Noopept Attenuates Diabetes-Mediated Neuropathic Pain and Oxidative Hippocampal Neurotoxicity via Inhibition of TRPV1 Channel in Rats.

Düzova H, Nazıroğlu M, Çiğ B, Gürbüz P, Akatlı AN

Molecular neurobiology9 Jul 2021Cited by 28 (Europe PMC)

PMID34241806DOI10.1007/s12035-021-02478-8PepBankPUB-34241806

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study19

19 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, noopept reduced STZ-mediated neuropathic pain assessed with Von Frey and hot plate tests.
In plain wordsIn diabetic rats, noopept reduced neuropathic pain compared with untreated diabetes.
Peptide
Noopept (omberacetam)
Outcome
DecreaseNeuropathic pain
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
STZ-induced diabetes without NP
Outcome group
Pain · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
A decrease on the STZ-mediated increase of neuropathic pain (via the analyses of Von Frey and hot plate) and blood glucose level was observed by the treatment of NP.
1 context sentence(design, population, supporting numbers)
Summary · context
Thirty-six rats were equally divided into control, NP, DM (streptozotocin, STZ), and STZ + NP groups.
Report a problemFND-3424180601
02AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, noopept reduced the STZ-mediated increase in blood glucose.
In plain wordsIn diabetic rats, noopept reduced blood glucose compared with untreated diabetes.
Peptide
Noopept (omberacetam)
Outcome
DecreaseBlood glucose
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
STZ-induced diabetes without NP
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
A decrease on the STZ-mediated increase of neuropathic pain (via the analyses of Von Frey and hot plate) and blood glucose level was observed by the treatment of NP.
1 context sentence(design, population, supporting numbers)
Summary · context
Thirty-six rats were equally divided into control, NP, DM (streptozotocin, STZ), and STZ + NP groups.
Report a problemFND-3424180602
03AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, noopept reduced STZ-induced apoptosis in dorsal root ganglia and hippocampus.
In plain wordsIn diabetic rats, noopept reduced nerve tissue cell death compared with untreated diabetes.
Peptide
Noopept (omberacetam)
Outcome
DecreaseApoptosis in DRGs and hippocampus
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
STZ-induced diabetes without NP
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
A protective role of NP via downregulation of TRPV1 activity
2 context sentences(design, population, supporting numbers)
Summary · context
on the STZ-induced increase of apoptosis, mitochondrial fROS, lipid peroxidation, caspase -3 (CASP-3), caspase -9 (CASP-9), TRPV1 current density, glutathione (GSH), cytosolic free Zn²⁺, and Ca²⁺ concentrations in the DRGs and HIPPO was also observed.
Summary · context
Thirty-six rats were equally divided into control, NP, DM (streptozotocin, STZ), and STZ + NP groups.
Report a problemFND-3424180603
04AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, noopept reduced STZ-induced mitochondrial free oxygen radicals in dorsal root ganglia and hippocampus.
In plain wordsIn diabetic rats, noopept reduced mitochondrial free oxygen radicals in nerve tissues compared with untreated diabetes.
Peptide
Noopept (omberacetam)
Outcome
DecreaseMitochondrial free oxygen radicals
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
STZ-induced diabetes without NP
Outcome group
Mitochondrial function · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
A protective role of NP via downregulation of TRPV1 activity
2 context sentences(design, population, supporting numbers)
Summary · context
on the STZ-induced increase of apoptosis, mitochondrial fROS, lipid peroxidation, caspase -3 (CASP-3), caspase -9 (CASP-9), TRPV1 current density, glutathione (GSH), cytosolic free Zn²⁺, and Ca²⁺ concentrations in the DRGs and HIPPO was also observed.
Summary · context
Thirty-six rats were equally divided into control, NP, DM (streptozotocin, STZ), and STZ + NP groups.
Report a problemFND-3424180604
05AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, noopept reduced STZ-induced lipid peroxidation in dorsal root ganglia and hippocampus.
In plain wordsIn diabetic rats, noopept reduced nerve tissue lipid peroxidation compared with untreated diabetes.
