Effect of a neurostimulator on postnatal neurogenesis in rodent olfactory bulbs.

Varentsov VE, Rumyanceva TA, Verzilina AD, Pshenisnov KK, Rudenko EE, Nikolenko VN, Shevchuk IV, Sinelnikov MY

Neuropeptides9 Jul 2021Cited by 1 (Europe PMC)

PMID34271452DOI10.1016/j.npep.2021.102181PepBankPUB-34271452

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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In young rats, TKPRPGP given from birth to 14 days preserved nestin expression in the olfactory bulb, preventing its decrease; expression lasted up to 35 days of observation.
In plain wordsIn young rats, the peptide kept the neural progenitor marker nestin from falling in the smell centre of the brain.
Peptide
Selank
Outcome
IncreaseNestin expression in olfactory bulb during administration
Study
ratn: not reported in source
White Wistar rats, olfactory bulb
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · from birth to 14 daysAs given in this study (rat).
Measurements
Duration of nestin expression
≤ 35 days
observation after early administration
Source sentences
Summary
stimulation from birth to 14 days preserves the level of nestin expression, preventing its decrease.
2 context sentences(design, population, supporting numbers)
Summary · context
prolongs the expression of nestin and doublecortin in the olfactory bulbs of rats up to 35 days and up to 74 days of observation, respectively.
Summary · context
The aim of the study was to reveal the effect of neurostimulation with the TKPRPGP neuropeptide on the expression intensity of Doublecortin and Nestin in the olfactory bulb of white Wistar rats using immunohistochemical and computer analysis methods.
Report a problemFND-3427145201
02AnimalAnimal study (in vivo)Efficacy outcome
In rats, nestin expression in the olfactory bulb fell sharply when administration of TKPRPGP stopped, and after three weeks it was no longer present.
In plain wordsIn rats, the nestin marker dropped sharply after the peptide stopped, and it was gone after three weeks.
Peptide
Selank
Outcome
DecreaseNestin expression after stopping administration
Study
ratn: not reported in source
White Wistar rats, olfactory bulb
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
When the administration of the neuropeptide is stopped, the expression of nestin decreases sharply, starting from the central zones of the bulb, and after three weeks it is no longer present.
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of the study was to reveal the effect of neurostimulation with the TKPRPGP neuropeptide on the expression intensity of Doublecortin and Nestin in the olfactory bulb of white Wistar rats using immunohistochemical and computer analysis methods.
Report a problemFND-3427145202
03AnimalAnimal study (in vivo)Efficacy outcome
In rats, TKPRPGP administration increased the density of doublecortin-positive structures in the olfactory bulb; expression lasted up to 74 days of observation.
In plain wordsIn rats, the peptide raised the level of the young-neuron marker doublecortin in the smell centre of the brain.
Peptide
Selank
Outcome
IncreaseDoublecortin-positive structure density in olfactory bulb
Study
ratn: not reported in source
White Wistar rats, olfactory bulb
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Measurements
Duration of doublecortin expression
≤ 74 days
observation after early administration
Source sentences
Summary
The dynamics of doublecortin positive structure density reflects an increase upon neuropeptide administration.
2 context sentences(design, population, supporting numbers)
Summary · context
prolongs the expression of nestin and doublecortin in the olfactory bulbs of rats up to 35 days and up to 74 days of observation, respectively.
Summary · context
The aim of the study was to reveal the effect of neurostimulation with the TKPRPGP neuropeptide on the expression intensity of Doublecortin and Nestin in the olfactory bulb of white Wistar rats using immunohistochemical and computer analysis methods.
Report a problemFND-3427145203
04AnimalAnimal study (in vivo)Efficacy outcome
In rats, each course of TKPRPGP raised the density of the doublecortin marker, but the effect and its duration decreased with age.
In plain wordsIn rats, each course of the peptide raised the doublecortin marker, but the effect got smaller and shorter with age.
Peptide
Selank
Outcome
MixedDoublecortin density response to each course by age
Study
ratn: not reported in source
White Wistar rats, olfactory bulb
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Each course of neuropeptide administration caused an increase in the density of the marker, but the degree of effectiveness decreased with age, and the duration of the effect decreased.
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of the study was to reveal the effect of neurostimulation with the TKPRPGP neuropeptide on the expression intensity of Doublecortin and Nestin in the olfactory bulb of white Wistar rats using immunohistochemical and computer analysis methods.
Report a problemFND-3427145204
05AnimalAnimal study (in vivo)Efficacy outcome
In adult rats, TKPRPGP administration did not lead to re-expression of nestin and doublecortin.
In plain wordsIn adult rats, giving the peptide did not bring back the nestin and doublecortin markers.
Peptide
Selank
Outcome
No significant changeNestin and doublecortin expression after administration in adulthood
Study
ratn: not reported in source
White Wistar rats, olfactory bulb
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
The administration of the neuropeptide in adulthood does not lead to re-expression of these markers.
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of the study was to reveal the effect of neurostimulation with the TKPRPGP neuropeptide on the expression intensity of Doublecortin and Nestin in the olfactory bulb of white Wistar rats using immunohistochemical and computer analysis methods.
Report a problemFND-3427145205

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 19:08 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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