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Study · Measured the body's own peptide · 2021

7 results

Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors.

Dieli-Conwright CM, Sami N, Norris MK, Wan J, Kumagai H, Kim SJ, Cohen P

Scientific reports19 Aug 2021Cited by 31 (Europe PMC)

PMID34413391 (opens in a new tab)PMCIDPMC8376922 (opens in a new tab)DOI10.1038/s41598-021-96419-z (opens in a new tab)PepBankPUB-34413391
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Summary

MOTS-c is a mitochondrial derived peptide with exercise mimetic activity that elicits beneficial effects on metabolism and exercise capacity. Furthermore, MOTS-c effects in humans are affected by race, potentially via ethnic-specific mtDNA variations. Women treated for breast cancer are at an increased risk for cardiovascular disease, diabetes and obesity, due to side effects of cancer-treatments. We conducted a secondary analysis of the effects of a 16-week aerobic and resistance exercise intervention on MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors (BCS). BCS (Stage I-III) were randomized to exercise or standard care. The intervention promoted aerobic and resistance exercise for 16 weeks. MOTS-c was analyzed in fasting plasma using an in-house ELISA. Within and between group differences were assessed by paired t-test and repeated measures ANOVA. Pearson's correlation was computed to assess the association between MOTS-c and metabolic biomarkers at baseline and post-exercise. Twenty-five Hispanic-BCS and 24 non-Hispanic White BCS were included. Hispanic BCS were younger, of greater adiposity, had higher stage cancers, and had worse metabolic profiles at baseline compared to non-Hispanic White BCS (p < 0.001). Post-exercise, MOTS-c levels significantly increased when compared to baseline and the usual care group among non-Hispanic White BCS (p < 0.01) but not among Hispanic breast cancer survivors (p > 0.01). Post-exercise levels of MOTS-c among non-Hispanic White BCS were significantly associated with reductions in fat mass, body weight, HOMA-IR, CRP, and an increase in lean mass (p < 0.01). A 16-week aerobic and resistance intervention increased MOTS-c levels among non-Hispanic White BCS. Trial registration: This trial is registered on ClinicalTrials.gov: NCT01140282 as of June 9, 2010. https://clinicaltrials.gov/ct2/show/NCT01140282 .
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study7

No result from this study comes from a test of the peptide.

Natural levels measured7

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelRandomized controlled trialOther

    In Hispanic breast cancer survivors, the exercise intervention did not significantly change plasma MOTS‑c levels.

    In plain wordsIn Hispanic breast cancer survivors, 16 weeks of exercise did not clearly change the body's own MOTS‑c levels.

    Peptide
    MOTS-c
    Outcome
    No significant changePlasma MOTS-c after exercise in Hispanic breast cancer survivors
    Study

    n = 25

    Comparator
    Usual care group and baseline
    Outcome group
    Mitochondrial function · Whole body

    Source sentences

    Summary
    but not among Hispanic breast cancer survivors (p > 0.01).
    3 context sentences
    Summary · context
    Twenty-five Hispanic-BCS and 24 non-Hispanic White BCS were included.
    Summary · context
    We conducted a secondary analysis of the effects of a 16-week aerobic and resistance exercise intervention on MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors (BCS).
    Summary · context
    BCS (Stage I-III) were randomized to exercise or standard care.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelRandomized controlled trialOther

    In non-Hispanic White breast cancer survivors, a 16-week exercise intervention increased plasma MOTS‑c levels compared with baseline and usual care.

    In plain wordsIn non-Hispanic White breast cancer survivors, 16 weeks of exercise raised the body's own MOTS‑c levels compared with usual care.

    Peptide
    MOTS-c
    Outcome
    IncreasePlasma MOTS-c after exercise in non-Hispanic White breast cancer survivors
    Study

    n = 24

    Comparator
    Usual care group and baseline
    Outcome group
    Mitochondrial function · Whole body

    Source sentences

    Summary
    Post-exercise, MOTS-c levels significantly increased when compared to baseline and the usual care group among non-Hispanic White BCS (p  0.01).
    3 context sentences
    Summary · context
    A 16-week aerobic and resistance intervention increased MOTS-c levels among non-Hispanic White BCS.
    Summary · context
    We conducted a secondary analysis of the effects of a 16-week aerobic and resistance exercise intervention on MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors (BCS).
    Summary · context
    BCS (Stage I-III) were randomized to exercise or standard care.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelRandomized controlled trialOther

    In non-Hispanic White breast cancer survivors, post-exercise MOTS‑c levels were significantly associated with reductions in fat mass.

    In plain wordsIn non-Hispanic White breast cancer survivors, natural MOTS‑c levels after exercise were linked to reductions in fat mass.