Peptide
Noopept (omberacetam)
Outcome
DecreaseLipid peroxidation
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
STZ-induced diabetes without NP
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
A protective role of NP via downregulation of TRPV1 activity
2 context sentences(design, population, supporting numbers)
Summary · context
on the STZ-induced increase of apoptosis, mitochondrial fROS, lipid peroxidation, caspase -3 (CASP-3), caspase -9 (CASP-9), TRPV1 current density, glutathione (GSH), cytosolic free Zn²⁺, and Ca²⁺ concentrations in the DRGs and HIPPO was also observed.
Summary · context
Thirty-six rats were equally divided into control, NP, DM (streptozotocin, STZ), and STZ + NP groups.
Report a problemFND-3424180605
06AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, noopept reduced the STZ-induced increase in caspase-3 in dorsal root ganglia and hippocampus.
In plain wordsIn diabetic rats, noopept reduced nerve tissue caspase-3 compared with untreated diabetes.
Peptide
Noopept (omberacetam)
Outcome
DecreaseCaspase-3
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
STZ-induced diabetes without NP
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
A protective role of NP via downregulation of TRPV1 activity
2 context sentences(design, population, supporting numbers)
Summary · context
on the STZ-induced increase of apoptosis, mitochondrial fROS, lipid peroxidation, caspase -3 (CASP-3), caspase -9 (CASP-9), TRPV1 current density, glutathione (GSH), cytosolic free Zn²⁺, and Ca²⁺ concentrations in the DRGs and HIPPO was also observed.
Summary · context
Thirty-six rats were equally divided into control, NP, DM (streptozotocin, STZ), and STZ + NP groups.
Report a problemFND-3424180606
07AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, noopept reduced the STZ-induced increase in caspase-9 in dorsal root ganglia and hippocampus.
In plain wordsIn diabetic rats, noopept reduced nerve tissue caspase-9 compared with untreated diabetes.
Peptide
Noopept (omberacetam)
Outcome
DecreaseCaspase-9
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
STZ-induced diabetes without NP
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
A protective role of NP via downregulation of TRPV1 activity
2 context sentences(design, population, supporting numbers)
Summary · context
on the STZ-induced increase of apoptosis, mitochondrial fROS, lipid peroxidation, caspase -3 (CASP-3), caspase -9 (CASP-9), TRPV1 current density, glutathione (GSH), cytosolic free Zn²⁺, and Ca²⁺ concentrations in the DRGs and HIPPO was also observed.
Summary · context
Thirty-six rats were equally divided into control, NP, DM (streptozotocin, STZ), and STZ + NP groups.
Report a problemFND-3424180607
08AnimalAnimal study (in vivo)Mechanism
In diabetic rats, noopept reduced STZ-induced TRPV1 current density in dorsal root ganglia and hippocampus.
In plain wordsIn diabetic rats, noopept reduced nerve tissue TRPV1 current density compared with untreated diabetes.
Peptide
Noopept (omberacetam)
Outcome
DecreaseTRPV1 current density
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
STZ-induced diabetes without NP
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
A protective role of NP via downregulation of TRPV1 activity
2 context sentences(design, population, supporting numbers)
Summary · context
on the STZ-induced increase of apoptosis, mitochondrial fROS, lipid peroxidation, caspase -3 (CASP-3), caspase -9 (CASP-9), TRPV1 current density, glutathione (GSH), cytosolic free Zn²⁺, and Ca²⁺ concentrations in the DRGs and HIPPO was also observed.
Summary · context
Thirty-six rats were equally divided into control, NP, DM (streptozotocin, STZ), and STZ + NP groups.
Report a problemFND-3424180608
09AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, noopept reduced the reported STZ-induced increase in GSH in dorsal root ganglia and hippocampus.
In plain wordsIn diabetic rats, noopept reduced the reported nerve tissue GSH increase compared with untreated diabetes.
Peptide
Noopept (omberacetam)
Outcome
DecreaseGSH in DRGs and hippocampus
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
STZ-induced diabetes without NP
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
A protective role of NP via downregulation of TRPV1 activity
2 context sentences(design, population, supporting numbers)
Summary · context
on the STZ-induced increase of apoptosis, mitochondrial fROS, lipid peroxidation, caspase -3 (CASP-3), caspase -9 (CASP-9), TRPV1 current density, glutathione (GSH), cytosolic free Zn²⁺, and Ca²⁺ concentrations in the DRGs and HIPPO was also observed.
