Changes in MOTS-c Level in the Blood of Pregnant Women with Metabolic Disorders.

Wojciechowska M, Pruszyńska-Oszmałek E, Kołodziejski PA, Krauss H, Leciejewska N, Szczepankiewicz D, Bień J, Skrzypski M, Wilczak M, Sassek M

Biology12 Oct 2021Cited by 10 (Europe PMC)

PMID34681131PMCIDPMC8533113DOI10.3390/biology10101032PepBankPUB-34681131

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Summary

MOTS-c peptide is a member of the group of mitochondria-derived peptides (MDP). It is a product of the open reading frame in the 12S RNA gene. Due to its features and functions in the body, this peptide is classified as a hormone. The first publications indicated that this hormone improves insulin sensitivity and lowers body weight in obese animals. This suggests that it may be an important peptide in maintaining the body's energy homeostasis. The aim of our work was to investigate the potential role of MOTS-c peptide during pregnancy, which is a condition prone to metabolic disorders. The research covered healthy, obese women and women with thyroid disorders. The obtained results indicated an increase in the concentration of MOTS-c in the blood of mothers and newborns in the obese group as compared to the healthy control group and a corresponding decrease in the concentration of this peptide in mothers and newborns in the group with hypothyroidism compared to the obese group. Moreover, we also observed a strong positive correlation between the concentration of MOTS-c in maternal blood and in umbilical cord blood. In summary, the MOTS-c peptide shows changes in blood concentration in various physiological states and may, in the future, become an important tool in the fight against metabolic diseases such as obesity or type 2 diabetes.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
In pregnant women, MOTS‑c concentration in maternal blood was higher in the obese group than in healthy controls.
In plain wordsIn pregnant women, the body's own MOTS‑c level in blood was higher with obesity than in healthy women.
Peptide
MOTS-c
Outcome
IncreaseMOTS-c in maternal blood, obese versus healthy
Study
n: not reported in source
Comparator
Healthy control group
Outcome group
Endogenous peptide levels · Metabolic and weight
Source sentences
Summary
increase in the concentration of MOTS-c in the blood of mothers and newborns in the obese group as compared to the healthy control group
1 context sentence(design, population, supporting numbers)
Summary · context
The research covered healthy, obese women and women with thyroid disorders.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Show in the study text Report a problemFND-3468113101
02HumanEndogenous levelObservational studyOther
MOTS‑c concentration in the blood of newborns was higher in the obese group than in the healthy control group.
In plain wordsThe body's own MOTS‑c level in newborns' blood was higher in the obese group than in the healthy group.
Peptide
MOTS-c
Outcome
IncreaseMOTS-c in newborn blood, obese versus healthy mothers
Study
n: not reported in source
Comparator
Healthy control group
Outcome group
Endogenous peptide levels · Metabolic and weight
Source sentences
Summary
increase in the concentration of MOTS-c in the blood of mothers and newborns in the obese group as compared to the healthy control group
1 context sentence(design, population, supporting numbers)
Summary · context
The research covered healthy, obese women and women with thyroid disorders.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Show in the study text Report a problemFND-3468113102
03HumanEndogenous levelObservational studyOther
MOTS‑c concentration in maternal blood was lower in women with hypothyroidism than in the obese group.
In plain wordsThe body's own MOTS‑c level in blood was lower in women with hypothyroidism than in obese women.
Peptide
MOTS-c
Outcome
DecreaseMOTS-c in maternal blood, hypothyroidism versus obese
Study
n: not reported in source
Comparator
Obese group
Outcome group
Endogenous peptide levels · Metabolic and weight
Source sentences
Summary
a corresponding decrease in the concentration of this peptide in mothers and newborns in the group with hypothyroidism compared to the obese group
1 context sentence(design, population, supporting numbers)
Summary · context
The research covered healthy, obese women and women with thyroid disorders.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Show in the study text Report a problemFND-3468113103
04HumanEndogenous levelObservational studyOther
MOTS‑c concentration in the blood of newborns was lower in the hypothyroidism group than in the obese group.
In plain wordsThe body's own MOTS‑c level in newborns' blood was lower in the hypothyroidism group than in the obese group.
Peptide
MOTS-c
Outcome
DecreaseMOTS-c in newborn blood, hypothyroidism versus obese
Study
n: not reported in source
Comparator
Obese group
Outcome group
Endogenous peptide levels · Metabolic and weight
Source sentences
Summary
a corresponding decrease in the concentration of this peptide in mothers and newborns in the group with hypothyroidism compared to the obese group
1 context sentence(design, population, supporting numbers)
Summary · context
The research covered healthy, obese women and women with thyroid disorders.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Show in the study text Report a problemFND-3468113104
05HumanEndogenous levelObservational studyOther
MOTS‑c concentration in maternal blood correlated strongly and positively with that in umbilical cord blood.
In plain wordsThe body's own MOTS‑c level in a mother's blood was closely linked to the level in her baby's cord blood.
Peptide
MOTS-c
Outcome
Not applicableCorrelation of MOTS-c between maternal and umbilical cord blood
Study
n: not reported in source
Outcome group
Endogenous peptide levels · Metabolic and weight
Source sentences
Summary
Moreover, we also observed a strong positive correlation between the concentration of MOTS-c in maternal blood and in umbilical cord blood.
1 context sentence(design, population, supporting numbers)
Summary · context
The research covered healthy, obese women and women with thyroid disorders.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Show in the study text Report a problemFND-3468113105

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

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