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Study · Randomized controlled trial · n = 61 · 2021

2 results

Oxytocin reduces romantic rejection-induced pain in online speed-dating as revealed by decreased frontal-midline theta oscillations.

Zhang X, Li P, Otieno SCSA, Li H, Leppänen PHT

Psychoneuroendocrinology10 Sept 2021Cited by 20 (Europe PMC)

PMID34537623 (opens in a new tab)DOI10.1016/j.psyneuen.2021.105411 (opens in a new tab)PepBankPUB-34537623
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy participants, oxytocin significantly decreased the frontal-midline theta power that romantic rejection induced, compared with placebo.

    In plain wordsIn healthy people, oxytocin lowered a brain signal linked to the pain of romantic rejection compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseFrontal-midline theta power induced by romantic rejection
    Study

    n = 61

    Comparator
    Placebo
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    romantic rejection induced significantly decreased theta power compared to the placebo group
    1 context sentence
    Summary · context
    Electroencephalographic recordings were obtained between August 2nd and October 20th, 2020 in Shenzhen University from 61 healthy participants in a double-blind, placebo-controlled study with a between-subject design.
  2. 02HumanRandomized controlled trialMechanism

    In healthy participants given oxytocin, there was no association between frontal-midline theta power and rejection distress, unlike in the placebo group.

    In plain wordsIn healthy people given oxytocin, the brain signal was not linked to rejection distress, unlike in the placebo group.

    Peptide
    Oxytocin
    Outcome
    No significant changeAssociation between theta power and rejection distress
    Study

    n = 61

    Comparator
    Placebo
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    in the OT group, there was no association between theta power and rejection distress.
    2 context sentences
    Summary · context
    In the placebo group, greater theta power was induced by romantic rejection, being associated with rejection distress.
    Summary · context
    Electroencephalographic recordings were obtained between August 2nd and October 20th, 2020 in Shenzhen University from 61 healthy participants in a double-blind, placebo-controlled study with a between-subject design.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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