Summary · context
Thirty-six rats were equally divided into control, NP, DM (streptozotocin, STZ), and STZ + NP groups.
Report a problemFND-3424180609
10AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, noopept reduced STZ-induced cytosolic free zinc concentrations in dorsal root ganglia and hippocampus.
In plain wordsIn diabetic rats, noopept reduced nerve tissue free zinc compared with untreated diabetes.
Peptide
Noopept (omberacetam)
Outcome
DecreaseCytosolic free zinc
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
STZ-induced diabetes without NP
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
A protective role of NP via downregulation of TRPV1 activity on the STZ-induced increase of apoptosis, mitochondrial fROS, lipid peroxidation, caspase -3 (CASP-3), caspase -9 (CASP-9), TRPV1 current density, glutathione (GSH), cytosolic free Zn²⁺, and Ca²⁺ concentrations in the…
1 context sentence(design, population, supporting numbers)
Summary · context
Thirty-six rats were equally divided into control, NP, DM (streptozotocin, STZ), and STZ + NP groups.
Report a problemFND-3424180610
11AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, noopept reduced STZ-induced cytosolic calcium concentrations in dorsal root ganglia and hippocampus.
In plain wordsIn diabetic rats, noopept reduced nerve tissue calcium compared with untreated diabetes.
Peptide
Noopept (omberacetam)
Outcome
DecreaseCytosolic calcium
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
STZ-induced diabetes without NP
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
A protective role of NP via downregulation of TRPV1 activity on the STZ-induced increase of apoptosis, mitochondrial fROS, lipid peroxidation, caspase -3 (CASP-3), caspase -9 (CASP-9), TRPV1 current density, glutathione (GSH), cytosolic free Zn²⁺, and Ca²⁺ concentrations in the…
1 context sentence(design, population, supporting numbers)
Summary · context
Thirty-six rats were equally divided into control, NP, DM (streptozotocin, STZ), and STZ + NP groups.
Report a problemFND-3424180611
12AnimalAnimal study (in vivo)Mechanism
In diabetic rats, noopept downregulated TRPV1 activity in dorsal root ganglia and hippocampus.
In plain wordsIn diabetic rats, noopept reduced nerve tissue TRPV1 activity compared with untreated diabetes.
Peptide
Noopept (omberacetam)
Outcome
DecreaseTRPV1 activity
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
STZ-induced diabetes without NP
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
A protective role of NP via downregulation of TRPV1 activity
1 context sentence(design, population, supporting numbers)
Summary · context
Thirty-six rats were equally divided into control, NP, DM (streptozotocin, STZ), and STZ + NP groups.
Report a problemFND-3424180612
13AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, noopept attenuated the STZ-mediated decrease in glutathione peroxidase across the listed tissues and fluids.
In plain wordsIn diabetic rats, noopept reduced the loss of glutathione peroxidase compared with untreated diabetes.
Peptide
Noopept (omberacetam)
Outcome
IncreaseGlutathione peroxidase
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
STZ-induced diabetes without NP
Outcome group
Neuroprotection · Whole body
Studied dose
Dose not stated
Source sentences
Summary
The STZ-mediated decrease of glutathione peroxidase, GSH, vitamin E, and β-carotene concentrations in the brain cortex, erythrocyte, liver, kidney, and plasma was also attenuated by the treatment of NP.
1 context sentence(design, population, supporting numbers)
Summary · context
Thirty-six rats were equally divided into control, NP, DM (streptozotocin, STZ), and STZ + NP groups.
Report a problemFND-3424180613
14AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, noopept attenuated the STZ-mediated decrease in GSH in brain cortex, erythrocyte, liver, kidney, and plasma.
In plain wordsIn diabetic rats, noopept reduced GSH loss in the listed tissues and fluids compared with untreated diabetes.
Peptide
Noopept (omberacetam)
Outcome
IncreaseGSH in cortex and peripheral tissues
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
STZ-induced diabetes without NP
Outcome group
Neuroprotection · Whole body
Studied dose
Dose not stated
Source sentences
Summary
The STZ-mediated decrease of glutathione peroxidase, GSH, vitamin E, and β-carotene concentrations in the brain cortex, erythrocyte, liver, kidney, and plasma was also attenuated by the treatment of NP.
