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Study · Animal study (in vivo) · rat · 2021

3 results

Cerebrolysin restores balance between excitatory and inhibitory amino acids in brain following concussive head injury. Superior neuroprotective effects of TiO2 nanowired drug delivery.

Sharma HS, Muresanu DF, Sahib S, Tian ZR, Lafuente JV, Buzoianu AD, Castellani RJ, Nozari A, Li C, Zhang Z, Wiklund L, Sharma A

Progress in brain research6 Oct 2021Cited by 10 (Europe PMC)

PMID34689860 (opens in a new tab)DOI10.1016/bs.pbr.2021.06.016 (opens in a new tab)PepBankPUB-34689860
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with concussive head injury, repeated Cerebrolysin produced dose-dependent neuroprotection.

    In plain wordsIn rats with concussive head injury, repeated Cerebrolysin produced dose-dependent neuroprotection.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseNeuroprotection
    Study

    ratsn: not reported in source

    Concussive head injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    5-10mL/kg · i.v.As given in this study (rats).

    Source sentences

    Summary
    Our observations show that repeated CBL induced a dose-dependent neuroprotection in CHI (5-10mL/kg) and also improved behavioral functions.
    2 context sentences
    Summary · context
    CHI was produced in anesthetized rats by dropping a weight of 114.6g over the right exposed parietal skull from a distance of 20cm height (0.224N impact)
    Summary · context
    Cerebrolysin (CBL) was administered (2.5, 5 or 10mL/kg, i.v.) after 4-72h following injury.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with concussive head injury, repeated Cerebrolysin improved behavioral function.

    In plain wordsIn rats with concussive head injury, repeated Cerebrolysin improved behavioral function.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseBehavioral function
    Study

    ratsn: not reported in source

    Concussive head injury
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    5-10mL/kg · i.v.As given in this study (rats).

    Source sentences

    Summary
    Our observations show that repeated CBL induced a dose-dependent neuroprotection in CHI (5-10mL/kg) and also improved behavioral functions.
    2 context sentences
    Summary · context
    CHI was produced in anesthetized rats by dropping a weight of 114.6g over the right exposed parietal skull from a distance of 20cm height (0.224N impact)
    Summary · context
    Cerebrolysin (CBL) was administered (2.5, 5 or 10mL/kg, i.v.) after 4-72h following injury.

Studies that did not test the peptide alone1

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

  1. 03AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome

    In rats with concussive head injury, nanowired Cerebrolysin showed superior neuroprotection at lower doses than conventional delivery.

    In plain wordsIn rats with concussive head injury, nanowired Cerebrolysin showed better neuroprotection at lower doses than conventional delivery.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseNanowired neuroprotection
    Study

    ratsn: not reported in source

    Concussive head injury
    Comparator
    Conventional Cerebrolysin delivery
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Interestingly when CBL is delivered through TiO2 nanowires superior neuroprotective effects were observed in CHI even at a lower doses (2.5-5mL/kg).
    2 context sentences
    Summary · context
    CHI was produced in anesthetized rats by dropping a weight of 114.6g over the right exposed parietal skull from a distance of 20cm height (0.224N impact)
    Summary · context
    Cerebrolysin (CBL) was administered (2.5, 5 or 10mL/kg, i.v.) after 4-72h following injury.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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