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Study · Animal study (in vivo) · rat · 2021

3 results

The mitochondrial signaling peptide MOTS-c improves myocardial performance during exercise training in rats.

Yuan J, Wang M, Pan Y, Liang M, Fu Y, Duan Y, Tang M, Laher I, Li S

Scientific reports11 Oct 2021Cited by 27 (Europe PMC)

PMID34635713 (opens in a new tab)PMCIDPMC8505603 (opens in a new tab)DOI10.1038/s41598-021-99568-3 (opens in a new tab)PepBankPUB-34635713
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Summary

Cardiac remodeling is a physiological adaptation to aerobic exercise and which is characterized by increases in ventricular volume and the number of cardiomyocytes. The mitochondrial derived peptide MOTS-c functions as an important regulator in physical capacity and performance. Exercise elevates levels of endogenous MOTS-c in circulation and in myocardium, while MOTS-c can significantly enhance exercise capacity. However, the effects of aerobic exercise combined with MOTS-c on cardiac structure and function are unclear. We used pressure-volume conductance catheter technique to examine cardiac function in exercised rats with and without treatment with MOTS-c. Surprisingly, MOTS-c improved myocardial mechanical efficiency, enhanced cardiac systolic function, and had a tendency to improve the diastolic function. The findings suggest that using exercise supplements could be used to modulate the cardiovascular benefits of athletic training.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In exercised rats, MOTS‑c improved myocardial mechanical efficiency.

    In plain wordsIn exercised rats, MOTS‑c improved how efficiently the heart muscle works, compared with exercised rats without MOTS‑c.

    Peptide
    MOTS-c
    Outcome
    IncreaseMyocardial mechanical efficiency
    Study

    ratn: not reported in source

    Exercise-trained rats
    Comparator
    Exercised rats without MOTS-c
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Surprisingly, MOTS-c improved myocardial mechanical efficiency, enhanced cardiac systolic function, and had a tendency to improve the diastolic function.
    1 context sentence
    Summary · context
    We used pressure-volume conductance catheter technique to examine cardiac function in exercised rats with and without treatment with MOTS-c.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In exercised rats, MOTS‑c enhanced cardiac systolic function.

    In plain wordsIn exercised rats, MOTS‑c improved the heart's pumping function, compared with exercised rats without MOTS‑c.

    Peptide
    MOTS-c
    Outcome
    IncreaseCardiac systolic function
    Study

    ratn: not reported in source

    Exercise-trained rats
    Comparator
    Exercised rats without MOTS-c
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Surprisingly, MOTS-c improved myocardial mechanical efficiency, enhanced cardiac systolic function, and had a tendency to improve the diastolic function.
    1 context sentence
    Summary · context
    We used pressure-volume conductance catheter technique to examine cardiac function in exercised rats with and without treatment with MOTS-c.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In exercised rats, MOTS‑c had a tendency to improve diastolic function.

    In plain wordsIn exercised rats, MOTS‑c showed only a tendency to improve the heart's filling function, compared with exercised rats without MOTS‑c.

    Peptide
    MOTS-c
    Outcome
    No significant changeCardiac diastolic function
    Study

    ratn: not reported in source

    Exercise-trained rats
    Comparator
    Exercised rats without MOTS-c
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Surprisingly, MOTS-c improved myocardial mechanical efficiency, enhanced cardiac systolic function, and had a tendency to improve the diastolic function.
    1 context sentence
    Summary · context
    We used pressure-volume conductance catheter technique to examine cardiac function in exercised rats with and without treatment with MOTS-c.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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