Growth hormone secretagogue peptide-6 enhances oreochromicins transcription and antimicrobial activity in tilapia (Oreochromis sp.).

Hernández L, Camacho H, Nuñez-Robainas A, Palenzuela DO, Morales A, Basabe L, Herrera F, Rodrigo O, Rodriguez-Gabilondo A, Velázquez J, Piloto S, Estrada MP, Martínez R

Fish & shellfish immunology28 Sept 2021Cited by 5 (Europe PMC)

PMID34592474DOI10.1016/j.fsi.2021.08.011PepBankPUB-34592474

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In tilapia, GHRP‑6 increased Oreochromicin I transcription in a tissue-dependent manner.
In plain wordsIn tilapia, GHRP‑6 increased Oreochromicin I gene activity depending on the tissue.
Peptide
GHRP-6
Outcome
IncreaseOreochromicin I transcription
Study
tilapia (Oreochromis sp.)n: not reported in source
Tilapia with and without Pseudomonas aeruginosa infection
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
GHRP-6 up-regulated the transcription levels of three piscidin-like antimicrobial peptides (Oreochromicins I, II, and III) and granzyme in a tissue-dependent manner.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study focuses on the immunomodulatory effects of GHRP-6 in tilapia with and without the presence of Pseudomonas aeruginosa infection.
Report a problemFND-3459247401
02AnimalAnimal study (in vivo)Mechanism
In tilapia, GHRP‑6 increased Oreochromicin II transcription in a tissue-dependent manner.
In plain wordsIn tilapia, GHRP‑6 increased Oreochromicin II gene activity depending on the tissue.
Peptide
GHRP-6
Outcome
IncreaseOreochromicin II transcription
Study
tilapia (Oreochromis sp.)n: not reported in source
Tilapia with and without Pseudomonas aeruginosa infection
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
GHRP-6 up-regulated the transcription levels of three piscidin-like antimicrobial peptides (Oreochromicins I, II, and III) and granzyme in a tissue-dependent manner.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study focuses on the immunomodulatory effects of GHRP-6 in tilapia with and without the presence of Pseudomonas aeruginosa infection.
Report a problemFND-3459247402
03AnimalAnimal study (in vivo)Mechanism
In tilapia, GHRP‑6 increased Oreochromicin III transcription in a tissue-dependent manner.
In plain wordsIn tilapia, GHRP‑6 increased Oreochromicin III gene activity depending on the tissue.
Peptide
GHRP-6
Outcome
IncreaseOreochromicin III transcription
Study
tilapia (Oreochromis sp.)n: not reported in source
Tilapia with and without Pseudomonas aeruginosa infection
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
GHRP-6 up-regulated the transcription levels of three piscidin-like antimicrobial peptides (Oreochromicins I, II, and III) and granzyme in a tissue-dependent manner.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study focuses on the immunomodulatory effects of GHRP-6 in tilapia with and without the presence of Pseudomonas aeruginosa infection.
Report a problemFND-3459247403
04AnimalAnimal study (in vivo)Mechanism
In tilapia, GHRP‑6 increased granzyme transcription in a tissue-dependent manner.
In plain wordsIn tilapia, GHRP‑6 increased granzyme gene activity depending on the tissue.
Peptide
GHRP-6
Outcome
IncreaseGranzyme transcription
Study
tilapia (Oreochromis sp.)n: not reported in source
Tilapia with and without Pseudomonas aeruginosa infection
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
GHRP-6 up-regulated the transcription levels of three piscidin-like antimicrobial peptides (Oreochromicins I, II, and III) and granzyme in a tissue-dependent manner.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study focuses on the immunomodulatory effects of GHRP-6 in tilapia with and without the presence of Pseudomonas aeruginosa infection.
Report a problemFND-3459247404
05AnimalAnimal study (in vivo)Mechanism
In tilapia, GHRP‑6 stimulated serum lysozyme activity.
In plain wordsIn tilapia, GHRP‑6 increased serum lysozyme activity.
Peptide
GHRP-6
Outcome
IncreaseSerum lysozyme activity
Study
tilapia (Oreochromis sp.)n: not reported in source
Tilapia with and without Pseudomonas aeruginosa infection
