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Study · Not a test of the peptide alone · 2021

4 results

Comparison of external calibration and isotope dilution LC-ICP-MS/MS for quantitation of oxytocin and its selenium analogue in human plasma.

Grønbæk-Thorsen F, Jensen C, Østergaard J, Møller LH, Gammelgaard B

Analytical and bioanalytical chemistry30 Aug 2021Cited by 1 (Europe PMC)

PMID34458946 (opens in a new tab)DOI10.1007/s00216-021-03611-1 (opens in a new tab)PepBankPUB-34458946
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01LabNot a test of Oxytocin aloneIn vitro (cell-free)Other

    A gradient-elution LC-ICP-MS/MS method quantified oxytocin and its diselenide analogue in human plasma, and external calibration and isotope dilution were both fit for purpose.

    In plain wordsIn lab tests, a new method measured oxytocin and a selenium version of it in human plasma, and two calibration methods both worked.

    Peptide
    Oxytocin
    Outcome
    Not applicableLC-ICP-MS/MS quantitation of oxytocin and selenium analogue in plasma
    Study

    humann: not reported in source

    human plasma
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    In the present study, a method for quantitation of the pharmaceutical peptide oxytocin (OT) and its diselenide-containing analogue (SeOT) in human plasma was developed using gradient elution LC-ICP-MS/MS.
    1 context sentence
    Summary · context
    Both calibration methods appeared to be fit for purpose regarding figures of merit including linearity, precision, LOD, LOQ and recovery.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02LabNot a test of Oxytocin aloneIn vitro (cell-free)Other

    Selenium-based analysis of oxytocin and its selenium analogue was considerably more sensitive and selective than sulfur-based analysis.

    In plain wordsIn lab tests, measuring the selenium atom was more sensitive and selective than measuring the sulfur atom in oxytocin.

    Peptide
    Oxytocin
    Outcome
    Not applicableSensitivity of selenium-based versus sulfur-based analysis
    Study

    humann: not reported in source

    human plasma
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    Analysis of OT and SeOT showed that selenium-based analysis is considerably more sensitive and selective compared to the sulfur-based analysis.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 03LabNot a test of Oxytocin aloneIn vitro (cell-free)Other

    In a stability study in human plasma, oxytocin and its selenium analogue degraded over time.

    In plain wordsIn lab tests, oxytocin and a selenium version of it broke down in human plasma.

    Peptide
    Oxytocin
    Outcome
    Not applicableDegradation of oxytocin in plasma
    Study

    humann: not reported in source

    human plasma
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    The method was applied for a stability study showing the degradation of OT and SeOT in plasma.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  4. 04LabNot a test of Oxytocin aloneIn vitro (cell-free)Other

    In human plasma, the diselenide analogue of oxytocin degraded faster than oxytocin.

    In plain wordsIn lab tests, the selenium version of oxytocin broke down faster in human plasma than natural oxytocin did.

    Peptide
    Oxytocin
    Outcome
    Not applicableDegradation rate of selenium analogue versus oxytocin in plasma
    Study

    humann: not reported in source

    human plasma
    Comparator
    Oxytocin
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    The degradation of SeOT was faster than the degradation of OT in plasma.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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