn: not reported in source
Nanoparticle intoxication and heat stress
Outcome group
Vascular function · Nervous system and cognition
Studied dose
5mL/kg conventional · i.v.As given in this study (rats).
Source sentences
Summary
However, in NPs treated heat stressed animals 5mL/kg conventional cerebrolysin and 2.5mL/kg nanowired cerebrolysin is needed to attenuate oxidative stress, BBB breakdown, brain edema and to improve CBF.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats were subjected to 4h heat stress (HS) in a biological oxygen demand incubator at 38°C
Report a problemFND-3468986208
09AnimalAnimal study (in vivo)Efficacy outcome
In heat-stressed rats, Cerebrolysin attenuated brain pathology more effectively than the other tested stroke therapies.
In plain wordsIn heat-stressed rats, Cerebrolysin reduced brain pathology more effectively than the other tested stroke therapies.
Peptide
Cerebrolysin
Outcome
DecreaseBrain pathology versus other stroke therapies
Study
ratsn: not reported in source
Heat stress
Comparator
Levertiracetam, pregabalin, topiramat and valproate
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
2.5mL/kg · i.v. · 3 daysAs given in this study (rats).
Source sentences
Summary
The other drugs were least effective on brain pathology following heat stroke.
3 context sentences(design, population, supporting numbers)
Summary · context
Pretreatment with cerebrolysin (2.5mL/kg, i.v.) once daily for 3 days significantly attenuated the oxidative stress, BBB breakdown and brain edema and improved CBF in the heat stressed group.
Summary · context
Thus, levertiracetam, pregabalin, topiramat and valproate were compared in standard doses with cerebrolysin in heat stroke intoxicated with Cu or Ag NPs (50-60nm, 50mg/kg, i.p./day for 7 days).
Summary · context
Rats were subjected to 4h heat stress (HS) in a biological oxygen demand incubator at 38°C
Report a problemFND-3468986213
10AnimalAnimal study (in vivo)Efficacy outcome
In nanoparticle-treated heat-stressed rats, conventional Cerebrolysin attenuated brain pathology, while the other tested drugs could not alter it.
In plain wordsIn nanoparticle-treated heat-stressed rats, conventional Cerebrolysin reduced brain pathology, while the other tested drugs could not alter it.
Peptide
Cerebrolysin
Outcome
DecreaseBrain pathology versus other therapies with nanoparticles
Study
ratsn: not reported in source
Nanoparticle intoxication and heat stress
Comparator
Levertiracetam, pregabalin, topiramat and valproate
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5mL/kg · i.v.As given in this study (rats).
Source sentences
Summary
However, in NPs treated heat stressed animals 5mL/kg conventional cerebrolysin and 2.5mL/kg nanowired cerebrolysin is needed to attenuate oxidative stress, BBB breakdown, brain edema and to improve CBF.
3 context sentences(design, population, supporting numbers)
Summary · context
Interestingly, the other drugs even in higher doses used are unable to alter brain pathologies in NPs and heat stress.
Summary · context
Thus, levertiracetam, pregabalin, topiramat and valproate were compared in standard doses with cerebrolysin in heat stroke intoxicated with Cu or Ag NPs (50-60nm, 50mg/kg, i.p./day for 7 days).
Summary · context
Rats were subjected to 4h heat stress (HS) in a biological oxygen demand incubator at 38°C
Report a problemFND-3468986214

Studies that did not test the peptide alone4

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

11AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In nanoparticle-treated heat-stressed rats, nanowired Cerebrolysin reduced oxidative stress.
In plain wordsIn nanoparticle-treated heat-stressed rats, nanowired Cerebrolysin reduced oxidative stress.
Peptide
Cerebrolysin
Outcome
DecreaseNanowired oxidative stress with nanoparticles
Study
ratsn: not reported in source
Nanoparticle intoxication and heat stress
Outcome group
Oxidative stress · Nervous system and cognition
Source sentences
Summary
However, in NPs treated heat stressed animals 5mL/kg conventional cerebrolysin and 2.5mL/kg nanowired cerebrolysin is needed to attenuate oxidative stress, BBB breakdown, brain edema and to improve CBF.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats were subjected to 4h heat stress (HS) in a biological oxygen demand incubator at 38°C
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3468986209
12AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In nanoparticle-treated heat-stressed rats, nanowired Cerebrolysin reduced blood-brain barrier breakdown.
In plain wordsIn nanoparticle-treated heat-stressed rats, nanowired Cerebrolysin reduced blood-brain barrier breakdown.
Peptide
Cerebrolysin
Outcome
DecreaseNanowired blood-brain barrier breakdown with nanoparticles
Study
ratsn: not reported in source
Nanoparticle intoxication and heat stress
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
However, in NPs treated heat stressed animals 5mL/kg conventional cerebrolysin and 2.5mL/kg nanowired cerebrolysin is needed to attenuate oxidative stress, BBB breakdown, brain edema and to improve CBF.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats were subjected to 4h heat stress (HS) in a biological oxygen demand incubator at 38°C
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3468986210
13AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In nanoparticle-treated heat-stressed rats, nanowired Cerebrolysin reduced brain edema.
In plain wordsIn nanoparticle-treated heat-stressed rats, nanowired Cerebrolysin reduced brain edema.
Peptide
Cerebrolysin
Outcome
DecreaseNanowired brain edema with nanoparticles
Study
ratsn: not reported in source
Nanoparticle intoxication and heat stress
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
However, in NPs treated heat stressed animals 5mL/kg conventional cerebrolysin and 2.5mL/kg nanowired cerebrolysin is needed to attenuate oxidative stress, BBB breakdown, brain edema and to improve CBF.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats were subjected to 4h heat stress (HS) in a biological oxygen demand incubator at 38°C
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3468986211
14AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In nanoparticle-treated heat-stressed rats, nanowired Cerebrolysin improved cerebral blood flow.
In plain wordsIn nanoparticle-treated heat-stressed rats, nanowired Cerebrolysin improved cerebral blood flow.
Peptide
Cerebrolysin
Outcome
IncreaseNanowired cerebral blood flow with nanoparticles
Study
ratsn: not reported in source
Nanoparticle intoxication and heat stress
Outcome group
Vascular function · Nervous system and cognition
Source sentences
Summary
However, in NPs treated heat stressed animals 5mL/kg conventional cerebrolysin and 2.5mL/kg nanowired cerebrolysin is needed to attenuate oxidative stress, BBB breakdown, brain edema and to improve CBF.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats were subjected to 4h heat stress (HS) in a biological oxygen demand incubator at 38°C
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3468986212

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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