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Antimicrobial activity stimulation in serum (lysozyme and anti-protease activity) was also confirmed.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study focuses on the immunomodulatory effects of GHRP-6 in tilapia with and without the presence of Pseudomonas aeruginosa infection.
Report a problemFND-3459247405
06AnimalAnimal study (in vivo)Mechanism
In tilapia, GHRP‑6 stimulated serum anti-protease activity.
In plain wordsIn tilapia, GHRP‑6 increased serum activity that inhibits protein-degrading enzymes.
Peptide
GHRP-6
Outcome
IncreaseSerum anti-protease activity
Study
tilapia (Oreochromis sp.)n: not reported in source
Tilapia with and without Pseudomonas aeruginosa infection
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Antimicrobial activity stimulation in serum (lysozyme and anti-protease activity) was also confirmed.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study focuses on the immunomodulatory effects of GHRP-6 in tilapia with and without the presence of Pseudomonas aeruginosa infection.
Report a problemFND-3459247406
07AnimalAnimal study (in vivo)Efficacy outcome
In tilapia infected with P. aeruginosa, GHRP‑6 decreased bacterial load in vivo.
In plain wordsIn tilapia infected with P. aeruginosa, GHRP‑6 reduced the bacterial load.
Peptide
GHRP-6
Outcome
DecreaseBacterial load after infection
Study
tilapia (Oreochromis sp.)n: not reported in source
Tilapia with and without Pseudomonas aeruginosa infection
Outcome group
Infection and antimicrobial activity · Infection
Studied dose
Dose not stated
Source sentences
Summary
Besides, GHRP-6 enhanced the in vitro antimicrobial activity against P. aeruginosa in tilapia gills mucus and serum samples and decreased the bacterial load in vivo after infection with this Gram-negative bacterium.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study focuses on the immunomodulatory effects of GHRP-6 in tilapia with and without the presence of Pseudomonas aeruginosa infection.
Report a problemFND-3459247409
08LabEx vivo tissueActivity measurement
In tilapia gill mucus samples, GHRP‑6 enhanced antimicrobial activity against P. aeruginosa in vitro.
In plain wordsIn lab tests with tilapia gill mucus, GHRP‑6 increased antimicrobial activity against P. aeruginosa.
Peptide
GHRP-6
Outcome
IncreaseGill mucus antimicrobial activity
Study
tilapia (Oreochromis sp.)n: not reported in source
Tilapia gill mucus samples tested against P. aeruginosa
Outcome group
Infection and antimicrobial activity · Infection
Studied dose
Dose not stated
Source sentences
Summary
Besides, GHRP-6 enhanced the in vitro antimicrobial activity against P. aeruginosa in tilapia gills mucus and serum samples
1 context sentence(design, population, supporting numbers)
Summary · context
The present study focuses on the immunomodulatory effects of GHRP-6 in tilapia with and without the presence of Pseudomonas aeruginosa infection.
Report a problemFND-3459247407
09LabEx vivo tissueActivity measurement
In tilapia serum samples, GHRP‑6 enhanced antimicrobial activity against P. aeruginosa in vitro.
In plain wordsIn lab tests with tilapia serum, GHRP‑6 increased antimicrobial activity against P. aeruginosa.
Peptide
GHRP-6
Outcome
IncreaseSerum antimicrobial activity
Study
tilapia (Oreochromis sp.)n: not reported in source
Tilapia serum samples tested against P. aeruginosa
Outcome group
Infection and antimicrobial activity · Infection
Studied dose
Dose not stated
Source sentences
Summary
Besides, GHRP-6 enhanced the in vitro antimicrobial activity against P. aeruginosa in tilapia gills mucus and serum samples
1 context sentence(design, population, supporting numbers)
Summary · context
The present study focuses on the immunomodulatory effects of GHRP-6 in tilapia with and without the presence of Pseudomonas aeruginosa infection.
Report a problemFND-3459247408

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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Journal Article

MeSH terms

Keywords

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