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Study · Non-randomized trial · n = 96 · 2021

3 results

Tracking transient changes in the intrinsic neural frequency architecture: Oxytocin facilitates non-harmonic relationships between alpha and theta rhythms in the resting brain.

Alaerts K, Taillieu A, Prinsen J, Daniels N

Psychoneuroendocrinology27 Aug 2021Cited by 7 (Europe PMC)

PMID34481326 (opens in a new tab)DOI10.1016/j.psyneuen.2021.105397 (opens in a new tab)PepBankPUB-34481326
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanNon-randomized trialMechanism

    In healthy men, a single intranasal oxytocin dose significantly increased transient non-harmonic alpha-theta cross-frequency configurations at rest compared with placebo.

    In plain wordsIn healthy men, one dose of oxytocin nasal spray increased a resting brain-rhythm pattern compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseTransient non-harmonic alpha-theta cross-frequency configurations
    Study

    n = 96

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    The transient formation of non-harmonic cross-frequency configurations between alpha and theta peak frequencies was significantly increased after OT nasal spray administration, indicating an effect of OT on reducing the intrinsic occurrence of spurious (noisy) background phase synchronizations during resting-state.
    1 context sentence
    Summary · context
    To do so, continuous resting-state electroencephalography (5 min eyes open, 19 electrodes) was obtained from 96 healthy adult men before and after nasal spray administration.
  2. 02HumanNon-randomized trialMechanism

    In healthy men, the oxytocin group showed a significant increase in high-frequency heart rate variability after a single intranasal dose.

    In plain wordsIn healthy men, high-frequency heart rate variability rose in the group that got one dose of oxytocin nasal spray.

    Peptide
    Oxytocin
    Outcome
    IncreaseHigh-frequency heart rate variability
    Study

    n = 96

    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    the OT group also showed a significant parallel increase in high-frequency and decrease in low-frequency heart rate variability, confirming a homeostatic role of OT in balancing parasympathetic drive.
    1 context sentence
    Summary · context
    To do so, continuous resting-state electroencephalography (5 min eyes open, 19 electrodes) was obtained from 96 healthy adult men before and after nasal spray administration.
  3. 03HumanNon-randomized trialMechanism

    In healthy men, the oxytocin group showed a significant decrease in low-frequency heart rate variability after a single intranasal dose.

    In plain wordsIn healthy men, low-frequency heart rate variability fell in the group that got one dose of oxytocin nasal spray.

    Peptide
    Oxytocin
    Outcome
    DecreaseLow-frequency heart rate variability
    Study

    n = 96

    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    the OT group also showed a significant parallel increase in high-frequency and decrease in low-frequency heart rate variability, confirming a homeostatic role of OT in balancing parasympathetic drive.
    1 context sentence
    Summary · context
    To do so, continuous resting-state electroencephalography (5 min eyes open, 19 electrodes) was obtained from 96 healthy adult men before and after nasal spray administration.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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