Protective effects of cerebrolysin against chemotherapy (carmustine) induced cognitive impairment in Albino mice.

Sharma S, Raj K, Singh S

Drug and chemical toxicology21 Oct 2021Cited by 5 (Europe PMC)

PMID34674598DOI10.1080/01480545.2021.1991195PepBankPUB-34674598

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In mice, Cerebrolysin improved cognitive functions dose-dependently compared with BCNU alone.
In plain wordsIn mice, Cerebrolysin improved thinking function compared with BCNU alone.
Peptide
Cerebrolysin
Outcome
IncreaseCognitive functions
Study
micen: not reported in source
Carmustine-induced cognitive deficits
Comparator
BCNU administered mice
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
44 and 88 mg/kg · i.p. · 28 daysAs given in this study (mice).
Source sentences
Summary
However, mice treated with CBN (44 and 88 mg/kg, i.p.) significantly and dose-dependently improved cognitive functions, reduced oxidative stress markers, inflammatory cytokines and restored neurotransmitters concentration as compared to BCNU administered mice (p < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
CBN (44 and 88 mg/kg, i.p.) was administered daily from day 1 to 28 to BCNU treatment mice.
Report a problemFND-3467459801
02AnimalAnimal study (in vivo)Efficacy outcome
In mice, Cerebrolysin reduced oxidative stress markers dose-dependently compared with BCNU alone.
In plain wordsIn mice, Cerebrolysin reduced oxidative stress markers compared with BCNU alone.
Peptide
Cerebrolysin
Outcome
DecreaseOxidative stress markers
Study
micen: not reported in source
Carmustine-induced cognitive deficits
Comparator
BCNU administered mice
Outcome group
Oxidative stress · Nervous system and cognition
Studied dose
44 and 88 mg/kg · i.p. · 28 daysAs given in this study (mice).
Source sentences
Summary
However, mice treated with CBN (44 and 88 mg/kg, i.p.) significantly and dose-dependently improved cognitive functions, reduced oxidative stress markers, inflammatory cytokines and restored neurotransmitters concentration as compared to BCNU administered mice (p < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
CBN (44 and 88 mg/kg, i.p.) was administered daily from day 1 to 28 to BCNU treatment mice.
Report a problemFND-3467459802
03AnimalAnimal study (in vivo)Efficacy outcome
In mice, Cerebrolysin reduced inflammatory cytokines dose-dependently compared with BCNU alone.
In plain wordsIn mice, Cerebrolysin reduced inflammatory cytokines compared with BCNU alone.
Peptide
Cerebrolysin
Outcome
DecreaseInflammatory cytokines
Study
micen: not reported in source
Carmustine-induced cognitive deficits
Comparator
BCNU administered mice
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
44 and 88 mg/kg · i.p. · 28 daysAs given in this study (mice).
Source sentences
Summary
However, mice treated with CBN (44 and 88 mg/kg, i.p.) significantly and dose-dependently improved cognitive functions, reduced oxidative stress markers, inflammatory cytokines and restored neurotransmitters concentration as compared to BCNU administered mice (p < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
CBN (44 and 88 mg/kg, i.p.) was administered daily from day 1 to 28 to BCNU treatment mice.
Report a problemFND-3467459803
04AnimalAnimal study (in vivo)Efficacy outcome
In mice, Cerebrolysin restored neurotransmitter concentration compared with BCNU alone.
In plain wordsIn mice, Cerebrolysin restored neurotransmitter concentration compared with BCNU alone.
Peptide
Cerebrolysin
Outcome
Direction not reportedNeurotransmitter concentration
Study
micen: not reported in source
Carmustine-induced cognitive deficits
Comparator
BCNU administered mice
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
44 and 88 mg/kg · i.p. · 28 daysAs given in this study (mice).
Source sentences
Summary
However, mice treated with CBN (44 and 88 mg/kg, i.p.) significantly and dose-dependently improved cognitive functions, reduced oxidative stress markers, inflammatory cytokines and restored neurotransmitters concentration as compared to BCNU administered mice (p < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
CBN (44 and 88 mg/kg, i.p.) was administered daily from day 1 to 28 to BCNU treatment mice.
Report a problemFND-3467459804

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 ongoing · source ClinicalTrials.gov (opens in a new tab)

Enrolling by invitationNot applicableNCT06677502

Cerebrolysin in Critically Ill Patients With Delirium

Medical University of Lublinn = 5001 Jan 2024 to est. 31 Dec 2025

Cognitive Impairment

Trial page ClinicalTrials.govUpdated 31 Dec 2024

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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