Multifaceted roles of a bioengineered nanoreactor in repressing radiation-induced lung injury.

Liu T, Yang Q, Zheng H, Jia H, He Y, Zhang X, Zheng J, Xi Y, Zhang H, Sun R, Chen X, Shan W

Biomaterials27 Aug 2021Cited by 31 (Europe PMC)

PMID34478930DOI10.1016/j.biomaterials.2021.121103PepBankPUB-34478930

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone7

In this study, Cibinetide (ARA-290) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cibinetide (ARA-290).

01AnimalNot a test of Cibinetide (ARA-290) aloneAnimal study (in vivo)Efficacy outcome
In a mouse model of radiation-induced lung injury, intratracheal SOD@ARA290-HBc significantly ameliorated acute radiation pneumonitis.
In plain wordsIn mice with radiation lung injury, the SOD@ARA290-HBc nanoreactor reduced acute lung inflammation.
Peptide
Cibinetide (ARA-290)
Outcome
DecreaseAcute radiation pneumonitis
Study
mousen: not reported in source
Radiation-induced lung injury (RILI) mouse model
Outcome group
Lung injury and fibrosis · Respiratory
Source sentences
Summary
In a RILI mouse model, intratracheal administration of SOD@ARA290-HBc was shown to significantly ameliorate acute radiation pneumonitis and pulmonary fibrosis.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we describe a novel strategy to exert additive effects of a non-erythropoietic EPO derivative (ARA290), along with a free radical scavenger, superoxide dismutase (SOD), using a bioengineered nanoreactor (SOD@ARA290-HBc).
In this study, Cibinetide (ARA-290) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cibinetide (ARA-290).
Report a problemFND-3447893001
02AnimalNot a test of Cibinetide (ARA-290) aloneAnimal study (in vivo)Efficacy outcome
In a mouse model of radiation-induced lung injury, intratracheal SOD@ARA290-HBc significantly ameliorated pulmonary fibrosis.
In plain wordsIn mice with radiation lung injury, the SOD@ARA290-HBc nanoreactor reduced lung scarring.
Peptide
Cibinetide (ARA-290)
Outcome
DecreasePulmonary fibrosis
Study
mousen: not reported in source
Radiation-induced lung injury (RILI) mouse model
Outcome group
Lung injury and fibrosis · Respiratory
Source sentences
Summary
In a RILI mouse model, intratracheal administration of SOD@ARA290-HBc was shown to significantly ameliorate acute radiation pneumonitis and pulmonary fibrosis.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we describe a novel strategy to exert additive effects of a non-erythropoietic EPO derivative (ARA290), along with a free radical scavenger, superoxide dismutase (SOD), using a bioengineered nanoreactor (SOD@ARA290-HBc).
In this study, Cibinetide (ARA-290) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cibinetide (ARA-290).
Report a problemFND-3447893002
03AnimalNot a test of Cibinetide (ARA-290) aloneAnimal study (in vivo)Mechanism
SOD@ARA290-HBc protected against radiation-induced alveolar epithelial cell apoptosis in the RILI mouse model.
In plain wordsIn mice with radiation lung injury, the nanoreactor protected lung cells from radiation-induced cell death.
Peptide
Cibinetide (ARA-290)
Outcome
DecreaseAlveolar epithelial cell apoptosis
Study
mousen: not reported in source
Radiation-induced lung injury (RILI) mouse model
Outcome group
Receptor activity and mechanism · Respiratory
Source sentences
Summary
Our investigations revealed that SOD@ARA290-HBc performs its radioprotective effects by protecting against radiation induced alveolar epithelial cell apoptosis and ferroptosis, suppressing oxidative stress, inhibiting inflammation and by modulating the infiltrated macrophage phenotype, or through a…
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we describe a novel strategy to exert additive effects of a non-erythropoietic EPO derivative (ARA290), along with a free radical scavenger, superoxide dismutase (SOD), using a bioengineered nanoreactor (SOD@ARA290-HBc).
In this study, Cibinetide (ARA-290) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cibinetide (ARA-290).
Report a problemFND-3447893003
04AnimalNot a test of Cibinetide (ARA-290) aloneAnimal study (in vivo)Mechanism
SOD@ARA290-HBc protected against radiation-induced alveolar epithelial cell ferroptosis in the RILI mouse model.
In plain wordsIn mice with radiation lung injury, the nanoreactor protected lung cells from iron-related cell death.
Peptide
Cibinetide (ARA-290)
Outcome
DecreaseAlveolar epithelial cell ferroptosis
Study
mousen: not reported in source
Radiation-induced lung injury (RILI) mouse model
Outcome group
Receptor activity and mechanism · Respiratory
