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Study · In vitro (cells) · pseudomonas aeruginosa · 2021

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Chemical Synthesis of a Potent Antimicrobial Peptide Murepavadin Using a Tandem Native Chemical Ligation/Desulfurization Reaction.

Chaudhuri D, Ganesan R, Vogelaar A, Dughbaj MA, Beringer PM, Camarero JA

The Journal of organic chemistry12 Oct 2021Cited by 14 (Europe PMC)

PMID34641669 (opens in a new tab)PMCIDPMC8935662 (opens in a new tab)DOI10.1021/acs.joc.1c01858 (opens in a new tab)PepBankPUB-34641669
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In clinical Pseudomonas aeruginosa isolates, synthetic murepavadin showed potent antimicrobial activity.

    In plain wordsIn lab tests, synthetic murepavadin showed antimicrobial activity against clinical bacterial isolates.

    Peptide
    Murepavadin
    Outcome
    Direction not reportedAntimicrobial activity
    Study

    Pseudomonas aeruginosan: not reported in source

    Clinical isolates
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The synthetic peptide antibiotic showed potent activity against different clinical isolates of P. aeruginosa.
    1 context sentence
    Summary · context
    Here, we describe an efficient epimerization-free approach for the Fmoc-based synthesis of murepavadin using intramolecular native chemical ligation in combination with a concomitant desulfurization reaction.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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