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Study · Not a test of the peptide alone · 2021

4 results

Biomimetic Melanosomes Promote Orientation-Selective Delivery and Melanocyte Pigmentation in the H2O2-Induced Vitiligo Mouse Model.

Sun MC, Xu XL, Du Y, Lou XF, Wang W, You YC, Liu D, Jin FY, Qi J, Zhu MX, Zhu LW, Wang J, Du YZ

ACS nano18 Oct 2021Cited by 30 (Europe PMC)

PMID34662120 (opens in a new tab)DOI10.1021/acsnano.1c05321 (opens in a new tab)PepBankPUB-34662120
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking KPV.

  1. 01AnimalNot a test of KPV aloneAnimal study (in vivo)Pharmacokinetics

    KPV-modified deformable liposomes showed 1.43-fold greater skin deposition than traditional liposomes.

    In plain wordsKPV-tagged liposomes reached the skin 1.43 times more than ordinary liposomes.

    Peptide
    KPV
    Outcome
    IncreaseSkin deposition of KPV-modified liposomes
    Study

    mousen: not reported in source

    H2O2-induced vitiligo mouse model
    Comparator
    Traditional liposomes
    Outcome group
    Pharmacokinetics · Pharmacology

    Measurements

    Skin deposition vs traditional liposomes
    1.43 fold
    KPV-Lipos

    Source sentences

    Summary
    Owing to their phospholipid bilayer flexibility and the specific affinity for melanocortin 1 receptor (MC1R), KPV-Lipos exhibited 1.43-fold greater skin deposition than traditional liposomes.

    In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.

  2. 02AnimalNot a test of KPV aloneAnimal study (in vivo)Mechanism

    Binding of KPV to its receptor contributed to activating the cAMP-tyrosinase signaling pathway.

    In plain wordsThe tag KPV binding its receptor helped switch on a pigment-making signal.

    Peptide
    KPV
    Outcome
    IncreasecAMP-tyrosinase signaling pathway activation
    Study

    mousen: not reported in source

    H2O2-induced vitiligo mouse model
    Outcome group
    Receptor activity and mechanism · Skin and wound

    Source sentences

    Summary
    The binding of KPV and its receptor also contributed to activating the cAMP-tyrosinase (TYR) signaling pathway, improving the endogenous melanin content.

    In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.

  3. 03AnimalNot a test of KPV aloneAnimal study (in vivo)Efficacy outcome

    KPV-receptor binding and the resulting cAMP-TYR activation improved the endogenous melanin content.

    In plain wordsKPV binding its receptor was linked to more of the body's own melanin pigment.

    Peptide
    KPV
    Outcome
    IncreaseEndogenous melanin content
    Study

    mousen: not reported in source

    H2O2-induced vitiligo mouse model
    Outcome group
    Pigmentation · Skin and wound

    Source sentences

    Summary
    The binding of KPV and its receptor also contributed to activating the cAMP-tyrosinase (TYR) signaling pathway, improving the endogenous melanin content.

    In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.

  4. 04AnimalNot a test of KPV aloneAnimal study (in vivo)Efficacy outcome

    In mice with H2O2-induced vitiligo, the biomimetic melanosomes (KPV-modified liposomes with methylprednisolone and polydopamine) affected the skin color; the direction is not stated.

    In plain wordsIn mice with vitiligo, the KPV-tagged melanosome particles changed skin color.

    Peptide
    KPV
    Outcome
    Direction not reportedSkin color of mice with H2O2-induced vitiligo
    Study

    mousen: not reported in source

    H2O2-induced vitiligo mouse model
    Outcome group
    Pigmentation · Skin and wound

    Source sentences

    Summary
    Ultimately, the biomimetic melanosomes affected the skin color of mice with H2O2-induced vitiligo.

    In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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