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Study · Not a test of the peptide alone · 2021

3 results

Combinations of peptides synergistically activate the regenerative capacity of skin cells in vitro.

Flagler MJ, Tamura M, Laughlin T, Hartman S, Ashe J, Adams R, Kozak K, Cresswell K, Mullins L, Jarrold BB, Isfort RJ, Sherrill JD

International journal of cosmetic science25 Aug 2021Cited by 8 (Europe PMC)

PMID34272744 (opens in a new tab)PMCIDPMC9291327 (opens in a new tab)DOI10.1111/ics.12725 (opens in a new tab)PepBankPUB-34272744
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Matrixyl (palmitoyl pentapeptide-4).

  1. 01LabNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneIn vitro (cells)Mechanism

    In skin cells, pooled peptide combinations showed synergistic gene-expression changes compared with individual peptides.

    In plain wordsIn cells, pooled peptide combinations changed gene expression synergistically compared with individual peptides.

    Peptide
    Matrixyl (palmitoyl pentapeptide-4)
    Outcome
    MixedSynergistic gene expression
    Study

    n: not reported in source

    Comparator
    Individual peptide controls
    Outcome group
    Receptor activity and mechanism · Skin and wound

    Source sentences

    Summary
    Microarray analysis of skin cells treated with peptide combinations revealed synergistic changes in gene expression compared with individual peptide controls.
    1 context sentence
    Summary · context
    Microarray profiling was used to characterize the biological responses of peptide combinations (+/- Nam) relative to the individual components in epidermal keratinocyte and dermal fibroblast cell lines.

    In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).

  2. 02LabNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneIn vitro (cells)Mechanism

    In keratinocytes, the Ac-PPYL-Pal-KTTKS-niacinamide combination synergistically regulated NRF2/ARE downstream targets, with support from a cellular reporter assay.

    In plain wordsIn cells, the Ac-PPYL-Pal-KTTKS-niacinamide mixture synergistically regulated NRF2/ARE target genes, with support from a reporter test.

    Peptide
    Matrixyl (palmitoyl pentapeptide-4)
    Outcome
    MixedNRF2/ARE downstream target regulation
    Study

    n: not reported in source

    Keratinocytes
    Outcome group
    Receptor activity and mechanism · Skin and wound

    Source sentences

    Summary
    Additional analysis revealed direct downstream transcriptional targets of NRF2/ARE exhibiting synergistic regulation by this combination of materials, which was corroborated by a cellular reporter assay.
    2 context sentences
    Summary · context
    Bioinformatic analysis of synergy genes in keratinocytes revealed the activation of NRF2-mediated oxidative stress responses by a combination of Ac-PPYL, Pal-KTTKS and Nam.
    Summary · context
    Microarray profiling was used to characterize the biological responses of peptide combinations (+/- Nam) relative to the individual components in epidermal keratinocyte and dermal fibroblast cell lines.

    In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).

  3. 03Computer modelNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneIn silicoMechanism

    Bioinformatic analysis of keratinocyte synergy genes indicated NRF2-mediated oxidative stress response activation with Ac-PPYL, Pal-KTTKS and niacinamide.

    In plain wordsIn computer analyses of keratinocyte genes, the Ac-PPYL-Pal-KTTKS-niacinamide mixture showed activation of NRF2-related stress responses.

    Peptide
    Matrixyl (palmitoyl pentapeptide-4)
    Outcome
    IncreaseNRF2-mediated oxidative stress response
    Study

    n: not reported in source

    Keratinocytes
    Outcome group
    Receptor activity and mechanism · Skin and wound

    Source sentences

    Summary
    Bioinformatic analysis of synergy genes in keratinocytes revealed the activation of NRF2-mediated oxidative stress responses by a combination of Ac-PPYL, Pal-KTTKS and Nam.
    1 context sentence
    Summary · context
    Microarray profiling was used to characterize the biological responses of peptide combinations (+/- Nam) relative to the individual components in epidermal keratinocyte and dermal fibroblast cell lines.

    In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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