In goldfish, intracerebroventricular melanotan II at 50 pmol/g body weight mimicked the action of alpha-MSH, which prolonged the time spent in the edge area of the tank.
In plain wordsIn goldfish, melanotan II injected into the brain had a similar effect to alpha-MSH, which made fish stay longer at the tank edge.
- Peptide
- Melanotan II
- Outcome
- IncreaseTime spent in the edge area of the tank (thigmotaxis)
- Study
goldfishn: not reported in source
Carassius auratus, edge-preference test- Outcome group
- Anxiety and mood · Mental health and mood
- Studied dose
- 50 pmol/g body weight · intracerebroventricularAs given in this study (goldfish).
Source sentences
The action of α-MSH mimicked those of FG-7142 (a central-type benzodiazepine receptor (CBR) inverse agonist with an anxiogenic effect) at 10 pmol g-1 BW and melanotan II (a melanocortin 4 receptor (MC4R) agonist) at 50 pmol g-1 BW
1 context sentence(design, population, supporting numbers)
When α-MSH was administered ICV at 1 and 10 pmol g-1 body weight (BW), the time spent in the edge area of a tank was prolonged at 10 pmol g-1 BW.