Plasma mitochondrial derived peptides MOTS-c and SHLP2 positively associate with android and liver fat in people without diabetes.

Sequeira IR, Woodhead JST, Chan A, D'Souza RF, Wan J, Hollingsworth KG, Plank LD, Cohen P, Poppitt SD, Merry TL

Biochimica et biophysica acta. General subjects20 Aug 2021Cited by 20 (Europe PMC)

PMID34419510DOI10.1016/j.bbagen.2021.129991PepBankPUB-34419510

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

No result from this study comes from a test of the peptide.

Natural levels measured9

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
In Chinese adults without overt type 2 diabetes, plasma MOTS‑c levels were elevated in those with metabolic syndrome.
In plain wordsIn Chinese adults, the body's own MOTS‑c level in blood was higher in people with metabolic syndrome.
Peptide
MOTS-c
Outcome
IncreasePlasma MOTS-c in metabolic syndrome
Study
n = 125
Outcome group
Endogenous peptide levels · Metabolic and weight
Source sentences
Summary
plasma MOTS-c (315 ± 27 pg/ml) and SHLP2 (1393 ± 82 pg/ml) were elevated in those with MS (n = 26)
1 context sentence(design, population, supporting numbers)
Summary · context
One-hundred and twenty-five Chinese participants (91 male, 34 female) had anthropometry, whole body dual-energy X-ray absorptiometry scans and fasted blood samples analysed.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3441951001
02HumanEndogenous levelObservational studyOther
Plasma MOTS‑c was positively associated with waist circumference (p < 0.0001), the most significant metabolic syndrome component.
In plain wordsThe body's own MOTS‑c level in blood was linked to a larger waist, the strongest link of the components checked.
Peptide
MOTS-c
Outcome
IncreaseAssociation of plasma MOTS-c with waist circumference
Study
n = 125
Outcome group
Body composition · Metabolic and weight
Source sentences
Summary
While multiple components of the MS sequelae positively associated with both MOTS-c and SHLP2, including blood pressure, fasting plasma glucose and triglycerides, the most significant of these was waist circumference (p < 0.0001).
1 context sentence(design, population, supporting numbers)
Summary · context
One-hundred and twenty-five Chinese participants (91 male, 34 female) had anthropometry, whole body dual-energy X-ray absorptiometry scans and fasted blood samples analysed.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3441951002
03HumanEndogenous levelObservational studyOther
Plasma MOTS‑c was positively associated with blood pressure.
In plain wordsThe body's own MOTS‑c level in blood was linked to higher blood pressure.
Peptide
MOTS-c
Outcome
IncreaseAssociation of plasma MOTS-c with blood pressure
Study
n = 125
Outcome group
Blood pressure · Metabolic and weight
Source sentences
Summary
While multiple components of the MS sequelae positively associated with both MOTS-c and SHLP2, including blood pressure, fasting plasma glucose and triglycerides, the most significant of these was waist circumference (p < 0.0001).
1 context sentence(design, population, supporting numbers)
Summary · context
One-hundred and twenty-five Chinese participants (91 male, 34 female) had anthropometry, whole body dual-energy X-ray absorptiometry scans and fasted blood samples analysed.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3441951003
04HumanEndogenous levelObservational studyOther
Plasma MOTS‑c was positively associated with fasting plasma glucose.
In plain wordsThe body's own MOTS‑c level in blood was linked to higher fasting blood sugar.
Peptide
MOTS-c
Outcome
IncreaseAssociation of plasma MOTS-c with fasting plasma glucose
Study
n = 125
Outcome group
Glycemic control · Metabolic and weight
Source sentences
Summary
While multiple components of the MS sequelae positively associated with both MOTS-c and SHLP2, including blood pressure, fasting plasma glucose and triglycerides, the most significant of these was waist circumference (p < 0.0001).
1 context sentence(design, population, supporting numbers)
Summary · context
One-hundred and twenty-five Chinese participants (91 male, 34 female) had anthropometry, whole body dual-energy X-ray absorptiometry scans and fasted blood samples analysed.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3441951004
05HumanEndogenous levelObservational studyOther
Plasma MOTS‑c was positively associated with triglycerides.