1 context sentence(design, population, supporting numbers)
Summary · context
Thirty-six rats were equally divided into control, NP, DM (streptozotocin, STZ), and STZ + NP groups.
Report a problemFND-3424180614
15AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, noopept attenuated the STZ-mediated decrease in vitamin E concentrations across the listed tissues and fluids.
In plain wordsIn diabetic rats, noopept reduced vitamin E loss compared with untreated diabetes.
Peptide
Noopept (omberacetam)
Outcome
IncreaseVitamin E
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
STZ-induced diabetes without NP
Outcome group
Neuroprotection · Whole body
Studied dose
Dose not stated
Source sentences
Summary
The STZ-mediated decrease of glutathione peroxidase, GSH, vitamin E, and β-carotene concentrations in the brain cortex, erythrocyte, liver, kidney, and plasma was also attenuated by the treatment of NP.
1 context sentence(design, population, supporting numbers)
Summary · context
Thirty-six rats were equally divided into control, NP, DM (streptozotocin, STZ), and STZ + NP groups.
Report a problemFND-3424180615
16AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, noopept attenuated the STZ-mediated decrease in β-carotene concentrations across the listed tissues and fluids.
In plain wordsIn diabetic rats, noopept reduced β-carotene loss compared with untreated diabetes.
Peptide
Noopept (omberacetam)
Outcome
Increaseβ-carotene
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
STZ-induced diabetes without NP
Outcome group
Neuroprotection · Whole body
Studied dose
Dose not stated
Source sentences
Summary
The STZ-mediated decrease of glutathione peroxidase, GSH, vitamin E, and β-carotene concentrations in the brain cortex, erythrocyte, liver, kidney, and plasma was also attenuated by the treatment of NP.
1 context sentence(design, population, supporting numbers)
Summary · context
Thirty-six rats were equally divided into control, NP, DM (streptozotocin, STZ), and STZ + NP groups.
Report a problemFND-3424180616
17AnimalAnimal study (in vivo)Mechanism
In diabetic rats, noopept decreased STZ-mediated TRPV1 expression in dorsal root ganglia and hippocampus.
In plain wordsIn diabetic rats, noopept reduced nerve tissue TRPV1 expression compared with untreated diabetes.
Peptide
Noopept (omberacetam)
Outcome
DecreaseTRPV1 expression
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
STZ-induced diabetes without NP
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
The STZ-mediated increase of TRPV1, CASP-3, and CASP-9 expressions was decreased in the DRGs and HIPPO by the treatment of NP.
1 context sentence(design, population, supporting numbers)
Summary · context
Thirty-six rats were equally divided into control, NP, DM (streptozotocin, STZ), and STZ + NP groups.
Report a problemFND-3424180617
18AnimalAnimal study (in vivo)Mechanism
In diabetic rats, noopept decreased STZ-mediated CASP-3 expression in dorsal root ganglia and hippocampus.
In plain wordsIn diabetic rats, noopept reduced nerve tissue CASP-3 expression compared with untreated diabetes.
Peptide
Noopept (omberacetam)
Outcome
DecreaseCASP-3 expression
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
STZ-induced diabetes without NP
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
The STZ-mediated increase of TRPV1, CASP-3, and CASP-9 expressions was decreased in the DRGs and HIPPO by the treatment of NP.
1 context sentence(design, population, supporting numbers)
Summary · context
Thirty-six rats were equally divided into control, NP, DM (streptozotocin, STZ), and STZ + NP groups.
Report a problemFND-3424180618
19AnimalAnimal study (in vivo)Mechanism
In diabetic rats, noopept decreased STZ-mediated CASP-9 expression in dorsal root ganglia and hippocampus.
In plain wordsIn diabetic rats, noopept reduced nerve tissue CASP-9 expression compared with untreated diabetes.
Peptide
Noopept (omberacetam)
Outcome
DecreaseCASP-9 expression
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
STZ-induced diabetes without NP
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
The STZ-mediated increase of TRPV1, CASP-3, and CASP-9 expressions was decreased in the DRGs and HIPPO by the treatment of NP.
1 context sentence(design, population, supporting numbers)
Summary · context
Thirty-six rats were equally divided into control, NP, DM (streptozotocin, STZ), and STZ + NP groups.
Report a problemFND-3424180619

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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