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Study · Measured the body's own peptide · 2021

2 results

Functional Antibodies and Innate Immune Responses to WRSS1, a Live Oral Shigella sonnei Vaccine Candidate, in Bangladeshi Adults and Children.

Sarker P, Mily A, Ara A, Haque F, Maier N, Wierzba TF, Walker RI, Venkatesan MM, Raqib R

The Journal of infectious diseases1 Dec 2021Cited by 15 (Europe PMC)

PMID34374425 (opens in a new tab)PMCIDPMC8687094 (opens in a new tab)DOI10.1093/infdis/jiab395 (opens in a new tab)PepBankPUB-34374425
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Summary

BackgroundWe demonstrated in a randomized placebo-controlled trial that WRSS1, a live oral Shigella sonnei vaccine candidate, is safe in Bangladeshi adults and children, and elicits antigen-specific antibodies. Here, we describe functional antibody and innate immune responses to WRSS1.MethodsAdults (18-39 years) and children (5-9 years) received 3 doses of 3 × 105 or 3 × 106 colony forming units (CFU) of WRSS1 or placebo, 4 weeks apart; children additionally received 3 × 104 CFU. Blood and stool were collected at baseline and 7 days after each dose. Functional antibodies were measured using serum bactericidal antibody (SBA) assay. Cytokine/chemokine concentrations were measured in lymphocyte cultures. Host defense peptides LL-37, HBD-1, and HD-5 were analyzed in plasma and stool.ResultsChildren showed increased SBA titers over baseline after the third dose of 3 × 106 CFU (P = .048). Significant increases of Th-17 and proinflammatory cytokines (TNF-α, G-CSF, MIP-1β), and reduction of anti-inflammatory and Th2 cytokines (IL-10, IL-13, GM-CSF) were observed in children. Plasma HBD-1 and LL-37 decreased in children after vaccination but were increased/unchanged in adults.ConclusionsFunctional antibodies and Th1/Th17 cytokine responses in children may serve as important indicators of immunogenicity and protective potential of WRSS1. Clinical Trials Registration: NCT01813071.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelRandomized controlled trialOther

    In Bangladeshi children, plasma LL‑37 decreased after vaccination with the live oral Shigella sonnei vaccine candidate WRSS1.

    In plain wordsIn children, the body's own LL‑37 levels in blood were lower after vaccination with the Shigella vaccine candidate.

    Peptide
    LL-37
    Outcome
    DecreasePlasma LL-37 after WRSS1 vaccination in children
    Study

    n: not reported in source

    Comparator
    Baseline
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Plasma HBD-1 and LL-37 decreased in children after vaccination
    2 context sentences
    Summary · context
    Adults (18-39 years) and children (5-9 years) received 3 doses of 3 × 105 or 3 × 106 colony forming units (CFU) of WRSS1 or placebo, 4 weeks apart; children additionally received 3 × 104 CFU.
    Summary · context
    Host defense peptides LL-37, HBD-1, and HD-5 were analyzed in plasma and stool.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelRandomized controlled trialOther

    In Bangladeshi adults, plasma LL‑37 was increased or unchanged after vaccination with the live oral Shigella sonnei vaccine candidate WRSS1.

    In plain wordsIn adults, the Shigella vaccine candidate left the body's own LL‑37 in blood higher or unchanged.

    Peptide
    LL-37
    Outcome
    MixedPlasma LL-37 after WRSS1 vaccination in adults
    Study

    n: not reported in source

    Comparator
    Baseline
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    but were increased/unchanged in adults.
    2 context sentences
    Summary · context
    Adults (18-39 years) and children (5-9 years) received 3 doses of 3 × 105 or 3 × 106 colony forming units (CFU) of WRSS1 or placebo, 4 weeks apart; children additionally received 3 × 104 CFU.
    Summary · context
    Host defense peptides LL-37, HBD-1, and HD-5 were analyzed in plasma and stool.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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