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Study · Systematic review · 2021

2 results

The influence of oxytocin-based interventions on sleep-wake and sleep-related behaviour and neurobiology: A systematic review of preclinical and clinical studies.

Raymond JS, Rehn S, Hoyos CM, Bowen MT

Neuroscience and biobehavioral reviews18 Oct 2021Cited by 15 (Europe PMC)

PMID34673110 (opens in a new tab)DOI10.1016/j.neubiorev.2021.10.016 (opens in a new tab)PepBankPUB-34673110
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. 1 result from people.

  1. 01HumanSystematic reviewEfficacy outcome

    In clinical studies, oxytocin had little or no sleep-promoting influence.

    In plain wordsIn clinical studies in people, oxytocin showed little or no effect in promoting sleep.

    Peptide
    Oxytocin
    Outcome
    No significant changeSleep promotion by oxytocin (clinical)
    Study

    n: not reported in source

    Outcome group
    Sleep · Sleep
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the clinical evidence suggests little or no sleep-promoting influence of OXT.
    1 context sentence
    Summary · context
    The primary search was conducted on 22/7/2020 using six electronic databases; 30 studies (19 preclinical, 11 clinical) were included based on inclusion criteria.

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 02AnimalNot a test of Oxytocin aloneOther designEfficacy outcome

    In preclinical studies, activation of the oxytocin system was suggested to have a wake-promoting influence.

    In plain wordsIn animal studies, activating the body's oxytocin system appeared to promote wakefulness.

    Peptide
    Oxytocin
    Outcome
    IncreaseWakefulness with oxytocin system activation (preclinical)
    Study

    n: not reported in source

    Outcome group
    Sleep · Sleep

    Source sentences

    Summary
    Preclinical evidence suggests a wake-promoting influence of OXT system activation
    1 context sentence
    Summary · context
    The primary search was conducted on 22/7/2020 using six electronic databases; 30 studies (19 preclinical, 11 clinical) were included based on inclusion criteria.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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