In plain wordsThe body's own MOTS‑c level in blood was linked to higher triglycerides.
Peptide
MOTS-c
Outcome
IncreaseAssociation of plasma MOTS-c with triglycerides
Study
n = 125
Outcome group
Lipids · Metabolic and weight
Source sentences
Summary
While multiple components of the MS sequelae positively associated with both MOTS-c and SHLP2, including blood pressure, fasting plasma glucose and triglycerides, the most significant of these was waist circumference (p < 0.0001).
1 context sentence(design, population, supporting numbers)
Summary · context
One-hundred and twenty-five Chinese participants (91 male, 34 female) had anthropometry, whole body dual-energy X-ray absorptiometry scans and fasted blood samples analysed.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3441951005
06HumanEndogenous levelObservational studyOther
Android fat had a greater effect on increasing plasma MOTS‑c (p < 0.004) than whole body fat.
In plain wordsThe body's own MOTS‑c level in blood rose more with fat around the abdomen than with total body fat.
Peptide
MOTS-c
Outcome
IncreaseEffect of android fat on plasma MOTS-c
Study
n = 125
Outcome group
Body composition · Metabolic and weight
Source sentences
Summary
Android fat had a greater effect on increasing plasma MOTS-c (p < 0.004)
1 context sentence(design, population, supporting numbers)
Summary · context
One-hundred and twenty-five Chinese participants (91 male, 34 female) had anthropometry, whole body dual-energy X-ray absorptiometry scans and fasted blood samples analysed.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3441951006
07HumanEndogenous levelObservational studyOther
After correction for total body fat mass, liver fat measured by MRI/S was positively associated with plasma MOTS‑c.
In plain wordsThe body's own MOTS‑c level in blood was linked to more liver fat, independent of total body fat.
Peptide
MOTS-c
Outcome
IncreaseAssociation of plasma MOTS-c with liver fat
Study
n: not reported in source
Outcome group
Liver fat and liver function · Liver
Source sentences
Summary
liver fat positively associated with plasma MOTS-c and SHLP2
2 context sentences(design, population, supporting numbers)
Summary · context
Chinese female participants and an additional 34 European Caucasian female participants also underwent magnetic resonance imaging and spectroscopy (MRI/S) for visceral, pancreatic and liver fat quantification.
Summary · context
One-hundred and twenty-five Chinese participants (91 male, 34 female) had anthropometry, whole body dual-energy X-ray absorptiometry scans and fasted blood samples analysed.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3441951007
08HumanEndogenous levelObservational studyOther
Plasma MOTS‑c was higher in participants with elevated liver damage markers.
In plain wordsThe body's own MOTS‑c level in blood was higher in people with raised liver damage markers.
Peptide
MOTS-c
Outcome
IncreasePlasma MOTS-c with elevated liver damage markers
Study
n: not reported in source
Outcome group
Liver fat and liver function · Liver
Source sentences
Summary
plasma MOTS-c and SHLP2 were higher in participants with elevated liver damage markers
1 context sentence(design, population, supporting numbers)
Summary · context
One-hundred and twenty-five Chinese participants (91 male, 34 female) had anthropometry, whole body dual-energy X-ray absorptiometry scans and fasted blood samples analysed.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3441951008
09AnimalEndogenous levelAnimal study (in vivo)Other
Plasma MOTS‑c was higher in male C57Bl/6j mice fed a diet that induces hepatic lipid accumulation and damage.
In plain wordsIn mice on a liver-damaging diet, the body's own MOTS‑c level in blood was higher.
Peptide
MOTS-c
Outcome
IncreasePlasma MOTS-c in mice fed a hepatic lipid-accumulation diet
Study
mousen: not reported in source
Male C57Bl/6j mice fed a diet that induces hepatic lipid accumulation and damage
Outcome group
Liver fat and liver function · Liver
Source sentences
Summary
plasma MOTS-c and SHLP2 were higher in participants with elevated liver damage markers and in male C57Bl/6j mice fed a diet that induces hepatic lipid accumulation and damage
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3441951009

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

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