    Peptide
    MOTS-c
    Outcome
    Not applicableAssociation of post-exercise MOTS-c with fat mass reduction
    Study

    n = 24

    Outcome group
    Mitochondrial function · Whole body

    Source sentences

    Summary
    Post-exercise levels of MOTS-c among non-Hispanic White BCS were significantly associated with reductions in fat mass, body weight, HOMA-IR, CRP, and an increase in lean mass (p < 0.01).
    2 context sentences
    Summary · context
    We conducted a secondary analysis of the effects of a 16-week aerobic and resistance exercise intervention on MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors (BCS).
    Summary · context
    BCS (Stage I-III) were randomized to exercise or standard care.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelRandomized controlled trialOther

    In non-Hispanic White breast cancer survivors, post-exercise MOTS‑c levels were significantly associated with reductions in body weight.

    In plain wordsIn non-Hispanic White breast cancer survivors, natural MOTS‑c levels after exercise were linked to reductions in body weight.

    Peptide
    MOTS-c
    Outcome
    Not applicableAssociation of post-exercise MOTS-c with body weight reduction
    Study

    n = 24

    Outcome group
    Mitochondrial function · Whole body

    Source sentences

    Summary
    Post-exercise levels of MOTS-c among non-Hispanic White BCS were significantly associated with reductions in fat mass, body weight, HOMA-IR, CRP, and an increase in lean mass (p < 0.01).
    2 context sentences
    Summary · context
    We conducted a secondary analysis of the effects of a 16-week aerobic and resistance exercise intervention on MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors (BCS).
    Summary · context
    BCS (Stage I-III) were randomized to exercise or standard care.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

  5. 05HumanEndogenous levelRandomized controlled trialOther

    In non-Hispanic White breast cancer survivors, post-exercise MOTS‑c levels were significantly associated with reductions in HOMA-IR.

    In plain wordsIn non-Hispanic White breast cancer survivors, natural MOTS‑c levels after exercise were linked to reductions in insulin resistance (HOMA-IR).

    Peptide
    MOTS-c
    Outcome
    Not applicableAssociation of post-exercise MOTS-c with HOMA-IR reduction
    Study

    n = 24

    Outcome group
    Mitochondrial function · Whole body

    Source sentences

    Summary
    Post-exercise levels of MOTS-c among non-Hispanic White BCS were significantly associated with reductions in fat mass, body weight, HOMA-IR, CRP, and an increase in lean mass (p < 0.01).
    2 context sentences
    Summary · context
    We conducted a secondary analysis of the effects of a 16-week aerobic and resistance exercise intervention on MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors (BCS).
    Summary · context
    BCS (Stage I-III) were randomized to exercise or standard care.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

  6. 06HumanEndogenous levelRandomized controlled trialOther

    In non-Hispanic White breast cancer survivors, post-exercise MOTS‑c levels were significantly associated with reductions in CRP.

    In plain wordsIn non-Hispanic White breast cancer survivors, natural MOTS‑c levels after exercise were linked to reductions in the inflammation marker CRP.

    Peptide
    MOTS-c
    Outcome
    Not applicableAssociation of post-exercise MOTS-c with CRP reduction
    Study

    n = 24

    Outcome group
    Mitochondrial function · Whole body

    Source sentences

    Summary
    Post-exercise levels of MOTS-c among non-Hispanic White BCS were significantly associated with reductions in fat mass, body weight, HOMA-IR, CRP, and an increase in lean mass (p < 0.01).
    2 context sentences
    Summary · context
    We conducted a secondary analysis of the effects of a 16-week aerobic and resistance exercise intervention on MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors (BCS).
    Summary · context
    BCS (Stage I-III) were randomized to exercise or standard care.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

  7. 07HumanEndogenous levelRandomized controlled trialOther

    In non-Hispanic White breast cancer survivors, post-exercise MOTS‑c levels were significantly associated with an increase in lean mass.

    In plain wordsIn non-Hispanic White breast cancer survivors, natural MOTS‑c levels after exercise were linked to an increase in lean mass.

    Peptide
    MOTS-c
    Outcome
    Not applicableAssociation of post-exercise MOTS-c with lean mass increase
    Study

    n = 24

    Outcome group
    Mitochondrial function · Whole body

    Source sentences

    Summary
    Post-exercise levels of MOTS-c among non-Hispanic White BCS were significantly associated with reductions in fat mass, body weight, HOMA-IR, CRP, and an increase in lean mass (p < 0.01).
    2 context sentences
    Summary · context
    We conducted a secondary analysis of the effects of a 16-week aerobic and resistance exercise intervention on MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors (BCS).
    Summary · context
    BCS (Stage I-III) were randomized to exercise or standard care.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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