Source sentences
Summary
Our investigations revealed that SOD@ARA290-HBc performs its radioprotective effects by protecting against radiation induced alveolar epithelial cell apoptosis and ferroptosis, suppressing oxidative stress, inhibiting inflammation and by modulating the infiltrated macrophage phenotype, or through a…
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we describe a novel strategy to exert additive effects of a non-erythropoietic EPO derivative (ARA290), along with a free radical scavenger, superoxide dismutase (SOD), using a bioengineered nanoreactor (SOD@ARA290-HBc).
In this study, Cibinetide (ARA-290) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cibinetide (ARA-290).
Report a problemFND-3447893004
05AnimalNot a test of Cibinetide (ARA-290) aloneAnimal study (in vivo)Mechanism
SOD@ARA290-HBc suppressed oxidative stress in the RILI mouse model.
In plain wordsIn mice with radiation lung injury, the nanoreactor reduced oxidative stress.
Peptide
Cibinetide (ARA-290)
Outcome
DecreaseOxidative stress
Study
mousen: not reported in source
Radiation-induced lung injury (RILI) mouse model
Outcome group
Receptor activity and mechanism · Respiratory
Source sentences
Summary
Our investigations revealed that SOD@ARA290-HBc performs its radioprotective effects by protecting against radiation induced alveolar epithelial cell apoptosis and ferroptosis, suppressing oxidative stress, inhibiting inflammation and by modulating the infiltrated macrophage phenotype, or through a…
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we describe a novel strategy to exert additive effects of a non-erythropoietic EPO derivative (ARA290), along with a free radical scavenger, superoxide dismutase (SOD), using a bioengineered nanoreactor (SOD@ARA290-HBc).
In this study, Cibinetide (ARA-290) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cibinetide (ARA-290).
Report a problemFND-3447893005
06AnimalNot a test of Cibinetide (ARA-290) aloneAnimal study (in vivo)Mechanism
SOD@ARA290-HBc inhibited inflammation in the RILI mouse model.
In plain wordsIn mice with radiation lung injury, the nanoreactor reduced inflammation.
Peptide
Cibinetide (ARA-290)
Outcome
DecreaseLung inflammation
Study
mousen: not reported in source
Radiation-induced lung injury (RILI) mouse model
Outcome group
Inflammation markers · Respiratory
Source sentences
Summary
Our investigations revealed that SOD@ARA290-HBc performs its radioprotective effects by protecting against radiation induced alveolar epithelial cell apoptosis and ferroptosis, suppressing oxidative stress, inhibiting inflammation and by modulating the infiltrated macrophage phenotype, or through a…
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we describe a novel strategy to exert additive effects of a non-erythropoietic EPO derivative (ARA290), along with a free radical scavenger, superoxide dismutase (SOD), using a bioengineered nanoreactor (SOD@ARA290-HBc).
In this study, Cibinetide (ARA-290) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cibinetide (ARA-290).
Report a problemFND-3447893006
07AnimalNot a test of Cibinetide (ARA-290) aloneAnimal study (in vivo)Mechanism
SOD@ARA290-HBc modulated the phenotype of infiltrated macrophages in the RILI mouse model.
In plain wordsIn mice with radiation lung injury, the nanoreactor changed the type of immune cells that entered the lung.
Peptide
Cibinetide (ARA-290)
Outcome
Not applicableInfiltrated macrophage phenotype
Study
mousen: not reported in source
Radiation-induced lung injury (RILI) mouse model
Outcome group
Immune response · Respiratory
Source sentences
Summary
Our investigations revealed that SOD@ARA290-HBc performs its radioprotective effects by protecting against radiation induced alveolar epithelial cell apoptosis and ferroptosis, suppressing oxidative stress, inhibiting inflammation and by modulating the infiltrated macrophage phenotype, or through a…
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we describe a novel strategy to exert additive effects of a non-erythropoietic EPO derivative (ARA290), along with a free radical scavenger, superoxide dismutase (SOD), using a bioengineered nanoreactor (SOD@ARA290-HBc).
In this study, Cibinetide (ARA-290) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cibinetide (ARA-290).
Report a problemFND-3447893007

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 19:08 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

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